Abstract: Methods and systems for replacement of advertisements received over an over-the-air radio broadcast signal with IP-delivered targeted advertisements are provided. The methods include a method for processing an audio broadcast signal in a broadcast radio receiver, wherein an ad insertion start sample count that indicates the start of an original advertisement content is received at the broadcast radio receiver. After synchronization of the transmitted and the received audio streams, a targeted advertisement content which replaces at least some of the original advertisement content is inserted in the audio stream starting with the sample associated with the ad insertion start sample count. Replacing original advertisement content with targeted advertisement content ends with a sample of the audio stream associated with an ad insertion stop sample count.