Abstract: The inventors have examined the means for providing more efficacious miRNA blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of miRNA blocking molecules. These features include the presence of multiple 3? ends and a linker at the 5? ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technology.

Abstract: The inventors have examined the means for providing more efficacious miRNA blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of miRNA blocking molecules. These features include the presence of multiple 3? ends and a linker at the 5? ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technology.

Abstract: The inventors have examined the means for providing more efficacious miRNA blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of miRNA blocking molecules. These features include the presence of multiple 3? ends and a linker at the 5? ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technology.

Abstract: A water treatment system provides treated water to a point of use by removing at least a portion of any hardness-causing species contained in water from a water source, such as municipal water, well water, brackish water and water containing foulants. The water treatment system typically receives water from the water source or a point of entry and purifies the water containing at least some undesirable species before delivering the treated water to a point of use. The water treatment system has a pressurized reservoir system in line with an electrochemical device such as an electrodeionization device. The water treatment system can have a controller for adjusting or regulating at least one operating parameter of the treatment system or a component of the water treatment system. The electrochemical device can be operated at a low current and low flow rate to minimize water splitting or polarization, which minimizes scale formation.

Abstract: A new and distinct cultivar of Rhododendron plant characterized by its pink lavender flowers in terminal rounded trusses, deep mahogany purple winter leaves, and upright, dense growth habit.

Abstract: A water treatment system provides treated water to a point of use by removing at least a portion of any hardness-causing species contained in water from a water source, such as municipal water, well water, brackish water and water containing foulants. The water treatment system typically receives water from the water source or a point of entry and purifies the water containing at least some undesirable species before delivering the treated water to a point of use. The water treatment system has a pressurized reservoir system in line with an electrochemical device such as an electrodeionization device. The water treatment system can have a controller for adjusting or regulating at least one operating parameter of the treatment system or a component of the water treatment system.