Patents by Inventor Michael Ratka

Michael Ratka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing recombinant trypsin
    Patent number: 7666629
    Abstract: The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to ?-trypsin and autolysis of ?-trypsin by ?-trypsin into ?-trypsin and from there into inactive peptides.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: February 23, 2010
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rainer Muller, Stephan Glaser, Frank Geipel, Johann-Peter Thalhofer, Bernhard Rexer, Claus Schneider, Michael Ratka, Stephanie Ronning, Hellmut Eckstein, Claudia Giessel
  • Method For Producing Recombinant Trypsin
    Publication number: 20080064084
    Abstract: The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to ?-trypsin and autolysis of ?-trypsin by ?-trypsin into ?-trypsin and from there into inactive peptides.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 13, 2008
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Rainer MULLER, Stephan GLASER, Frank GEIPEL, Johann-Peter THALHOFER, Bernhard REXER, Claus SCHNEIDER, Michael RATKA, Stephanie RONNING, Hellmut ECKSTEIN, Claudia GIESSEL
  • Method for producing recombinant trypsin
    Patent number: 7276605
    Abstract: The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to ?-trypsin and autolysis of ?-trypsin by ?-trypsin into ?-trypsin and from there into inactive peptides.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: October 2, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rainer Muller, Stephan Glaser, Frank Geipel, Johann-Peter Thalhofer, Bernhard Rexer, Claus Schneider, Michael Ratka, Stephanie Ronning, Hellmut Eckstein, Claudia Giessel
  • Method for producing recombinant trypsin
    Publication number: 20040203095
    Abstract: The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to &bgr;-trypsin and autolysis of &bgr;-trypsin by &agr;-trypsin into &egr;-trypsin and from there into inactive peptides.
    Type: Application
    Filed: April 12, 2004
    Publication date: October 14, 2004
    Inventors: Rainer Muller, Stephan Glaser, Frank Geipel, Johann-Peter Thalhofer, Bernhard Rexer, Claus Schneider, Michael Ratka, Stephanie Ronning, Hellmut Eckstein, Claudia Giessel