Patents by Inventor Michael Ross Johnson

Michael Ross Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monothiol mucolytic agents
    Patent number: 10968233
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: April 6, 2021
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William R. Thelin
  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 10526292
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: January 7, 2020
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Prodrugs of dithiol mucolytic agents
    Patent number: 10526283
    Abstract: Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: January 7, 2020
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William R. Thelin
  • Methods of treatment
    Patent number: 10335558
    Abstract: Embodiments disclosed herein are directed to methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: July 2, 2019
    Assignee: PARION SCIENCES, INC.
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • NOVEL MONOTHIOL MUCOLYTIC AGENTS
    Publication number: 20190031679
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Application
    Filed: September 5, 2018
    Publication date: January 31, 2019
    Inventors: Michael Ross JOHNSON, William R. THELIN
  • Monothiol mucolytic agents
    Patent number: 10106551
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 23, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William R. Thelin
  • Inhaled hypertonic saline delivered by a heated nasal cannula
    Patent number: 9987443
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: June 5, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Richard C. Boucher, Michael Ross Johnson
  • DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
    Publication number: 20180111907
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 26, 2018
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS
    Publication number: 20180092915
    Abstract: Provided are methods of treating a variety of disorders of the skin with inhibitors of the epithelial sodium channel (ENaC). The inhibitors are represented by formula (I)-(IV): where R is defined herein.
    Type: Application
    Filed: December 6, 2017
    Publication date: April 5, 2018
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 9878988
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: January 30, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Sodium channel blockers for skin disorders
    Patent number: 9849129
    Abstract: Provided are methods of treating a variety of disorders of the skin with inhibitors of the epithelial sodium channel (ENaC). The inhibitors are represented by formula (I)-(IV): where R is defined herein.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 26, 2017
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • CHEMICALLY AND METABOLICALLY STABLE DIPEPTIDE POSSESSING POTENT SODIUM CHANNEL BLOCKER ACTIVITY
    Publication number: 20170281620
    Abstract: A very stable, selective and renally safe sodium channel blocker represented by the formula: The invention also includes a variety of compositions, combinations and methods of treatment using this inventive sodium channel blocker.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 5, 2017
    Applicant: PARION SCIENCES, INC.
    Inventor: Michael Ross JOHNSON
  • INHALED HYPERTONIC SALINE DELIVERED BY A HEATED NASAL CANNULA
    Publication number: 20170151396
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Application
    Filed: August 8, 2016
    Publication date: June 1, 2017
    Applicant: Parion Sciences, Inc.
    Inventors: Richard C. BOUCHER, Michael Ross JOHNSON
  • Chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity
    Patent number: 9655896
    Abstract: A very stable, selective and renally safe sodium channel blocker represented by the formula: The invention also includes a variety of compositions, combinations and methods of treatment using this inventive sodium channel blocker.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: May 23, 2017
    Assignee: PARION SCIENCES, INC.
    Inventor: Michael Ross Johnson
  • SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS
    Publication number: 20170020870
    Abstract: Provided are methods of treating a variety of disorders of the skin with inhibitors of the epithelial sodium channel (ENaC). The inhibitors are represented by formula (I)-(IV): where R is defined herein.
    Type: Application
    Filed: February 18, 2016
    Publication date: January 26, 2017
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS
    Publication number: 20160318861
    Abstract: Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.
    Type: Application
    Filed: May 2, 2016
    Publication date: November 3, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William R. Thelin
  • Inhaled hypertonic saline delivered by a heated nasal cannula
    Patent number: 9408988
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: August 9, 2016
    Assignee: Parion Sciences, Inc.
    Inventors: Richard C. Boucher, Michael Ross Johnson
  • NOVEL MONOTHIOL MUCOLYTIC AGENTS
    Publication number: 20160222023
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William R. THELIN
  • DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
    Publication number: 20160122306
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: January 5, 2016
    Publication date: May 5, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William Robert THELIN, Richard C. BOUCHER
  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 9260398
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: February 16, 2016
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher