Abstract: A retention system may comprise a bracket, a bar system, a seal and a bonded washer. The bracket may have a first portion and a second portion. The first portion and the second portion may be operatively coupled together at an angle ?. The bracket may also have a texture. The bracket may define a mounting surface. The bar system may comprise a bar installable in the bracket. The seal may be installable in the bracket and disposed beneath the mounting surface. The bonded washer may be installable on and compressible against the mounting surface.

Abstract: The present invention relates to methods of enriching target single-stranded nucleic acids in a mixed population of single-stranded nucleic acids. The method involves protecting the target single-stranded nucleic acids and using a 5? exonuclease to digest the non-target single-stranded nucleic acids. The invention also relates to methods of cloning target single-stranded nucleic acids into vectors, and to associated compositions and kits.

Abstract: The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2?, R3, R4, X1, X2, X3, X4, Q, and n are described herein.

Abstract: A method of producing a densified carbon fiber reinforced carbon (carbon/carbon) component includes placing a carbon/carbon preform and preform heater(s) into a reactor vessel with an immersing quantity of a precursor liquid (e.g., hydrocarbon). The reactor vessel includes a condenser for condensing precursor gases (e.g., carbonaceous gases) produced during densification and thereby maintain a thermodynamic equilibrium. Electrical current is supplied to the preform heater over a multi-hour period of densification in which the precursor liquid is continually boiled and the precursor gases continually produced. The current is sufficient to maintain the preform at a densification temperature above a precursor cracking temperature, thereby causing the precursor gases to be diffused into the preform and dissociated gas species to be deposited. Densification begins within the preform and advances outwardly along a densification front until completion.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: Various technologies for reducing or increasing a speed of a personal transportation vehicle by rotating its handlebar. Some technologies provide this functionality based on a stem, a rack, and a brake. Some technologies provide this functionality based on a worm gear, a stem, and a brake. Some technologies provide this functionality based on a cam, a cam follower, a rod, a stem, and a brake.

Abstract: In a method for designing and producing a mechanical component for an application, application requirements and application variables are provided to an optimization engine, wherein the application requirements describe required features and the application variables describe features that can be varied to arrive at an optimal design. The optimization engine is operated using the application requirements and application variables to produce a manufacturing specification for the mechanical component, which includes specific values for the application variables corresponding to an optimal design. The mechanical component is then manufactured according to the manufacturing specification. The optimization engine may use a genetic algorithm to generate and evaluate a large number of candidate designs and thus quickly and efficiently produce superior application-specific components.

Abstract: A system for energy conversion including a closed cycle engine containing a volume of working fluid is provided. The engine includes a double-ended piston assembly including a pair of pistons coupled to a connection member. An expansion chamber is separated from a compression chamber by the piston. The engine defines an outer end and an inner end relative to a lateral extension of the piston assembly. A heater body is positioned thermally proximal to the expansion chamber and thermally distal to the compression chamber, and the heater body is positioned at the outer end of the engine. A load device is operably coupled to the piston assembly at the inner end of the engine. The load device is positioned between the pair of pistons of the piston assembly.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Abstract: A gaming machine presents a game in which an upgradeable object accrues value. The gaming machine includes a player input interface, a credit input mechanism and a game controller configured to perform operations. The game controller presents a primary game, in which a plurality of reels are simulated, spins the plurality of simulated reels each time a player makes a wager, determines, a number of scatter symbols stopped and displayed from the reels, triggers, a bonus game in which an appearance of the upgradeable game object is upgradeable and in which a credit value associated with the upgradeable game object is upgradeable, upgrades the appearance of the object, increases the credit value associated with the object, and adds the credit value associated with the object to the credit balance of the player.

Abstract: Disclosed herein are systems and methods for a multistatic radar system that is configured to detect airborne objects without the need for a transponder on the aircraft. The multistatic radar can be implemented using preexisting communications infrastructure associated with various networks such as paging networks. The multistatic radar system can be implemented using a plurality of multistatic communications links (e.g., transmitters that are communicatively coupled to a plurality of receivers). The distribution of transmitters and receivers in the network can be based on the RF conditions of the coverage area of the network. The multistatic radar network can produce one or more deterministic waveforms that provide the network with signal diversity needed for accurate detection, localization, and tracking of airborne assets.

Abstract: A method and system for photopolymerization 3D printing is provided. The system includes a processing device, a micro light emitting diode (microLED) array including one or more individually addressable microLED emitters, and a printing component. The processing device is configured to determine one or more printing layers of an object. The microLED array is configured to generate light for each of the one or more printing layers. The printing component is configured to print the one or more printing layers. To generate the light for each of the one or more printing layers, the processing device is further configured to dynamically determine one or more microLED regions in the microLED array, determine one or more region printing parameters for each of the one or more microLED regions; and determine one or more control signals for the one or more individually addressable microLED emitters included in each of the one or more microLED regions based on the one or more region printing parameters.

Abstract: In the embodiments of the present disclosure, additive manufacturing devices and methods are provided. The additive manufacturing device includes a light source, a building device, and a light scattering member. The light source is configured to provide light to cure photocurable resins. The building device includes a resin tank configured to store the photocurable resins. The building device has a building surface on which the photocurable resins are cured. The light scattering member is arranged between the light source and the building surface.

Abstract: Disclosed herein is a terrestrial to air communications network that can be configured to include a spectrum management system that deterministically allocates spectrum to aircraft for use during flight. In one or more examples, a user transmits a flight plan to a spectrum management system that is configured to manage the RF spectrum in a given air space. In one or more examples, and based on the received flight plan, the spectrum management system can allocate an RF spectrum frequency “slot” (i.e., timeslot, subchannel, or resource block) for the aircraft to use during its intended flight. The spectrum management system can take into account available spectrum as well as the predicted network traffic and their spectrum allocations to determine an RF spectrum slot that can provide a stable and continuous communications channel to the aircraft during its flight.

Abstract: Provided is a system for delivering and recording a dose of a medicament to a patient. Also provided is a method of administering a medicament to a patient. Additionally provided is a method of tracking usage of a medicament by a patient through a pen.

Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and second CsgG pore, or a homologue thereof.

Abstract: A method, apparatus, and computer-readable medium for artifact attribution is provided. The method can be performed by a generative system, or generative AI. The method can include storing a proprietary artifact created by a creator and terms of use for usage of the proprietary artifact defined by the creator. The method can also include generating a new artifact based on the proprietary artifact and the user's rights to the proprietary artifact. The method can also include determining an attribution for the new artifact.

Abstract: This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter.

Abstract: The disclosure relates to a nasal cannula comprising a port configured for delivery of a medicament into a flow of a fluid being delivered by the nasal cannula to a user and/or configured for interfacing with a medicament delivery device or an instrument. The disclosure also relates to a nasal cannula comprising an asymmetric profile to reduce an amount of occlusion of one nare of a user to provide access for an instrument to the nare with the nasal cannula in use.