Patents by Inventor Michael Rosconi
Michael Rosconi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12331109Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: GrantFiled: April 19, 2024Date of Patent: June 17, 2025Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
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Publication number: 20250109194Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: ApplicationFiled: December 11, 2024Publication date: April 3, 2025Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Tong ZHANG, Samuel DAVIS, Chia-Yang LIN, Eric SMITH, Erica PYLES, Michael ROSCONI, Nina LIU, Supriya PATEL, Andrew J. MURPHY
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Patent number: 12215148Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: GrantFiled: August 7, 2020Date of Patent: February 4, 2025Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
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Publication number: 20250035532Abstract: The present invention provides methods to identify and quantify empty, partial and full capsids. The capsids can be purified from a crude AAV sample using affinity chromatography and eluted from the solid support. The purified capsids can then be subjected to density gradient equilibrium analytical ultracentrifugation (DGE-AUC) for characterization and quantitation of capsid content.Type: ApplicationFiled: July 26, 2024Publication date: January 30, 2025Inventors: Deepanshu Choudhary, Michael Rosconi, Erica Pyles
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Patent number: 12180272Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: GrantFiled: February 7, 2022Date of Patent: December 31, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
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Publication number: 20240294627Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: ApplicationFiled: April 19, 2024Publication date: September 5, 2024Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
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Publication number: 20240168018Abstract: The present inventions provide methods for detecting and evaluating viruses and virus-like particles using A4F combined with Multi-Angle Light Scattering (MALS) and fluorescent (Flr) detectors. Systems for performing the methods also are provided.Type: ApplicationFiled: November 14, 2023Publication date: May 23, 2024Inventors: Michael Rosconi, Nina Liu, Erica Pyles
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Publication number: 20240167984Abstract: The present inventions provide methods for detecting and determining protein structures and stability, including heteromeric protein complexes, in biological fluids, such as serum and other bodily fluids. Systems for performing the methods also are provided.Type: ApplicationFiled: November 14, 2023Publication date: May 23, 2024Inventors: Michael Rosconi, Nina Liu, Erica Pyles
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Patent number: 11965020Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: GrantFiled: May 17, 2023Date of Patent: April 23, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
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Publication number: 20240060978Abstract: The present invention generally pertains to methods of enriching charge variants of a protein of interest. In particular, the present invention pertains to the use of normal polarity or reverse polarity imaged capillary isoelectric focusing and iterative fractionation to enrich charge variant species of interest.Type: ApplicationFiled: July 14, 2023Publication date: February 22, 2024Inventors: Michael Rosconi, Ramya Rao, Jennifer Nguyen
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Publication number: 20240019443Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.Type: ApplicationFiled: July 6, 2023Publication date: January 18, 2024Inventors: Nina Liu, Michael Rosconi, Erica Pyles
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Publication number: 20230340105Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: ApplicationFiled: May 17, 2023Publication date: October 26, 2023Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
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Patent number: 11754569Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.Type: GrantFiled: August 28, 2019Date of Patent: September 12, 2023Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Nina Liu, Michael Rosconi, Erica Pyles
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Patent number: 11708407Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: GrantFiled: February 7, 2022Date of Patent: July 25, 2023Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
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Publication number: 20220235126Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: ApplicationFiled: February 7, 2022Publication date: July 28, 2022Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
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Publication number: 20220195030Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: ApplicationFiled: February 7, 2022Publication date: June 23, 2022Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
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Publication number: 20210040197Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.Type: ApplicationFiled: August 7, 2020Publication date: February 11, 2021Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
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Publication number: 20200369720Abstract: The present invention provides methods and systems for analyzing the biophysical characteristics of peptides or proteins, such as antibodies, based on enzymatic digestion-assisted imaged capillary electrophoresis (DiCE) to characterize the domain-specific charge variants, preferably within a bispecific antibody. The methods and systems include treating the protein with digestion enzymes to generate components of the protein, reducing or denaturing the components, and separating the components based on their isoelectric points.Type: ApplicationFiled: May 23, 2020Publication date: November 26, 2020Inventors: Sophia Liu, Jennifer NGUYEN, Michael ROSCONI, Erica PYLES
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Publication number: 20200072844Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.Type: ApplicationFiled: August 28, 2019Publication date: March 5, 2020Inventors: Nina Liu, Michael Rosconi, Erica Pyles
