Patents by Inventor Michael S. Ashwood

Michael S. Ashwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making a thrombin inhibitor
    Publication number: 20020103379
    Abstract: The invention is a process for preparing 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide which comprises coupling 1
    Type: Application
    Filed: December 6, 2001
    Publication date: August 1, 2002
    Inventors: Ulf H. Dolling, Ramon Alabaster, Michael S. Ashwood, Ian F. Cottrell, Cameron J. Cowden, Antony J. Davies, David Hands, Debra J. Wallace, Robert D. Wilson
  • Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
    Publication number: 20010029297
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) 1
    Type: Application
    Filed: February 27, 2001
    Publication date: October 11, 2001
    Inventors: Michael S. Ashwood, Ian F. Cottrell, Cameron J. Cowden, Debra J. Wallace
  • Process for synthesizing carbapenem side chain intermediates
    Patent number: 6063931
    Abstract: A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: May 16, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Karel M. J. Brands, John M. Williams, Ulf H. Dolling, Ronald B. Jobson, Antony J. Davies, Ian F. Cottrell, Mark Cameron, Michael S. Ashwood
  • Process for synthesizing carbapenem side chain intermediates
    Patent number: 6060607
    Abstract: A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: May 9, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Karel M. J. Brands, John M. Williams, Ulf H. Dolling, Ronald B. Jobson, Antony J. Davies, Ian F. Cottrell, Mark Cameron, Michael S. Ashwood
  • Process for the preparation of chiral 4-aryloxyazetidinones
    Patent number: 5310899
    Abstract: A process for preparing a single enantiomer of a 4-aryloxyazetidin-2-one derivative in optically pure form comprises reacting a hindered vinyl ester with chlorosulphonyl isocyanate; displacing the hindered acyloxy group with a phenolic derivative containing a protected carboxy group; deprotecting the carboxylate moiety; resolving with a chiral amine; filtering; and regenerating the desired enantiomer by acidification. A method for enriching the product obtained from the acyloxy displacement step in favour of the desired enantiomeric form, by treating with an asymmetric catalyst such as a chiral alkaloid derivative, is provided; as also is a method for racemising the unwanted antipode of the desired 4-aryloxyazetidin-2-one enantiomer. The invention further provides novel enantiomers based on the 4-aryloxyazetidin-2-one ring structure.
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: May 10, 1994
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: Michael S. Ashwood, Brian C. Bishop, Peter G. Houghton, Guy R. Humphrey