Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: A drilling rig 10 supports a drill string 11 within a borehole 12. An acoustic receiver 14 is associated with a drill bit 13 connected to the end of the drill string 11. An acoustic source 16, such as an airgun, is located at the earth's surface 17 some distance from the rig 10. In operation, the acoustic source 16 is controlled to transmit an acoustic pulse downwards into the rock formations surrounding the borehole 12. The acoustic energy travelling on a path 18 reaches the rock in contact with the drill bit 13 which is thereby detected by the acoustic receiver 14. Boundaries 20 and 23 in the rock formations are detected and their positions determined by receiving signals from the source 16 after reflection by the boundaries 20 and 23. Time-depth check-shots may be obtained by timing acoustic propagation along either path 18 or path 27. A Vertical Seismic Profile can be obtained by performing measurements with the drill bit 13 at different depths in the borehole.