Patents by Inventor Michael Rickey

Michael Rickey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Publication number: 20080069885
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release and a duration of action of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an active agent, such as risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing.
    Type: Application
    Filed: July 13, 2007
    Publication date: March 20, 2008
    Applicants: Alkermes, Inc., Janssen Pharmaceutica, N.V.
    Inventors: Jean Mesens, Michael Rickey, Thomas Atkins
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Publication number: 20080063721
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an active agent, such as risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing.
    Type: Application
    Filed: July 13, 2007
    Publication date: March 13, 2008
    Applicants: Alkermes, Inc., Janssen Pharmaceutica, N.V.
    Inventors: Jean Mesens, Michael Rickey, Thomas Atkins
  • Method for preparing microparticles having a selected polymer molecular weight
    Publication number: 20080058502
    Abstract: A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
    Type: Application
    Filed: July 17, 2007
    Publication date: March 6, 2008
    Applicant: Alkermes, Inc.
    Inventors: Steven Wright, Michael Rickey, J. Ramstack, Shawn Lyons, Joyce Hotz
  • Residual solvent extraction method and microparticles produced thereby
    Publication number: 20080050447
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: July 13, 2007
    Publication date: February 28, 2008
    Applicant: Alkermes, Inc.
    Inventors: Michael Rickey, J. Ramstack, Rajesh Kumar
  • Residual solvent extraction method and microparticles produced thereby
    Publication number: 20080051561
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: July 13, 2007
    Publication date: February 28, 2008
    Applicant: Alkermes, Inc.
    Inventors: Michael Rickey, J. Ramstack, Rajesh Kumar
  • Residual Solvent extraction method and microparticles produced thereby
    Publication number: 20070196499
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: April 19, 2007
    Publication date: August 23, 2007
    Applicant: Alkermes. Inc.
    Inventors: Michael Rickey, J. Ramstack, Rajesh Kumar
  • Polymer-based sustained release device
    Publication number: 20070166352
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: September 14, 2006
    Publication date: July 19, 2007
    Applicant: Alkermes, Inc.
    Inventors: Steven Wright, Troy Christenson, Thean Yeoh, Michael Rickey, Joyce Hotz, Rajesh Kumar, Mark Fineman, Christine Smith, John Ong, David Lokensgard, Henry Costantino
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Publication number: 20060182810
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
    Type: Application
    Filed: March 2, 2006
    Publication date: August 17, 2006
    Applicants: Janssen Pharmaceutica, N.V., Alkermes Controlled Therapeutics Inc. II
    Inventors: Jean Mesens, Michael Rickey, Thomas Atkins
  • Polymer-based sustained release device
    Publication number: 20060110423
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: April 15, 2005
    Publication date: May 25, 2006
    Inventors: Steven Wright, Troy Christenson, Thean Yeoh, Michael Rickey, Joyce Hotz, Rajesh Kumar, Henry Costantino, David Lokensgard, Christine Smith
  • Residual solvent extraction method and microparticles produced thereby
    Publication number: 20060099271
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: December 21, 2005
    Publication date: May 11, 2006
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael Rickey, J. Michael Ramstack, Rajesh Kumar
  • Preparation of biodegradable, biocompatible microparticles containing a biologically active agent
    Publication number: 20050276859
    Abstract: A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to form an emulsion in which the first phase is discontinuous and the second phase is continuous. The discontinuous first phase is separated from the continuous second phase. The residual level of solvent in the discontinuous first phase is reduced to less than about 2% by weight.
    Type: Application
    Filed: May 16, 2005
    Publication date: December 15, 2005
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael Rickey, J. Ramstack, Danny Lewis
  • Polymer-based sustained release device
    Publication number: 20050271702
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Application
    Filed: April 13, 2005
    Publication date: December 8, 2005
    Inventors: Steven Wright, Troy Christensen, Thean Yeoh, Michael Rickey, Joyce Hotz, Rajesh Kumar, Henry Costantino
  • Residual solvent extraction method and microparticles produced thereby
    Publication number: 20050079224
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Application
    Filed: October 4, 2004
    Publication date: April 14, 2005
    Applicant: Alkermes Controlled Therapeutics Inc. II
    Inventors: Michael Rickey, J. Ramstack, Rajesh Kumar
  • Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
    Publication number: 20050025828
    Abstract: Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes microparticles that exhibit diffusional release and microparticles that exhibit biodegradation release.
    Type: Application
    Filed: August 18, 2004
    Publication date: February 3, 2005
    Applicants: Alkermes Controlled Therapeutics Inc. II, Janssen Pharmaceutica
    Inventors: Jean Mesens, Michael Rickey, Thomas Atkins