Patents by Inventor Michael Rigby

Michael Rigby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250066421
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: October 4, 2024
    Publication date: February 27, 2025
    Inventors: Paul Beswick, Liuhong Chen, Gemma Elizabeth Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby, Stephen Blakemore, Tara Gelb, Nicholas Keen
  • Publication number: 20250051392
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: August 7, 2024
    Publication date: February 13, 2025
    Applicant: BicycleTx Limited
    Inventors: Stephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
  • Publication number: 20250002536
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: August 13, 2024
    Publication date: January 2, 2025
    Applicant: BicycleTx Limited
    Inventors: Stephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
  • Publication number: 20240382605
    Abstract: Provided herein are oligomeric compounds comprising a bicycle ligand and a modified oligonucleotide. This compound may comprise a bicycle ligand as the cell-targeting moiety, and may also comprise a conjugate linker to connect the bicycle ligand and modified oligonucleotide. This compound may be used in conjunction with a pharmaceutically acceptable salt.
    Type: Application
    Filed: September 29, 2022
    Publication date: November 21, 2024
    Applicants: Ionis Pharmaceuticals, Inc., BicycleTx Limited
    Inventors: Punit P. Seth, Michael Oestergaard, Michele Carrer, Michael Tanowitz, Michael Rigby, Michael Skynner, Steven Stanway, Liudvikas Urbonas, Katerine Van Rietschoten
  • Patent number: 11970555
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: April 30, 2024
    Assignee: BicycleTx Limited
    Inventors: Ellen Gowans, Gemma Elizabeth Mudd, Michael Rigby, Punit Seth, Michael Skynner, Steven Stanway, Liudvikas Urbonas, Katerine Van Rietschoten
  • Patent number: 11912792
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Grant
    Filed: August 17, 2022
    Date of Patent: February 27, 2024
    Assignee: BicycleTx Limited
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Patent number: 11453702
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: September 27, 2022
    Assignee: BICYCLETX LIMITED
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Patent number: 11180531
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 23, 2021
    Assignee: BicycleTx Limited
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Patent number: 10537933
    Abstract: A container closure includes a generally planar body having a product side and a customer side. The body includes a container opening. The container opening includes a shifted material line.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: January 21, 2020
    Assignee: Stolle Machinery Company, LLC
    Inventors: Aaron Emmanuel Carstens, Patrick Kevin McCarty, Justin Michael Rigby
  • Publication number: 20190389906
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: June 20, 2019
    Publication date: December 26, 2019
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Publication number: 20180071810
    Abstract: A container closure includes a generally planar body having a product side and a customer side. The body includes a container opening. The container opening includes a shifted material line.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 15, 2018
    Applicant: Stolle Machinery Company, LLC
    Inventors: Aaron Emmanuel Carstens, Patrick Kevin McCarty, Justin Michael Rigby
  • Publication number: 20170280762
    Abstract: A daily intake formulated for breastfeeding women containing iron, vitamin B6, iodine, vitamin D, and herbs and galactogogues that support milk production.
    Type: Application
    Filed: June 20, 2017
    Publication date: October 5, 2017
    Inventors: Taryn Louise Forrelli, Graham Robert Michael Rigby, Paul Schulick
  • Publication number: 20160073666
    Abstract: A daily intake formulated for breastfeeding women containing iron, vitamin B6, iodine, vitamin D, and herbs and galactogogues that support milk production.
    Type: Application
    Filed: September 16, 2014
    Publication date: March 17, 2016
    Inventors: Taryn Louise Forrelli, Graham Robert Michael Rigby, Paul Schulick
  • Patent number: 8375766
    Abstract: An apparatus (7) for monitoring particles flowing in a stack (6), comprises: an electrical-interaction monitor (1) operable to provide a signal (300) resulting from electrical interaction of the particles with the monitor (1). a scattered-light monitor (10) operable to provide a signal (310) resulting from detection of light scattered from the particles, and a controller (320) arranged to alter the calibration of the electrical-interaction monitor 1 in response to changes in the relative magnitude of the electrical-interaction (signal 300) and the scattered-light signal (310).
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: February 19, 2013
    Assignee: PCME Limited
    Inventors: Michael Rigby, William John Averdieck
  • Patent number: 8134706
    Abstract: An instrument (10) for monitoring particles (67) flowing in a stack, includes: (a) a light source for providing a light beam (60); (b) a sensor/and (c) a probe housing. The housing comprises: (i) a mount (25); (ii) a proximal portion (30) including a first aperture (35) through which in use the light beam (60) exits; (iii) a distal portion (50), including a second aperture (55) through which the light beam (60) enters after having been scattered from particles (67) flowing in the stack, and a focusing mirror (70) arranged to reflect and focus the scattered light (90); (iv) a medial portion (40), connecting the distal portion (50) to the proximal portion (30); (v) a waveguide (80), passing from the distal portion (50) through the medial portion (40) and the proximal portion (30) to the sensor and arranged to guide to the sensor the light (90) reflected and focused by the focusing mirror (70).
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: March 13, 2012
    Assignee: PCME Limited
    Inventors: John Rogers, Michael Rigby
  • Publication number: 20110134427
    Abstract: An instrument (10) for monitoring particles (67) flowing in a stack, includes: (a) a light source for providing a light beam (60); (b) a sensor/and (c) a probe housing. The housing comprises: (i) a mount (25); (ii) a proximal portion (30) including a first aperture (35) through which in use the light beam (60) exits; (iii) a distal portion (50), including a second aperture (55) through which the light beam (60) enters after having been scattered from particles (67) flowing in the stack, and a focusing mirror (70) arranged to reflect and focus the scattered light (90); (iv) a medial portion (40), connecting the distal portion (50) to the proximal portion (30); (v) a waveguide (80), passing from the distal portion (50) through the medial portion (40) and the proximal portion (30) to the sensor and arranged to guide to the sensor the light (90) reflected and focused by the focusing mirror (70).
    Type: Application
    Filed: February 2, 2006
    Publication date: June 9, 2011
    Applicant: PCME LIMITED
    Inventors: John Rogers, Michael Rigby
  • Publication number: 20100101300
    Abstract: An apparatus (7) for monitoring particles flowing in a stack (6), comprises: an electrical-interaction monitor (1) operable to provide a signal (300) resulting from electrical interaction of the particles with the monitor (1). a scattered-light monitor (10) operable to provide a signal (310) resulting from detection of light scattered from the particles, and a controller (320) arranged to alter the calibration of the electrical-interaction monitor 1 in response to changes in the relative magnitude of the electrical-interaction (signal 300) and the scattered-light signal (310).
    Type: Application
    Filed: December 19, 2007
    Publication date: April 29, 2010
    Applicant: PCME LIMITED
    Inventors: Michael Rigby, William John Averdieck
  • Publication number: 20090180501
    Abstract: A method of controlling a laser is provided for generating an optical output. The method includes the step of making a change to an electrical input to the laser so as to move the optical output of the laser towards a target frequency, and also includes the step of changing the temperature of the laser in relation to the change in the electrical input or the movement of the optical output. The method further includes the step of making further changes to the electrical input as the temperature of the laser is changed so as to maintain the optical output of the laser at the target frequency.
    Type: Application
    Filed: December 19, 2006
    Publication date: July 16, 2009
    Applicant: Bookham Technology PLC
    Inventors: Richard Jonathon Barlow, Giacinto Busico, Lee Nelson, Michael Rigby-Jones
  • Publication number: 20090163544
    Abstract: This invention relates to the treatment or prevention of nausea and/or vomiting by the administration of a NK-3 receptor antagonist.
    Type: Application
    Filed: March 31, 2006
    Publication date: June 25, 2009
    Inventors: Michael Rigby, Frederick David
  • Patent number: 6489775
    Abstract: A particle detector for detecting particles flowing in a duct has a first triboelectric probe (5) for detecting the particles and a second triboelectric probe (3) for detecting a signal generated by contaminants on the particle detector. The presence of signal-generating contaminants on the particle detector will result in an error signal on the first probe (5) and a signal on the second probe (3). Therefore, the presence of a signal on the second probe (3) will indicate that the signal appearing on the first probe (5) includes an error signal. If the ratio of the magnitude of the signal generated on the second probe (3) to the magnitude of the signal generated on the first probe (5) exceeds a certain pre-defined limit, cleaning of the detector will be required.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: December 3, 2002
    Assignee: PCME Ltd.
    Inventors: Michael Rigby, Gary Paul Cullen