Patents by Inventor Michael Richard Attwood

Michael Richard Attwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral medicaments
    Patent number: 6372883
    Abstract: The invention is concerned with amino acid derivatives of the formula and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: April 16, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Richard Attwood, David Nigel Hurst, Philip Stephen Jones, Paul Brittain Kay, Tony Michael Raynham, Francis Xavier Wilson
  • Amino acid derivatives
    Patent number: 6018020
    Abstract: The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ;R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl;R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; andR.sup.3 represents hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy;R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl;R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl;R.sup.6 represents hydrogen or lower alkyl;R.sup.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: January 25, 2000
    Assignee: Hoffman-La Roche Inc.
    Inventors: Michael Richard Attwood, David Nigel Hurst, Philip Stephen Jones, Paul Brittain Kay, Tony Michael Raynham, Francis Xavier Wilson
  • Peptidyl inhibitors of viral proteases
    Patent number: 5866684
    Abstract: The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ;R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl;R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; andR.sup.3 represents hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy;R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl;R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl;R.sup.6 represents hydrogen or lower alkyl;R.sup.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: February 2, 1999
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Richard Attwood, David Nigel Hurst, Philip Stephen Jones, Paul Brittain Kay, Tony Michael Raynham, Francis Xavier Wilson