Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

Abstract: A method for operating an internal combustion engine (10) that has at least one cylinder row (11a, 11b) with first and second exhaust-gas turbochargers (13a, 13b; 14a, 14b). Charge air is provided by the first exhaust-gas turbocharger (13a, 13b) in single-charger operation, but is provided by the first and second exhaust-gas turbocharger (13a, 13b; 14a, 14b) in two-charger operation. To switch from single-charger to two-charger operation above a load threshold value of the internal combustion engine (10), when a speed of the internal combustion engine (10) reaches or overshoots a threshold value, a charge pressure is increased to build up a torque reserve and a charge pressure reserve and to maintain a driver demand torque. When the charge pressure reaches or overshoots a threshold value, a switch is made from single-charger operation to two-charger operation, and subsequently, the torque reserve and the charge pressure reserve are eliminated.

Abstract: The present invention is directed to compounds that bind to glycoprotein IIb/IIIa and can be used for diagnostic imaging, in particular magnetic resonance imaging of thrombi. The disclosed compounds enable the binding to glycoprotein IIb/IIIa receptor combined with an adequate relaxivity.

Abstract: A method for controlling an internal combustion engine of a motor vehicle includes interrupting a fuel supply in an overrun mode of the motor vehicle above a switch-off rotational speed of the internal combustion engine. The fuel supply is switched on again when a starting rotational speed (n1) is reached or undershot. A brake pressure gradient of a brake system of the motor vehicle is detected and the starting rotational speed (n1) is varied as a function of the brake pressure gradient.

Abstract: A method for controlling an internal combustion engine of a motor vehicle includes interrupting a fuel supply in an overrun mode of the motor vehicle above a switch-off rotational speed of the internal combustion engine. The fuel supply is switched on again when a starting rotational speed (n1) is reached or undershot. A brake pressure gradient of a brake system of the motor vehicle is detected and the starting rotational speed (n1) is varied as a function of the brake pressure gradient.

Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

Abstract: A control device of a motor vehicle having a noise transmission system and an exhaust system, wherein the noise transmission system has, for manipulating an interior noise of the motor vehicle, at least one intake noise transmission device which can be coupled via a first tubular connecting element to an air intake pipe leading to an internal combustion engine, the first tubular connecting element being assigned a switchable shut-off device, and which can be coupled via a second tubular connecting element to a vehicle interior, wherein the exhaust system has at least one switchable shut-off device for manipulating an exterior noise of the motor vehicle, and wherein the control device manipulates the operation of the noise transmission system and of the exhaust system jointly as a function of an actuation of a common operating element by the driver.

Abstract: A control device of a motor vehicle having a noise transmission system and an exhaust system, wherein the noise transmission system has, for manipulating an interior noise of the motor vehicle, at least one intake noise transmission device which can be coupled via a first tubular connecting element to an air intake pipe leading to an internal combustion engine, the first tubular connecting element being assigned a switchable shut-off device, and which can be coupled via a second tubular connecting element to a vehicle interior, wherein the exhaust system has at least one switchable shut-off device for manipulating an exterior noise of the motor vehicle, and wherein the control device manipulates the operation of the noise transmission system and of the exhaust system jointly as a function of an actuation of a common operating element by the driver.

Abstract: In the quantification of bodies, especially bubbles, in ultrasonic diagnosis, the problem exists that the concentration of bodies, especially bubbles, is often so high that the image data that is obtained relative to the visualization becomes saturated, such that a quantification is impossible. To solve this problem, it is proposed that the bodies that are contained in the sectional layers of an object under examination first be excited by means of ultrasound to produce characteristic signals and to pick up these signals, to form data sets from the signals, to convert the data sets into an image of the body arrangement in the object under examination and to determine the number of bodies therefrom, whereby at least two ultrasonic signal sets from overlapping sectional layers in the object under examination are picked up.

Abstract: In the quantification of bodies, especially bubbles, in ultrasonic diagnosis, the problem exists that the concentration of bodies, especially bubbles, is often so high that the image data that is obtained relative to the visualization becomes saturated, such that a quantification is impossible. To solve this problem, it is proposed that the bodies that are contained in the sectional layers of an object under examination first be excited by means of ultrasound to produce characteristic signals and to pick up these signals, to form data sets from the signals, to convert the data sets into an image of the body arrangement in the object under examination and to determine the number of bodies therefrom, whereby at least two ultrasonic signal sets from overlapping sectional layers in the object under examination are picked up.

Abstract: The invention relates to gas-filled microcapsules that consist of functionalized polyalkylcyanoacrylates that are produced by copolymerization of one or more alkylcyanoacrylates with a functional monomer and/or by partial side-chain hydrolysis of a polyalkylcyanoacrylate, as well as a process for the production of gas-filled microcapsules and their use for ultrasound diagnosis.

Abstract: The subject of the invention is a multi-stage process for the production of narrowly-distributed gas-filled microcapsules. In one process step, polymerization of the shell-shaping substance(s) takes place, and in a process step that is separated from it in space and/or time, the formation of the microcapsules by a build-up process takes place. The build-up process is carried out by low-energy defined gas input of the gas that is to be encapsulated with the aid of a porous membrane that has small defined pore openings.

Abstract: The invention relates to a method for obtaining an ultrasonic image of a patient with ultrasonic color Doppler modality with microparticulate ultrasonic contrast agents in regions where the ultrasonic contrast agents are essentially motionless.