Patents by Inventor Michael Rigby
Michael Rigby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250066421Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: ApplicationFiled: October 4, 2024Publication date: February 27, 2025Inventors: Paul Beswick, Liuhong Chen, Gemma Elizabeth Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby, Stephen Blakemore, Tara Gelb, Nicholas Keen
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Publication number: 20250051392Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: ApplicationFiled: August 7, 2024Publication date: February 13, 2025Applicant: BicycleTx LimitedInventors: Stephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
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Publication number: 20250002536Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: ApplicationFiled: August 13, 2024Publication date: January 2, 2025Applicant: BicycleTx LimitedInventors: Stephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
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Publication number: 20240382605Abstract: Provided herein are oligomeric compounds comprising a bicycle ligand and a modified oligonucleotide. This compound may comprise a bicycle ligand as the cell-targeting moiety, and may also comprise a conjugate linker to connect the bicycle ligand and modified oligonucleotide. This compound may be used in conjunction with a pharmaceutically acceptable salt.Type: ApplicationFiled: September 29, 2022Publication date: November 21, 2024Applicants: Ionis Pharmaceuticals, Inc., BicycleTx LimitedInventors: Punit P. Seth, Michael Oestergaard, Michele Carrer, Michael Tanowitz, Michael Rigby, Michael Skynner, Steven Stanway, Liudvikas Urbonas, Katerine Van Rietschoten
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Patent number: 11970555Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.Type: GrantFiled: November 12, 2021Date of Patent: April 30, 2024Assignee: BicycleTx LimitedInventors: Ellen Gowans, Gemma Elizabeth Mudd, Michael Rigby, Punit Seth, Michael Skynner, Steven Stanway, Liudvikas Urbonas, Katerine Van Rietschoten
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Patent number: 11912792Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: GrantFiled: August 17, 2022Date of Patent: February 27, 2024Assignee: BicycleTx LimitedInventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
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Patent number: 11453702Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: GrantFiled: September 30, 2021Date of Patent: September 27, 2022Assignee: BICYCLETX LIMITEDInventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
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Patent number: 11180531Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: GrantFiled: June 20, 2019Date of Patent: November 23, 2021Assignee: BicycleTx LimitedInventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
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Patent number: 10537933Abstract: A container closure includes a generally planar body having a product side and a customer side. The body includes a container opening. The container opening includes a shifted material line.Type: GrantFiled: September 6, 2017Date of Patent: January 21, 2020Assignee: Stolle Machinery Company, LLCInventors: Aaron Emmanuel Carstens, Patrick Kevin McCarty, Justin Michael Rigby
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Publication number: 20190389906Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.Type: ApplicationFiled: June 20, 2019Publication date: December 26, 2019Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
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Publication number: 20180071810Abstract: A container closure includes a generally planar body having a product side and a customer side. The body includes a container opening. The container opening includes a shifted material line.Type: ApplicationFiled: September 6, 2017Publication date: March 15, 2018Applicant: Stolle Machinery Company, LLCInventors: Aaron Emmanuel Carstens, Patrick Kevin McCarty, Justin Michael Rigby
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Publication number: 20170280762Abstract: A daily intake formulated for breastfeeding women containing iron, vitamin B6, iodine, vitamin D, and herbs and galactogogues that support milk production.Type: ApplicationFiled: June 20, 2017Publication date: October 5, 2017Inventors: Taryn Louise Forrelli, Graham Robert Michael Rigby, Paul Schulick
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Publication number: 20160073666Abstract: A daily intake formulated for breastfeeding women containing iron, vitamin B6, iodine, vitamin D, and herbs and galactogogues that support milk production.Type: ApplicationFiled: September 16, 2014Publication date: March 17, 2016Inventors: Taryn Louise Forrelli, Graham Robert Michael Rigby, Paul Schulick
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Patent number: 8375766Abstract: An apparatus (7) for monitoring particles flowing in a stack (6), comprises: an electrical-interaction monitor (1) operable to provide a signal (300) resulting from electrical interaction of the particles with the monitor (1). a scattered-light monitor (10) operable to provide a signal (310) resulting from detection of light scattered from the particles, and a controller (320) arranged to alter the calibration of the electrical-interaction monitor 1 in response to changes in the relative magnitude of the electrical-interaction (signal 300) and the scattered-light signal (310).Type: GrantFiled: December 19, 2007Date of Patent: February 19, 2013Assignee: PCME LimitedInventors: Michael Rigby, William John Averdieck
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Patent number: 8134706Abstract: An instrument (10) for monitoring particles (67) flowing in a stack, includes: (a) a light source for providing a light beam (60); (b) a sensor/and (c) a probe housing. The housing comprises: (i) a mount (25); (ii) a proximal portion (30) including a first aperture (35) through which in use the light beam (60) exits; (iii) a distal portion (50), including a second aperture (55) through which the light beam (60) enters after having been scattered from particles (67) flowing in the stack, and a focusing mirror (70) arranged to reflect and focus the scattered light (90); (iv) a medial portion (40), connecting the distal portion (50) to the proximal portion (30); (v) a waveguide (80), passing from the distal portion (50) through the medial portion (40) and the proximal portion (30) to the sensor and arranged to guide to the sensor the light (90) reflected and focused by the focusing mirror (70).Type: GrantFiled: February 2, 2006Date of Patent: March 13, 2012Assignee: PCME LimitedInventors: John Rogers, Michael Rigby
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Publication number: 20110134427Abstract: An instrument (10) for monitoring particles (67) flowing in a stack, includes: (a) a light source for providing a light beam (60); (b) a sensor/and (c) a probe housing. The housing comprises: (i) a mount (25); (ii) a proximal portion (30) including a first aperture (35) through which in use the light beam (60) exits; (iii) a distal portion (50), including a second aperture (55) through which the light beam (60) enters after having been scattered from particles (67) flowing in the stack, and a focusing mirror (70) arranged to reflect and focus the scattered light (90); (iv) a medial portion (40), connecting the distal portion (50) to the proximal portion (30); (v) a waveguide (80), passing from the distal portion (50) through the medial portion (40) and the proximal portion (30) to the sensor and arranged to guide to the sensor the light (90) reflected and focused by the focusing mirror (70).Type: ApplicationFiled: February 2, 2006Publication date: June 9, 2011Applicant: PCME LIMITEDInventors: John Rogers, Michael Rigby
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Publication number: 20100101300Abstract: An apparatus (7) for monitoring particles flowing in a stack (6), comprises: an electrical-interaction monitor (1) operable to provide a signal (300) resulting from electrical interaction of the particles with the monitor (1). a scattered-light monitor (10) operable to provide a signal (310) resulting from detection of light scattered from the particles, and a controller (320) arranged to alter the calibration of the electrical-interaction monitor 1 in response to changes in the relative magnitude of the electrical-interaction (signal 300) and the scattered-light signal (310).Type: ApplicationFiled: December 19, 2007Publication date: April 29, 2010Applicant: PCME LIMITEDInventors: Michael Rigby, William John Averdieck
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Publication number: 20090180501Abstract: A method of controlling a laser is provided for generating an optical output. The method includes the step of making a change to an electrical input to the laser so as to move the optical output of the laser towards a target frequency, and also includes the step of changing the temperature of the laser in relation to the change in the electrical input or the movement of the optical output. The method further includes the step of making further changes to the electrical input as the temperature of the laser is changed so as to maintain the optical output of the laser at the target frequency.Type: ApplicationFiled: December 19, 2006Publication date: July 16, 2009Applicant: Bookham Technology PLCInventors: Richard Jonathon Barlow, Giacinto Busico, Lee Nelson, Michael Rigby-Jones
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Publication number: 20090163544Abstract: This invention relates to the treatment or prevention of nausea and/or vomiting by the administration of a NK-3 receptor antagonist.Type: ApplicationFiled: March 31, 2006Publication date: June 25, 2009Inventors: Michael Rigby, Frederick David
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Patent number: 6489775Abstract: A particle detector for detecting particles flowing in a duct has a first triboelectric probe (5) for detecting the particles and a second triboelectric probe (3) for detecting a signal generated by contaminants on the particle detector. The presence of signal-generating contaminants on the particle detector will result in an error signal on the first probe (5) and a signal on the second probe (3). Therefore, the presence of a signal on the second probe (3) will indicate that the signal appearing on the first probe (5) includes an error signal. If the ratio of the magnitude of the signal generated on the second probe (3) to the magnitude of the signal generated on the first probe (5) exceeds a certain pre-defined limit, cleaning of the detector will be required.Type: GrantFiled: December 20, 2000Date of Patent: December 3, 2002Assignee: PCME Ltd.Inventors: Michael Rigby, Gary Paul Cullen