Abstract: An ATP non-competitive inhibitor of mitogen-activated protein kinase (MEK), inter alia, human MEK (MEK1 or MEK2) having the properties: (i) allosterically binds an inhibitor pocket formed at an interaction interface between human MEK (MEK1 or MEK2) and human Kinase Suppressor of Ras (KSR1 or KSR2 or BRAF) adjacent to ATP in a physiological complex between MEK and KSR (or BRAF), forming an inhibitor-inhibitor pocket complex; (ii) is an ATP non-competitive kinase inhibitor; (iii) a structure such that when bound to the inhibitor-inhibitor pocket complex, the complex comprises the structural elements: (a) at least one moiety of the inhibitor engaging A825 of KSR1, or P878 of KSR2; or R662 of BRAF (b) at least one moiety engaging R234 of MEK, wherein where R234 is within 5 ? from any atoms of KSR1 or KSR2 or BRAF is disclosed.

Abstract: The present invention relates to the compounds of formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with cancers associated with protein kinases, to their use as medicaments for use in the production of inhibition of mTor, pi3k reducing effects in warm-blooded animals such as humans.

Abstract: A gaze direction determining system and method is provided. A two-camera system may detect the face from a fixed, wide-angle camera, estimates a rough location for the eye region using an eye detector based on topographic features, and directs another active pan-tilt-zoom camera to focus in on this eye region. A eye gaze estimation approach employs point-of-regard (PoG) tracking on a large viewing screen. To allow for greater head pose freedom, a calibration approach is provided to find the 3D eyeball location, eyeball radius, and fovea position. Both the iris center and iris contour points are mapped to the eyeball sphere (creating a 3D iris disk) to get the optical axis; then the fovea rotated accordingly and the final, visual axis gaze direction computed.

Abstract: (Formula I), The present invention relates to the compounds of formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with cancers associated with protein kinases, to their use as medicaments for use in the production of inhibition of mTor, pi3k reducing effects in warm-blooded animals such as humans.

Abstract: A gaze direction determining system and method is provided. A two-camera system may detect the face from a fixed, wide-angle camera, estimates a rough location for the eye region using an eye detector based on topographic features, and directs another active pan-tilt-zoom camera to focus in on this eye region. A eye gaze estimation approach employs point-of-regard (PoG) tracking on a large viewing screen. To allow for greater head pose freedom, a calibration approach is provided to find the 3D eyeball location, eyeball radius, and fovea position. Both the iris center and iris contour points are mapped to the eyeball sphere (creating a 3D iris disk) to get the optical axis; then the fovea rotated accordingly and the final, visual axis gaze direction computed.

Abstract: A semiconductor package includes a substrate, an RF semiconductor die attached to a first side of the substrate, a capacitor attached to the first side of the substrate, and a first terminal on the first side of the substrate. The semiconductor package further includes copper or aluminum bonding wires or ribbons connecting the first terminal to an output of the RF semiconductor die, and gold bonding wires or ribbons connecting the capacitor to the output of the RF semiconductor die. The gold bonding wires or ribbons are designed to accommodate greater RF Joule heating during operation of the RF semiconductor die than the copper or aluminum bonding wires or ribbons. Corresponding methods of manufacturing are also described.

Abstract: A gaze direction determining system and method is provided. A two-camera system may detect the face from a fixed, wide-angle camera, estimates a rough location for the eye region using an eye detector based on topographic features, and directs another active pan-tilt-zoom camera to focus in on this eye region. A eye gaze estimation approach employs point-of-regard (PoG) tracking on a large viewing screen. To allow for greater head pose freedom, a calibration approach is provided to find the 3D eyeball location, eyeball radius, and fovea position. Both the iris center and iris contour points are mapped to the eyeball sphere (creating a 3D iris disk) to get the optical axis; then the fovea rotated accordingly and the final, visual axis gaze direction computed.

Abstract: A semiconductor package includes a substrate, an RF semiconductor die attached to a first side of the substrate, a capacitor attached to the first side of the substrate, and a first terminal on the first side of the substrate. The semiconductor package further includes copper or aluminum bonding wires or ribbons connecting the first terminal to an output of the RF semiconductor die, and gold bonding wires or ribbons connecting the capacitor to the output of the RF semiconductor die. The gold bonding wires or ribbons are designed to accommodate greater RF Joule heating during operation of the RF semiconductor die than the copper or aluminum bonding wires or ribbons. Corresponding methods of manufacturing are also described.

Abstract: A gaze direction determining system and method is provided. A two-camera system may detect the face from a fixed, wide-angle camera, estimates a rough location for the eye region using an eye detector based on topographic features, and directs another active pan-tilt-zoom camera to focus in on this eye region. A eye gaze estimation approach employs point-of-regard (PoG) tracking on a large viewing screen. To allow for greater head pose freedom, a calibration approach is provided to find the 3D eyeball location, eyeball radius, and fovea position. Both the iris center and iris contour points are mapped to the eyeball sphere (creating a 3D iris disk) to get the optical axis; then the fovea rotated accordingly and the final, visual axis gaze direction computed.

Abstract: A method for operating a gas turbine engine, including a first compressor, a second compressor, and a turbine, coupled together in serial flow arrangement. The method includes channeling compressed airflow discharged from the first compressor through an intercooler having a cooling medium flowing therethrough, operating the intercooler such that condensate is formed in the intercooler from the compressed airflow, and channeling the condensate to an inlet of the first or second compressor to facilitate reducing an operating temperature of the gas turbine engine.

Abstract: A method for operating a gas turbine engine, including a first compressor, a second compressor, a combustor and a turbine, coupled together in serial flow arrangement, and an intercooler coupled between the first compressor and the second compressor, the intercooler including a first heat exchanger and a second heat exchanger. The method includes channeling compressed airflow from the first compressor to the first heat exchanger, extracting energy from the compressed airflow using a first working fluid flowing through the first heat exchanger to facilitate reducing an operating temperature of the compressed airflow and to facilitate increasing an operating temperature of the first working fluid, and channeling the first working fluid to a process heat exchanger, and channel the compressed airflow form the first heat exchanger to the second compressor.

Abstract: A method for operating a gas turbine engine, including a first compressor, a second compressor, a combustor and a turbine, coupled together in serial flow arrangement, and an intercooler coupled between the first compressor and the second compressor, the intercooler including a first heat exchanger and a second heat exchanger. The method includes channeling compressed airflow from the first compressor to the first heat exchanger, extracting energy from the compressed airflow using a first working fluid flowing through the first heat exchanger to facilitate reducing an operating temperature of the compressed airflow and to facilitate increasing an operating temperature of the first working fluid, and channeling the first working fluid to a process heat exchanger, and channel the compressed airflow form the first heat exchanger to the second compressor.

Abstract: A method for assembling a gas turbine engine assembly includes providing a core gas turbine engine including a high-pressure compressor, a combustor, and a high-pressure turbine, and coupling a low-pressure compressor between the core gas turbine engine and a motor such that the low-pressure compressor is driven only by the motor.

Abstract: A method for operating a gas turbine engine includes channeling compressed airflow discharged from a first compressor through an intercooler having a cooling medium flowing therethrough, channeling a working fluid through the intercooler to facilitate increasing an operating temperature of the working fluid, and channeling the discharged working fluid to a combustor to facilitate increasing an operating efficiency of the gas turbine engine.

Abstract: A method for operating a gas turbine engine, including a first compressor, a second compressor, and a turbine, coupled together in serial flow arrangement. The method includes channeling compressed airflow discharged from the first compressor through an intercooler having a cooling medium flowing therethrough, operating the intercooler such that condensate is formed in the intercooler from the compressed airflow, and channeling the condensate to an inlet of the first or second compressor to facilitate reducing an operating temperature of the gas turbine engine.

Abstract: A system where heat energy is recovered from an intercooled gas turbine engine. This system comprises: (a) at least one gas turbine engine; (b) a compressed air stream that receives energy from the at least one gas turbine engine; (c) at least one intercooler that extracts the energy from the compressed air stream, and (d) at least one heating district. In this system, the at least one intercooler and the at least one heating district is connected by a fluid circulating loop to transfer the extracted energy from the at least one intercooler to the at least one heating district.. Another embodiment involves a method for controlling the ratio of heat energy to output shaft energy removed from an operating intercooled gas turbine engine, which comprises the step of: varying the amount of energy removed by at least one intercooler from a flowing gas stream of the gas turbine engine.

Abstract: A hardware leg for both bracing furniture joints and providing an integrated friction reducing foot pad for supporting the furniture item. The leg has an angled bracket portion mountable to individual panels or a pair of corner adjacent surfaces through screw or nail fastener holes, staple engageable nibs or through the penetratable plates of the bracket itself. The bracket and foot pad can be formed integrally through injection molding from a strong, durable, slick, non-scratching plastic material such as graphite impregnated acetal resin. Further, colored dyes can be selected and mixed with the material during molding to provide a leg color matched to the furniture piece.

Abstract: A caddy for holding a stack of compact disk cases comprises a plurality of trays each shaped and dimensioned to hold a single compact disk case. Each tray is rotatably and slidingly connected to a pair of vertical jambs associated with a case, cabinet or other similar enclosure. The upper front edge of each tray is arcuately and concavely cut to allow viewing of the label-carrying side of the case. The front bottom part of the tray includes a window for viewing a section of the case bottom. Each tray can be flipped upwardly after having translated the entire stack of trays immediately above it along grooves in the supporting jambs.