Abstract: Applicator devices (1), kits, systems, and methods of using such devices for treating one or more body surface conditions (e.g., warts, Molluscum contagiosum, conjunctivitis, otitis) are provided. The applicator device facilitates topical administration of a controllable amount of a pharmaceutical composition to a desired area of an affected body surface (e.g., skin, eye, ear, nose, mouth, anus, vagina). The applicator device includes an ampule (40) containing the pharmaceutical composition, the ampule being positioned within a tube (50). Squeezing the tube breaks the ampule, releasing the pharmaceutical composition. The applicator device includes a filter (30) that permits passage of fluid and inhibits passage of broken ampule shards. The applicator device includes a dispensing tip (20) through which the pharmaceutical composition passes.

Abstract: Methods of treating one or more skin lesions using cantharidin as well as associated compositions, treatment regimens, kits, devices, and systems are provided. A method of treating a subject having one or more skin lesions may involve administering a composition comprising cantharidin to one or more skin lesions. The method may allow for the efficacious treatment of the skin lesion(s) with minimal or no adverse side effects (e.g., severe adverse side effects, permanent damage of the dermal tissue, scarring, excessive blistering of skin surrounding the lesion, elevated plasma cantharidin concentration, systemic exposure to cantharidin). The efficacy and/or safety of the treatment may be due, to certain features of the composition and/or prolonged exposure of the skin lesion(s) to cantharidin. The methods described herein may be used for a wide variety of cutaneous disorders, including skin disorders that primarily affect the epidermis of skin.

Abstract: The present disclosure describes a dosing regimen of an IL-10F129S expression construct for treating an inflammatory joint disease (e.g., osteoarthritis) in a subject. Methods are provided for treating an inflammatory joint disease in a subject by injecting a first dose and second dose of a composition comprising an IL-10F129S expression construct into an inflamed joint of the subject according to a dosing regimen wherein the two doses of the expression construct are administered to a subject approximately 150-360 days apart. The present disclosure also provides kits comprising a first and second dose of an IL-10F129S expression construct. The kits may be useful for treating an inflammatory joint disease in a subject.

Abstract: A method of monitoring a machine is described. The machine includes a mechanical system moved by a motor, where the mechanical system has more than two components coupled to each other. The two or more components move differently when the mechanical system is driven by the motor. The method includes repeatedly determining one movement factor of one of the components, and repeatedly determining one dynamic factor of one of the components. The movement factors of the remaining components are then calculated via a model of the mechanical system, and separate parameters for the components of the mechanical system are determined from the movement factor, the dynamic factor, and the calculated movement factors.

Abstract: Methods of treating one or more skin lesions using cantharidin as well as associated compositions, treatment regimens, kits, devices, and systems are provided. A method of treating a subject having one or more skin lesions may involve administering a composition comprising cantharidin to one or more skin lesions. The method may allow for the efficacious treatment of the skin lesion(s) with minimal or no adverse side effects (e.g., severe adverse side effects, permanent damage of the dermal tissue, scarring, excessive blistering of skin surrounding the lesion, elevated plasma cantharidin concentration, systemic exposure to cantharidin). The efficacy and/or safety of the treatment may be due, to certain features of the composition and/or prolonged exposure of the skin lesion(s) to cantharidin. The methods described herein may be used for a wide variety of cutaneous disorders, including skin disorders that primarily affect the epidermis of skin.

Abstract: Methods of treating one or more skin lesions using cantharidin as well as associated compositions, treatment regimens, kits, devices, and systems are provided. A method of treating a subject having one or more skin lesions may involve administering a composition comprising cantharidin to one or more skin lesions. The method may allow for the efficacious treatment of the skin lesion(s) with minimal or no adverse side effects (e.g., severe adverse side effects, permanent damage of the dermal tissue, scarring, excessive blistering of skin surrounding the lesion, elevated plasma cantharidin concentration, systemic exposure to cantharidin). The efficacy and/or safety of the treatment may be due, to certain features of the composition and/or prolonged exposure of the skin lesion(s) to cantharidin. The methods described herein may be used for a wide variety of cutaneous disorders, including skin disorders that primarily affect the epidermis of skin.

Abstract: A head protection airbag module comprising a tubular inflator, a holder for the inflator and an airbag which is in fluid communication with the inflator and is folded to form a package, characterized by a guide element for the airbag which is arranged on the holder and includes a guide tongue extending into the airbag package.

Abstract: Applicator devices (1), kits, systems, and methods of using such devices for treating one or more body surface conditions (e.g., warts, Molluscum contagiosum, conjunctivitis, otitis) are provided. The applicator device facilitates topical administration of a controllable amount of a pharmaceutical composition to a desired area of an affected body surface (e.g., skin, eye, ear, nose, mouth, anus, vagina). The applicator device includes an ampule (40) containing the pharmaceutical composition, the ampule being positioned within a tube (50). Squeezing the tube breaks the ampule, releasing the pharmaceutical composition. The applicator device includes a filter (30) that permits passage of fluid and inhibits passage of broken ampule shards. The applicator device includes a dispensing tip (20) through which the pharmaceutical composition passes.

Abstract: A head protection airbag module comprising a tubular inflator, a holder for the inflator and an airbag which is in fluid communication with the inflator and is folded to form a package, characterized by a guide element for the airbag which is arranged on the holder and includes a guide tongue extending into the airbag package.

Abstract: Beginning on a starting area on a surface of a digital model, a layered subdivision of the model takes place to produce a three-dimensional object. Positioning of the layers on the starting area is based on calculation of a distance field, which assigns to each point of the model volume a shortest distance within the volume to the nearest starting area. For each discrete point of a layer defined by a distance field an orientation of a processing head is determined. The surface normal of the layer is calculated or gradient vectors of the distance field are calculated, which show a direction of the steepest rise in distances for the discrete point. Shape and distribution of layers conform to the shape of the digital model. The sequence for the adaptive construction results from the assignment of the layers to distance values, beginning with a lowest distance value in ascending order.

Abstract: The invention relates to a method of monitoring a machine in which a mechanical system is moved by a motor, wherein the mechanical system comprises more than two components coupled to one another, wherein one of the components comprises the motor, wherein at least the two components move differently when the motor drives the mechanical system, and wherein at least one movement factor of one of the components of the mechanical system is determined repeatedly; at least one dynamic factor of one of the components of the mechanical system is determined repeatedly; the movement factors of the remaining components of the mechanical system are calculated by means of a model of the mechanical system; and separate mechanical parameters for the components of the mechanical system are determined from the determined movement factor, from the determined dynamic factor, and from the calculated movement factors.

Abstract: Methods of treating one or more skin lesions using cantharidin as well as associated compositions, treatment regimens, kits, devices, and systems are provided. A method of treating a subject having one or more skin lesions may involve administering a composition comprising cantharidin to one or more skin lesions. The method may allow for the efficacious treatment of the skin lesion(s) with minimal or no adverse side effects (e.g., severe adverse side effects, permanent damage of the dermal tissue, scarring, excessive blistering of skin surrounding the lesion, elevated plasma cantharidin concentration, systemic exposure to cantharidin). The efficacy and/or safety of the treatment may be due, to certain features of the composition and/or prolonged exposure of the skin lesion(s) to cantharidin. The methods described herein may be used for a wide variety of cutaneous disorders, including skin disorders that primarily affect the epidermis of skin.

Abstract: A process for the production of synthesis gas from coke is described herein. The process comprises the steps of: (a) subjecting hard coal to dry pyrolysis, resulting in the production of a gas mixture containing hydrogen, methane, nitrogen and carbon monoxide as major constituents and carbon sulphides as minor constituents; (b) subjecting the gas mixture to hydrogenation at a temperature in the range of 200 to 280° C. over a sulphidic cobalt molybdenum catalyst provided on an aluminium oxide carrier material; and (c) separating the hydrogen sulphide obtained from hydrogenation from the gas mixture.

Abstract: The invention relates to a bearing component, comprising a base body (2) and an opening (3) which is formed in the base body (2) and on which an internal bearing face is formed, the internal bearing face having a diamond coating (4), and the diamond coating (4) having elongate depressions (42) extending substantially in the longitudinal direction (X-X) of the opening.

Abstract: The invention relates to a bearing component, comprising a base body (2) and an opening (3) which is formed in the base body (2) and on which an internal bearing face is formed, the internal bearing face having a diamond coating (4), and the diamond coating (4) having elongate depressions (42) extending substantially in the longitudinal direction (X-X) of the opening.