Abstract: An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Abstract: An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor, and an elongate shaft having one or more lumens located therein. An articulation joint at the distal end of the endoscope allows the distal end to be oriented by the actuators in the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Abstract: An endoscopic imaging system for examining a patient's body cavity includes an endoscope having a distal end, a proximal end and a number of lumens therein. One or more distal gas ports are disposed at or adjacent the distal end of the endoscope and one or more proximal gas ports are disposed proximal to the distal gas ports. Insufflation gas is delivered to the distal gas ports and withdrawn from the proximal gas ports or vice versa such that a gas bubble is formed in the body cavity and travels with the distal tip of the endoscope.

Abstract: A pump apparatus, which comprises: (a) a tubular portion comprising an electroactive polymer actuator that expands and contracts an inner volume of the tubular portion based upon received control signals; and (b) a control unit electrically coupled to the electroactive polymer actuator and sending control signals to the actuator. The pump apparatus can further include at least one valve that is in fluid communication with the inner volume of the tubular portion. The pump apparatus can be used, for example, as a heart-lung bypass pump apparatus. Also disclosed herein is a method of providing circulatory support for patient.

Abstract: An endoscopic imaging system for examining a patient's body cavity includes an endoscope having a distal end, a proximal end and a number of lumens therein. One or more distal gas ports are disposed at or adjacent the distal end of the endoscope and one or more proximal gas ports are disposed proximal to the distal gas ports. Insufflation gas is delivered to the distal gas ports and withdrawn from the proximal gas ports or vice versa such that a gas bubble is formed in the body cavity and travels with the distal tip of the endoscope.

Abstract: A shaft for a medical device includes an outer sheath and a flexible spiral wrap therein. The flexibility of the spiral wrap is modified by changing the width of the wraps of a spiral, the thickness of the wraps of a spiral, or the gap spacing of the spiral. The spacing between wraps is maintained by attaching the spiral wrap to the cover sheath that surrounds the spiral wrap at two or more locations.

Abstract: A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.

Abstract: Provided are artificial muscle patches, which are adapted to be implanted adjacent a patient's heart, and artificial sphincter cuffs, which are adapted to be implanted around a body lumen, such as the urethra, the anal canal, or the lower esophagus. The devices of the present invention comprise: (a) one or more electroactive polymer actuators; and (b) a control unit for electrically controlling the one or more electroactive polymer actuators to expand or contract the devices.

Abstract: An endoscope apparatus and method of operating the same. The endoscope apparatus comprises an endoscope portion and a control and display unit. The endoscope portion preferably comprises: (i) a sensor disposed at a distal end of the endoscope portion and providing endoscope data; (ii) one or more electronically controlled actuators (e.g., electroactive polymer actuators) controlling the operation of the endoscope portion based on received control signals; (iii) a first wireless transceiver coupled to the sensor and the one or more electronically controlled actuators, transmitting received endoscope data from the sensor and forwarding received control signals to the one or more electronically controlled actuators; and (iv) a portable power source (e.g., a battery) coupled to the sensor, the first wireless transceiver, and the one or more electronically controller actuators.

Abstract: A stenting system for insertion into the lumen of a body duct or vessel for delivering a therapeutic agent to a treatment site on the duct or vessel. The stenting system includes an a tubular stent member having a lumen there through to allow the passage of material, an outer membrane attached to the stent at least a portion of which is porous to the therapeutic agent to allow the agent to pass to the treatment site, an inner membrane attached to the stent which is nonporous to the therapeutic agent to prevent the agent from entering the lumen of the stent, and a chamber located between the inner and outer membranes for holding the therapeutic agent. The therapeutic agent in the chamber may diffuse through the porous portion of the membrane and be deposited directly on the body site.

Abstract: Provided are artificial muscle patches, which are adapted to be implanted adjacent a patient's heart, and artificial sphincter cuffs, which are adapted to be implanted around a body lumen, such as the urethra, the anal canal, or the lower esophagus. The devices of the present invention comprise: (a) one or more electroactive polymer actuators; and (b) a control unit for electrically controlling the one or more electroactive polymer actuators to expand or contract the devices.

Abstract: A steerable endoscopic sheath has a proximal end, a distal end and a working channel lumen disposed therein. A plurality of solid state light emitting devices such as light emitting diodes are positioned near the distal end of the sheath and are selectively energized to illuminate internal body tissues. An imaging device such as a photo diode or CCD array creates an image from light reflected from the tissue. The distal tip of the endoscopic sheath is selectively moveable with a deflection device that is insertable into the sheath. The deflection device includes a tip deflection mechanism that allows a user to move the tip of the deflection device. With the deflection device inserted in the sheath, movement of the distal tip causes a corresponding movement in the distal tip of the sheath. The distal tip of the sheath has a shape retaining mechanism that allows it to retain the shape imparted by the deflection device once the deflection device is removed from the sheath.

Abstract: A control mechanism for automatically steering the distal end of an endoscope into a body cavity. During advancement of the endoscope, the control mechanism directs the distal tip to be moved in a sweep pattern. Images obtained during the sweep pattern are combined and analyzed in order to determine the desired direction of advancement of the endoscope. The distal end of the endoscope is then oriented in the direction of the desired advancement direction. An autoexamination feature can be activated that automatically moves the distal tip in a desired sweep pattern. Images of a body cavity are obtained during each sweep pattern for analysis by the physician.

Abstract: An endoscopic imaging system includes a reusable control cabinet having a number of actuators that control the orientation of a lightweight endoscope that is connectable thereto. The endoscope is used with a single patient and is then disposed. The endoscope includes an illumination mechanism, an image sensor and an elongate shaft having one or more lumens located therein. A polymeric articulation joint at the distal end of the endoscope allows the distal end to be oriented by the control cabinet. The endoscope is coated with a hydrophilic coating that reduces its coefficient of friction and because it is lightweight, requires less force to advance it to a desired location within a patient.

Abstract: An endoscope apparatus and method of operating the same. The endoscope apparatus comprises an endoscope portion and a control and display unit. The endoscope portion preferably comprises: (i) a sensor disposed at a distal end of the endoscope portion and providing endoscope data; (ii) one or more electronically controlled actuators (e.g., electroactive polymer actuators) controlling the operation of the endoscope portion based on received control signals; (iii) a first wireless transceiver coupled to the sensor and the one or more electronically controlled actuators, transmitting received endoscope data from the sensor and forwarding received control signals to the one or more electronically controlled actuators; and (iv) a portable power source (e.g., a battery) coupled to the sensor, the first wireless transceiver, and the one or more electronically controller actuators.

Abstract: A three dimensional cell scaffold is provided including a biocompatible polymer formed from a plurality of fibers configured so as to form a non-woven three dimensional open celled matrix having a predetermined shape, a predetermined pore volume fraction, a predetermined pore shape, and a predetermined pore size, with the matrix having a plurality of connections between the fibers.

Abstract: Provided are artificial muscle patches, which are adapted to be implanted adjacent a patient's heart, and artificial sphincter cuffs, which are adapted to be implanted around a body lumen, such as the urethra, the anal canal, or the lower esophagus. The devices of the present invention comprise: (a) one or more electroactive polymer actuators; and (b) a control unit for electrically controlling the one or more electroactive polymer actuators to expand or contract the devices.

Abstract: A steerable endoscopic sheath has a proximal end, a distal end and a working channel lumen disposed therein. A plurality of solid state light emitting devices such as light emitting diodes are positioned near the distal end of the sheath and are selectively energized to illuminate internal body tissues. An imaging device such as a photo diode or CCD array creates an image from light reflected from the tissue. The distal tip of the endoscopic sheath is selectively moveable with a deflection device that is insertable into the sheath. The deflection device includes a tip deflection mechanism that allows a user to move the tip of the deflection device. With the deflection device inserted in the sheath, movement of the distal tip causes a corresponding movement in the distal tip of the sheath. The distal tip of the sheath has a shape retaining mechanism that allows it to retain the shape imparted by the deflection device once the deflection device is removed from the sheath.

Abstract: A pump apparatus, which comprises: (a) a tubular portion comprising an electroactive polymer actuator that expands and contracts an inner volume of the tubular portion based upon received control signals; and (b) a control unit electrically coupled to the electroactive polymer actuator and sending control signals to the actuator. The pump apparatus can further include at least one valve that is in fluid communication with the inner volume of the tubular portion. The pump apparatus can be used, for example, as a heart-lung bypass pump apparatus. Also disclosed herein is a method of providing circulatory support for a patent.

Abstract: The present invention is directed to a drug delivery pump apparatus, which comprises: (a) an expandable and contractible enclosure having an interior volume that defines a medication reservoir; (b) one or more electroactive polymer actuators; (c) a medication outlet port providing fluid communication between the interior volume of the contractible and expandable enclosure and an exterior of the delivery pump apparatus; and (d) a control unit electrically coupled to the one or more actuators and sending control signals to the same. The one or more electroactive polymer actuators act to reduce the interior volume of the contractible and expandable enclosure based upon the received control signals. The present invention is also directed to a method of delivering a liquid therapeutic agent to a patient.