Patents by Inventor Michael Rosconi

Michael Rosconi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigen binding molecule formats
    Patent number: 11965020
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Grant
    Filed: May 17, 2023
    Date of Patent: April 23, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
  • ISOELECTRIC FOCUSING-BASED ENRICHMENT OF CHARGE VARIANT SPECIES
    Publication number: 20240060978
    Abstract: The present invention generally pertains to methods of enriching charge variants of a protein of interest. In particular, the present invention pertains to the use of normal polarity or reverse polarity imaged capillary isoelectric focusing and iterative fractionation to enrich charge variant species of interest.
    Type: Application
    Filed: July 14, 2023
    Publication date: February 22, 2024
    Inventors: Michael Rosconi, Ramya Rao, Jennifer Nguyen
  • METHODS FOR CHARACTERIZING PROTEIN COMPLEXES
    Publication number: 20240019443
    Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.
    Type: Application
    Filed: July 6, 2023
    Publication date: January 18, 2024
    Inventors: Nina Liu, Michael Rosconi, Erica Pyles
  • NOVEL ANTIGEN BINDING MOLECULE FORMATS
    Publication number: 20230340105
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Application
    Filed: May 17, 2023
    Publication date: October 26, 2023
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
  • Methods for characterizing protein complexes
    Patent number: 11754569
    Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: September 12, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Nina Liu, Michael Rosconi, Erica Pyles
  • Antigen binding molecule formats
    Patent number: 11708407
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: July 25, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chia-Yang Lin, Samuel Davis
  • NOVEL ANTIGEN BINDING MOLECULE FORMATS
    Publication number: 20220235126
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Application
    Filed: February 7, 2022
    Publication date: July 28, 2022
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
  • NOVEL ANTIGEN BINDING MOLECULE FORMATS
    Publication number: 20220195030
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Application
    Filed: February 7, 2022
    Publication date: June 23, 2022
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
  • NOVEL ANTIGEN BINDING MOLECULE FORMATS
    Publication number: 20210040197
    Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
    Type: Application
    Filed: August 7, 2020
    Publication date: February 11, 2021
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Tong Zhang, Erica Pyles, Michael Rosconi, Nina Liu, Supriya Patel, Eric Smith, Andrew Murphy, Chiayang Lin, Samuel Davis
  • CHARACTERIZATION OF DOMAIN-SPECIFIC CHARGE VARIANTS OF ANTIBODIES
    Publication number: 20200369720
    Abstract: The present invention provides methods and systems for analyzing the biophysical characteristics of peptides or proteins, such as antibodies, based on enzymatic digestion-assisted imaged capillary electrophoresis (DiCE) to characterize the domain-specific charge variants, preferably within a bispecific antibody. The methods and systems include treating the protein with digestion enzymes to generate components of the protein, reducing or denaturing the components, and separating the components based on their isoelectric points.
    Type: Application
    Filed: May 23, 2020
    Publication date: November 26, 2020
    Inventors: Sophia Liu, Jennifer NGUYEN, Michael ROSCONI, Erica PYLES
  • Methods for Characterizing Protein Complexes
    Publication number: 20200072844
    Abstract: Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein. The disclosed methods can determine the size, heterogeneity, and conformation of protein complexes.
    Type: Application
    Filed: August 28, 2019
    Publication date: March 5, 2020
    Inventors: Nina Liu, Michael Rosconi, Erica Pyles