Abstract: The invention relates to a device (1) and a method for the optical stimulation of an optically activatable biological sample (3), comprising at least one light source (13; 13?, 13?), which emits light of at least one predetermined wavelength that impinges directly or indirectly on the sample (3). The invention is characterized in that: the at least one light source (13; 13?, 13?) is thermally coupled to a hollow channel section (4); the hollow channel section (4) is part of a fluid circuit through which fluid flows; a temperature-control unit (12) and a conveying pump are arranged along the fluid circuit; and the hollow channel section (4) has at least one limiting wall (5) onto which the optically activatable biological samples (3) are thermally coupled in a direct or indirect manner.

Abstract: The invention relates to a device (1) and a method for the optical stimulation of an optically activatable biological sample (3), comprising at least one light source (13; 13?, 13?), which emits light of at least one predetermined wavelength that impinges directly or indirectly on the sample (3). The invention is characterised in that: the at least one light source (13; 13?, 13?) is thermally coupled to a hollow channel section (4); the hollow channel section (4) is part of a fluid circuit through which fluid flows; a temperature-control unit (12) and a conveying pump are arranged along the fluid circuit; and the hollow channel section (4) has at least one limiting wall (5) onto which the optically activatable biological samples (3) are thermally coupled in a direct or indirect manner.

Abstract: The invention relates to a method for detecting the proximity of at least two biomolecules using branched DNA technology. The assay is called branched proximity hybridization assay.

Abstract: The invention relates to a method for selectively cloning exons in which an ukaryotic genomic DNA fragment to be assayed is cloned into a shuttle vector in a cloning site of an intron flanked by exons. Upon expression in eukaryotic cells, exons present in the cloned DNA are spliced to the exons flanking the intron. After amplification of the cDNA of the expressed mRNA with primers specific for the exons in the vector by PCR, selectively cloned exons can be detected due to the size of the PCR product. The invention also relates to vectors used to carry out the method of the invention as well as to exon libraries.