Patents by Inventor Michael Rigby

Michael Rigby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250066421
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: October 4, 2024
    Publication date: February 27, 2025
    Inventors: Paul Beswick, Liuhong Chen, Gemma Elizabeth Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby, Stephen Blakemore, Tara Gelb, Nicholas Keen
  • Publication number: 20250051392
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: August 7, 2024
    Publication date: February 13, 2025
    Applicant: BicycleTx Limited
    Inventors: Stephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
  • Publication number: 20250002536
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: August 13, 2024
    Publication date: January 2, 2025
    Applicant: BicycleTx Limited
    Inventors: Stephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
  • Publication number: 20240400616
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: January 30, 2024
    Publication date: December 5, 2024
    Inventors: Paul BESWICK, Liuhong CHEN, Gemma MUDD, Peter PARK, Katerine VAN RIETSCHOTEN, Michael RIGBY
  • Publication number: 20240391959
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.
    Type: Application
    Filed: March 19, 2024
    Publication date: November 28, 2024
    Inventors: Ellen GOWANS, Gemma Elizabeth MUDD, Michael RIGBY, Punit SETH, Michael SKYNNER, Steven STANWAY, Liudvikas URBONAS, Katerine VAN RIETSCHOTEN
  • Publication number: 20240382605
    Abstract: Provided herein are oligomeric compounds comprising a bicycle ligand and a modified oligonucleotide. This compound may comprise a bicycle ligand as the cell-targeting moiety, and may also comprise a conjugate linker to connect the bicycle ligand and modified oligonucleotide. This compound may be used in conjunction with a pharmaceutically acceptable salt.
    Type: Application
    Filed: September 29, 2022
    Publication date: November 21, 2024
    Applicants: Ionis Pharmaceuticals, Inc., BicycleTx Limited
    Inventors: Punit P. Seth, Michael Oestergaard, Michele Carrer, Michael Tanowitz, Michael Rigby, Michael Skynner, Steven Stanway, Liudvikas Urbonas, Katerine Van Rietschoten
  • Publication number: 20240192568
    Abstract: In some implementations, a controller may apply a set of phase dithers to a first inner Mach-Zehnder (MZ) interferometer and a second inner MZ interferometer, the first inner MZ interferometer and the second inner MZ interferometer being included in an outer MZ interferometer, the set of phase dithers including a first in-phase dither state and a second in-phase dither state and including a first anti-phase dither state and a second anti-phase dither state. The controller may determine an initial error term based at least in part on the set of phase dithers. The controller may adjust, based on the initial error term, the outer MZ interferometer to a target phase associated with a target error term, wherein respective branches of at least one of the first MZ interferometer or the second MZ interferometer are adjusted differentially.
    Type: Application
    Filed: March 7, 2023
    Publication date: June 13, 2024
    Inventors: Brian GARRETT, Amyas HOLROYD, Chalani ABEYWARDENA, Michael RIGBY-JONES
  • Publication number: 20240173422
    Abstract: The present invention relates to drug conjugates comprising at least two polypeptides which are each covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also relates to pharmaceutical compositions comprising said drug conjugates and to the use of said drug conjugates in preventing, suppressing or treating diseases, such as those which may be alleviated by cell death, in particular diseases characterised by defective cell types, proliferative disorders such as cancer and autoimmune disorders such as rheumatoid arthritis.
    Type: Application
    Filed: October 15, 2020
    Publication date: May 30, 2024
    Inventors: Paul Beswick, Gemma MUDD, Michael RIGBY
  • Patent number: 11970555
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: April 30, 2024
    Assignee: BicycleTx Limited
    Inventors: Ellen Gowans, Gemma Elizabeth Mudd, Michael Rigby, Punit Seth, Michael Skynner, Steven Stanway, Liudvikas Urbonas, Katerine Van Rietschoten
  • Patent number: 11912792
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Grant
    Filed: August 17, 2022
    Date of Patent: February 27, 2024
    Assignee: BicycleTx Limited
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Publication number: 20230287047
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: August 17, 2022
    Publication date: September 14, 2023
    Inventors: Paul BESWICK, Liuhong CHEN, Gemma MUDD, Peter PARK, Katerine VAN RIETSCHOTEN, Michael RIGBY
  • Publication number: 20230233698
    Abstract: The present invention relates to a Bicycle toxin conjugate BT5528, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and uses thereof.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 27, 2023
    Inventors: Gavin BENNETT, Stephen BLAKEMORE, Carly CAMPBELL, Michael RIGBY
  • Publication number: 20230181749
    Abstract: The present invention relates to a Bicycle toxin conjugate BT8009, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and uses thereof. In one embodiment, the pharmaceutical composition comprises BT8009, histidine, sucrose and Polysorbate 20. In another embodiment, the pharmaceutical composition is for use in treating an advanced solid tumor malignancy associated with Nectin-4-expression in a patient, preferably in combination with Nivolumab.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Inventors: Amy Katherine DICKSON, Darren LIMB, Lisa MAHNKE, Michael RIGBY, Terrence Allen WEST, David WITTY
  • Patent number: 11453702
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: September 27, 2022
    Assignee: BICYCLETX LIMITED
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Publication number: 20220194988
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.
    Type: Application
    Filed: November 12, 2021
    Publication date: June 23, 2022
    Inventors: Ellen GOWANS, Gemma Elizabeth MUDD, Michael RIGBY, Punit SETH, Michael SKYNNER, Steven STANWAY, Liudvikas URBONAS, Katerine VAN RIETSCHOTEN
  • Publication number: 20220089643
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: September 30, 2021
    Publication date: March 24, 2022
    Inventors: Paul BESWICK, Liuhong CHEN, Gemma MUDD, Peter PARK, Katerine VAN RIETSCHOTEN, Michael RIGBY
  • Patent number: 11180531
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 23, 2021
    Assignee: BicycleTx Limited
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
  • Publication number: 20210269480
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4.The invention also includes drug conjugates comprising said peptides,conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 2, 2021
    Inventors: Paul BESWICK, Liuhong CHEN, Gemma Elizabeth MUDD, Peter PARK, Katerine VAN RIETSCHOTEN, Michael RIGBY
  • Patent number: 10537933
    Abstract: A container closure includes a generally planar body having a product side and a customer side. The body includes a container opening. The container opening includes a shifted material line.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: January 21, 2020
    Assignee: Stolle Machinery Company, LLC
    Inventors: Aaron Emmanuel Carstens, Patrick Kevin McCarty, Justin Michael Rigby
  • Publication number: 20190389906
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
    Type: Application
    Filed: June 20, 2019
    Publication date: December 26, 2019
    Inventors: Paul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby