Patents by Inventor Michael Rycyzyn

Michael Rycyzyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-IL-23 Antibodies
    Patent number: 9127058
    Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: September 8, 2015
    Assignee: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Raymond Sweet
  • Human anti-CD27 antibodies, methods and uses
    Patent number: 9102737
    Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 11, 2015
    Assignee: Janssen Biotech, Inc.
    Inventors: John Chen, Johan Fransson, Natalie Fursov, Damon Hamel, Thomas Malia, Galina Obmolova, Tatiana Ort, Michael Rycyzyn, Michael Scully, Raymond Sweet, Alexey Teplyakov, John Wheeler, Juan Carlos Almagro
  • Anti-IL-23 antibodies, compositions, methods and uses
    Patent number: 9096667
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: August 4, 2015
    Assignee: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Raymond Sweet
  • Anti-IL-23 Antibodies, Compositions, Methods and Uses
    Publication number: 20140128576
    Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 8, 2014
    Applicant: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Raymond Sweet
  • Anti-IL-23 Antibodies, Compositions, Methods and Uses
    Publication number: 20140046031
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 13, 2014
    Applicant: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Raymond Sweet
  • Anti-IL-23 antibodies
    Patent number: 8574579
    Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: November 5, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • HUMAN ANTI-CD27 ANTIBODIES, METHODS AND USES
    Publication number: 20130243795
    Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 19, 2013
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: John Chen, Johan Fransson, Natalie Fursov, Damon Hamel, Thomas Malia, Galina Obmolova, Tatiana Ort, Michael Rycyzyn, Michael Scully, Raymond Sweet, Alexey Teplyakov, John Wheeler, Juan Carlos Almagro
  • Anti-IL-23 Antibodies, Compositions, Methods and Uses
    Publication number: 20120308573
    Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: August 16, 2012
    Publication date: December 6, 2012
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • Enhancement of hybridoma fusion efficiencies through cell synchronization
    Patent number: 8216842
    Abstract: The present invention provides methods of enhancing hybridoma fusion efficiencies through cell synchronization of the fusion partners, in order to aid in production of antibodies.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: July 10, 2012
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Jill Giles-Komar, Michael Rycyzyn, Gregory Bannish
  • METHODS FOR GENERATING ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20110319292
    Abstract: A protein variant of IL-23p19 that has conserved residues in positions 93-102, 93-110, and/or 127-137 of SEQ ID NO:1, can be used to generate anti-IL-23p19 antibodies.
    Type: Application
    Filed: September 13, 2011
    Publication date: December 29, 2011
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • Use of B Cell Expansion Agents in Generating Antibodies
    Publication number: 20110200613
    Abstract: A method for efficiently generating antibodies immunizes an animal with a target antigen and a B cell expansion agent, such as an anti-CD40 agonist. The antibodies generated from this method are useful as therapeutic agents, diagnostic agents or research reagents in a variety of diseases and conditions.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Inventors: Cynthia Duchala, Jill M. Giles-Komar, Michael A. Rycyzyn
  • Methods and compositions for modulating somatolactogenic functions
    Patent number: 7902341
    Abstract: Compositions containing cyclophilin B, mutants of cyclophilin B or inhibitors of cyclophilin B and methods of using these compositions to modulate somatolactogenic function are provided.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: March 8, 2011
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Charles Clevenger, Michael A. Rycyzyn
  • Methods and Uses of Anti-IL-23 Antibodies
    Publication number: 20100322863
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: August 31, 2010
    Publication date: December 23, 2010
    Inventors: JACQUELINE BENSON, MARK CUNNINGHAM, CYNTHIA DUCHALA, JILL M. GILES-KOMAR, JINQUAN LUO, MICHAEL A. RYCYZYN, SWEET RAYMOND
  • PROSTAGLANDIN E2 (PGE2) AS AN ADJUVANT IN MONOCLONAL ANTIBODY GENERATION
    Publication number: 20100278875
    Abstract: The present invention provides PGE2 as a novel adjuvant for enhancing the immune response in a host, as well as methods of using PGE2 to enhance B cell response and thereby increasing antibody titer against a given immunogen are also disclosed and antibodies produced by at least one method of the present invention.
    Type: Application
    Filed: September 28, 2007
    Publication date: November 4, 2010
    Inventors: Jill Giles-Komar, Michael A. Rycyzyn
  • Anti-IL-23 antibodies, compositions, methods and uses
    Patent number: 7807414
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: October 5, 2010
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • ENHANCEMENT OF HYBRIDOMA FUSION EFFICIENCIES THROUGH CELL SYNCHRONIZATION
    Publication number: 20100029002
    Abstract: The present invention provides methods of enhancing hybridoma fusion efficiencies through cell synchronization of the fusion partners, in order to aid in production of antibodies.
    Type: Application
    Filed: October 12, 2007
    Publication date: February 4, 2010
    Inventors: Jill Giles-Komar, Michael Rycyzyn, Gregory Bannish
  • Anti-IL-23 Antibodies, Compositions, Methods and Uses
    Publication number: 20090162371
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: February 13, 2009
    Publication date: June 25, 2009
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • Anti-IL-23 antibodies, compositions, methods and uses
    Patent number: 7491391
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: February 17, 2009
    Assignee: Centocor, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • Methods for altering protein production rates
    Patent number: 7479379
    Abstract: Methods for altering the cellular secretion rate of a protein, such as an antibody and the altered cells produced by the method are disclosed. The methods and altered cells are useful for producing high levels of proteins for therapeutic, diagnostic or research purposes.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: January 20, 2009
    Assignee: Centocor, Inc.
    Inventors: Michael Rycyzyn, Gregory Bannish, Jill Giles-Komar
  • Use of B Cell Expansion Agents in Generating Antibodies
    Publication number: 20080286289
    Abstract: A method for efficiently generating antibodies immunizes an animal with a target antigen and a B cell expansion agent, such as an anti-CD40 agonist. The antibodies generated from this method are useful as therapeutic agents, diagnostic agents or research reagents in a variety of diseases and conditions.
    Type: Application
    Filed: October 27, 2006
    Publication date: November 20, 2008
    Inventors: Cynthia Duchala, Jill M. Giles-Komar, Michael A. Rycyzyn