Abstract: Docking stations are configured to retain and position a transcatheter heart valve in a circulatory system. The docking stations can comprise an expandable frame. The docking stations can include an enlarged first end portion having a first outer radial portion with a first major lateral dimension, an enlarged second end portion having a second outer radial portion with a second major lateral dimension, and a narrowed central waist portion having an inner radial portion with a third major lateral dimension smaller than the first and second major lateral dimensions. A retaining portion is at least partially defined by at least one of the first and second end portions, and a valve seat is at least partially defined by the waist portion. The docking station can be configured to adapt a native tricuspid valve to accept a smaller transcatheter heart valve.

Abstract: The present application is directed to agents that bind an epitope specific to a ?3 ?? TCR. Such agents can be, but are not limited to, an antibody or fragment thereof. Also described herein are methods for using the agents, e.g., to expand or selectively expand ?3 ?? T cells. Also described herein are methods of using expanded ?3 ?? T cells for treatment of a subject in need thereof.

Abstract: End launch termination devices are shown and disclosed. In one embodiment, the device includes a housing, a first clamp fixedly attached to the housing, and a second clamp opposed to the first clamp and movably attached to at least one of the first clamp or the housing, the first and second clamps defining a gap therebetween to receive a test substrate. The device additionally includes a conductor received in the cavity and fixedly attached to the housing, a center pin attached to the conductor and extending into the gap, and a rod resistor received in the cavity, attached to the conductor, and extending out of the housing.

Abstract: A computer-implemented method and system for representing and solving at least one of an algebraic problem, a proportions problem, and a linear growth problem. A graphical user interface has a symbolic section and a pictorial section. The symbolic section includes a symbolic representation of the mathematical problem and the pictorial section includes a pictorial representation of the mathematical problem. An input is received from a user. The input is associated with one of the symbolic section and the pictorial section. In response to the input, the other of the symbolic section and the pictorial section is modified such that the symbolic section and the pictorial section track each other. The user solves the mathematical problem by interacting with at least one of the symbolic section and the pictorial section.

Abstract: Expandable docking stations for docking an expandable valve can include a valve seat, one or more sealing portions, and/or one or more retaining portions. The valve seat can include radiopaque markers affixed to a frame or an impermeable member. The radiopaque markers can indicate a deployment location of the valve. The docking stations can be deployed from a catheter including one or more radiopaque markers. Relative positioning of two or more radiopaque markers can provide an indication of the amount of deployment of the docking station.

Abstract: An instructional system and method for representing and solving algebraic problems. A computer-implemented method of representing and solving mathematical problems comprises providing a graphical user interface for displaying an instructional system. The instructional system comprises a primary cog having a plurality of primary cog teeth and a secondary cog having a plurality of secondary cog teeth. The secondary cog is linked to the primary cog such that a rotation of the secondary cog causes a rotation of the primary cog. The method comprises representing a mathematical problem on the graphical user interface using the instructional system. The method includes receiving an input from a user and rotating the secondary cog based on the input to cause the primary cog to also rotate. The mathematical problem is solved when a particular tooth of the plurality of primary cog teeth reaches a predefined location.

Abstract: Aspects of the invention include compositions and methods for treatment of hematological tumors with engineered or non-engineered ??-T cells. In some embodiments, the ??-T cells comprise a chimeric antigen receptor (CAR) construct. The CAR construct can contain an anti-CD20 binding domain or anti-B cell maturation antigen (BCMA) binding domain, a CD8 hinge and transmembrane domain, a costimulatory domain, a CD3 ? signalling domain, a combination thereof, or all thereof. The CAR construct can contain a domain encoding for a secreted common gamma chain cytokine such as a sIL 15 domain.

Abstract: Aspects of the invention include compositions and methods for treatment of solid tumors with engineered or non-engineered ??-T cells. In some embodiments, the ??-T cells comprise a chimeric antigen receptor (CAR) construct. The CAR construct can contain an anti-TryD binding domain, a CD8? hinge and transmembrane domain, a costimulatory domain, a 003? signalling domain, a combination thereof, or all thereof. The CAR construct can contain an anti-GPC3 binding domain, a CD8? hinge and transmembrane domain, a costimulatmy domain, a CD3? signalling domain, a combination thereof, or all thereof. The CAR construct can contain a domain encoding for a secreted common gamma chain cytokine such as a sIL 15 domain.

Abstract: An instructional system and method for representing and solving algebraic problems. A computer-implemented method of representing and solving mathematical problems comprises providing a graphical user interface for displaying an instructional system. The instructional system comprises a primary cog having a plurality of primary cog teeth and a secondary cog having a plurality of secondary cog teeth. The secondary cog is linked to the primary cog such that a rotation of the secondary cog causes a rotation of the primary cog. The method comprises representing a mathematical problem on the graphical user interface using the instructional system. The method includes receiving an input from a user and rotating the secondary cog based on the input to cause the primary cog to also rotate. The mathematical problem is solved when a particular tooth of the plurality of primary cog teeth reaches a predefined location.

Abstract: A surge control system includes a rotor system with at least one compressor section and at least one turbine section operably coupled to a shaft. The surge control system also includes sensors configured to collect sensor data from the rotor system, an electric motor operably coupled to the rotor system, and a controller. The controller is operable to detect surge event from the sensor data, determine an amount of power to apply to the rotor system, and increase the amount of power provided to the rotor system to recover from the surge event.

Abstract: A tile instructional system for presenting a linear growth problem and for allowing the linear growth problem to be solved comprises an input tray having at least a first tile and a second tile. The first tile has a first marking and the second tile has a second marking. Each of the first tile and the second tile is configured to selectively expand in accordance with its respective marking. The system includes a tile bed comprising a plurality of tile slots. Each of the plurality of tile slots is configured to receive a tile. The linear growth problem is solvable by situating in the tile bed at least one of the first tile and the second tile and by causing each tile situated in the tile bed to expand in accordance with its respective marking to fill the tile bed.

Abstract: A liquid flow instructional system for presenting a proportions problem and for allowing the proportions problem to be solved comprises an input container and a plurality of output containers selectively and fluidly coupled to the input container. The system has an adjustable valve having a plurality of configurable regions. Each of the plurality of configurable regions corresponds to one of the plurality of output containers. An activable switch is provided for initiating flow of liquid from the input container to the plurality of output containers in accordance with a user configuration of the plurality of configurable regions. The proportions problem is solvable by filling each of the plurality of output containers to capacity without spillage. The correspondence between the plurality of configurable regions and the plurality of output containers is indicated by a visible indicator.

Abstract: The Coiffure app allows beauty services to be provided world wide through the same system. A user downloads the app, choses his or her service from a variety of available services, such as cosmetology, barbering, manicures/pedicures, massage therapy, spa treatments, and dog grooming. Payment is provided online through the app, including the acceptance of tips. Users can review every licensed beauty professional registered with the app that they have an appointment with. Reviewers are made on a scale of 1 to 5 stars. Both customers and beauty professionals can leave comments. By registering with the Coiffure app, beauty professionals become independent contractors, running their own businesses.

Abstract: A tile instructional system for presenting a linear growth problem and for allowing the linear growth problem to be solved comprises an input tray having at least a first tile and a second tile. The first tile has a first marking and the second tile has a second marking. Each of the first tile and the second tile is configured to selectively expand in accordance with its respective marking. The system includes a tile bed comprising a plurality of tile slots. Each of the plurality of tile slots is configured to receive a tile. The linear growth problem is solvable by situating in the tile bed at least one of the first tile and the second tile and by causing each tile situated in the tile bed to expand in accordance with its respective marking to fill the tile bed.

Abstract: A liquid flow instructional system for presenting a proportions problem and for allowing the proportions problem to be solved comprises an input container and a plurality of output containers selectively and fluidly coupled to the input container. The system has an adjustable valve having a plurality of configurable regions. Each of the plurality of configurable regions corresponds to one of the plurality of output containers. An activable switch is provided for initiating flow of liquid from the input container to the plurality of output containers in accordance with a user configuration of the plurality of configurable regions. The proportions problem is solvable by filling each of the plurality of output containers to capacity without spillage. The correspondence between the plurality of configurable regions and the plurality of output containers is indicated by a visible indicator.

Abstract: A method for adaptively teaching content to a user comprises providing a plurality of teaching topics. The method includes sequentially associating a lead problem and a plurality of secondary problems with each of the plurality of teaching topics. Each of the lead problems and the plurality of secondary problems is an open-ended puzzle having a range of solutions and a difficulty rank. The range of solutions for each of the lead problems and the plurality of secondary problems has an optimal solution and a plurality of secondary solutions. A teaching topic is selected and a corresponding lead problem is presented to a user. User provides answer data via a physical input device having enmeshed gears. The user is provided another secondary problem in the selected teaching topic if the answer data matches one of the secondary solutions. The user is provided another lead problem if the answer data matches the optimal solution.

Abstract: A holder for a smart phone that attaches to a seatbelt by using a scoop to pick up a seatbelt and then distort the seatbelt to secure the holder to the seatbelt. The holder includes a spring-loaded sliding jaw to accommodate insertion of the phone using a single hand. Once the phone is inserted, the smart phone is held in place by the spring-loaded sliding jaw which presses the smart phone against a non-moving jaw. The holder includes features that allow for easy one-handed operation including a landing area for the user's thumb, a flange to aid in removal of the smart phone, a tread to add friction to one of the thumb areas. The sliding jaw is located opposite of the point of the scoop.

Abstract: A method for adaptively teaching content to a user comprises providing a plurality of teaching topics. The method includes sequentially associating a lead problem and a plurality of secondary problems with each of the plurality of teaching topics. Each of the lead problems and the plurality of secondary problems is an open-ended puzzle having a range of solutions and a difficulty rank. The range of solutions for each of the lead problems and the plurality of secondary problems has an optimal solution and a plurality of secondary solutions. A teaching topic is selected and a corresponding lead problem is presented to a user. User provides answer data via a physical input device having enmeshed gears. The user is provided another secondary problem in the selected teaching topic if the answer data matches one of the secondary solutions. The user is provided another lead problem if the answer data matches the optimal solution.

Abstract: An integral vehicle jack assembly is provided for facilitating raising of the ground engaging members of a vehicle off of a supporting surface. The assembly includes a vehicle having a plurality of ground engaging members. A plurality of telescopic supports is coupled to the vehicle. Each support is movable between a deployed position and a retracted position. The deployed position is configured for raising the vehicle such that the ground engaging members are positioned in spaced relationship to a support surface. A control is operationally coupled to the supports for selectively extending and retracting the supports.

Abstract: A visual aim indicator shows players the position of a selected one of a set of aim points during a video game. Each of the set of aim points has a predetermined position. The predetermined positions are within a target region, so that the visual aim indicator shows players the likely destination of their aim. Each aim point is associated with a range of control input values, so that players do not need to provide a precise control input value and can quickly select one of the set of aim points. The sizes of the ranges of control input values associated with the aim points can vary so that a player's aim inputs can be biased towards or away from specific aim points. The visual aim indicator is displayed intermittently during an aiming mode of operation and removed from view when the player completes the aiming mode of operation.