Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A hand hygiene monitoring system is provided. The system includes a wearable tag device coupled to a user, and a reader device communicably coupled to the wearable tag device. The reader device is configured to detect a presence of the wearable tag device by receiving a first frequency message comprising a user identifier from the wearable tag device. The reader device is further configured to transmit a second frequency message to the wearable tag device requesting event log data. The second frequency has a higher frequency than the first frequency. The reader device is further configured to receive an event log data message from the wearable tag device at the second frequency, and to determine whether the wearable tag device has logged a wash station encounter within a configurable time period based on the event log data message.

Abstract: A hand hygiene monitoring system is provided. The system includes a wearable tag device coupled to a user, and a reader device communicably coupled to the wearable tag device. The reader device is configured to detect a presence of the wearable tag device by receiving a first frequency message comprising a user identifier from the wearable tag device. The reader device is further configured to transmit a second frequency message to the wearable tag device requesting event log data. The second frequency has a higher frequency than the first frequency. The reader device is further configured to receive an event log data message from the wearable tag device at the second frequency, and to determine whether the wearable tag device has logged a wash station encounter within a configurable time period based on the event log data message.

Abstract: A hand hygiene monitoring system is provided. The hand hygiene monitoring system includes a wearable device coupled to a user, and a beacon associated with a hand hygiene station and configured to communicate with the wearable device. The wearable device is configured to initiate monitoring for a hand hygiene operation based on determining the wearable device is located within a predetermined distance from the beacon, and monitor hand hygiene parameters associated with the hand hygiene operation. The hand hygiene parameters are associated with a quality level of the hand hygiene operation performed by the user.

Abstract: Identifying marks are often used for authentication and tracking purposes with various types of articles, but they can sometimes be subject to replication or removal by an outside entity, such as a person or group having malicious intent. Carbon nanotubes and other carbon nanomaterials can be used to form identifying marks that are not visible to the naked eye, thereby making the marks more difficult for an outside entity to tamper with. Various articles can include an identifying mark that is not visible to the naked eye, the identifying mark containing a nanomaterial that includes a plurality of carbon nanotubes with a registered distribution of chiralities. The registered distribution of chiralities can be further tailored to increase the level of security provided by the mark.

Abstract: Identifying marks are often used for authentication and tracking purposes with various types of articles, but they can sometimes be subject to replication or removal by an outside entity, such as a person or group having malicious intent. Carbon nanotubes and other carbon nanomaterials can be used to form identifying marks that are not visible to the naked eye, thereby making the marks more difficult for an outside entity to tamper with. Various articles can include an identifying mark that is not visible to the naked eye, the identifying mark containing a nanomaterial that includes a plurality of carbon nanotubes with a registered distribution of chiralities. The registered distribution of chiralities can be further tailored to increase the level of security provided by the mark.

Abstract: A vehicle includes a chassis and a plurality of wheel assemblies articulated with the chassis, each of the plurality of wheel assemblies comprising a rotatable wheel spaced away from the chassis. A vehicle includes a chassis and an articulated suspension system mounted to the chassis. A method includes comprising articulating at least one of a plurality of wheel assemblies with a chassis, each of the wheel assemblies including a rotatable wheel spaced apart from the chassis. A vehicle includes a chassis and articulatable means for rolling the chassis along a path.

Abstract: A ground vehicle and a method for articulating a payload module for mobility assist are disclosed. The ground vehicle comprises a chassis; and a payload module capable of articulating relative to the chassis to assist the mobility of the ground vehicle. The method comprises articulating a payload module relative to a chassis.

Abstract: A hub drive includes an in-hub motor and a shifting in-hub transmission coupled with the motor. A hub drive wheel assembly includes a wheel comprising a hub, an in-hub motor, and a shifting in-hub transmission having an input attached to the motor and an output attached to the wheel. A vehicle includes a chassis, a wheel comprising a hub, an in-hub motor, and a shifting in-hub transmission having an input attached to the motor and an output attached to the wheel for rotating the wheel with respect to the chassis. A method includes providing a shifting transmission and a motor coupled with the transmission in a hub of a wheel, providing electrical power to the motor, and rotating the motor with the electrical power. The method further includes rotating the transmission with the motor and rotating the wheel with the transmission.

Abstract: A ground vehicle and a method for articulating a payload module for mobility assist are disclosed. The ground vehicle comprises a chassis; and a payload module capable of articulating relative to the chassis to assist the mobility of the ground vehicle. The method comprises articulating a payload module relative to a chassis.

Abstract: An articulated vehicle suspension system shoulder joint is disclosed. A vehicle includes a plurality of wheel assemblies; a plurality of rotating shoulder joints, each wheel assembly being mounted to a respective one of the shoulder joints and rotatable in a plane by the respective shoulder joint; and a chassis to which the shoulder joints are mounted. The shoulder joint for use in a vehicle suspension system includes a housing to which a wheel assembly may be attached for in-plane rotation; a drive; and a transmission engaged with the housing and the drive to reduce the speed of the drive motor as it drives the housing.

Abstract: A ground vehicle and a method for articulating a payload module for mobility assist are disclosed. The ground vehicle comprises a chassis; and a payload module capable of articulating relative to the chassis to assist the mobility of the ground vehicle. The method comprises articulating a payload module relative to a chassis.

Abstract: An articulated vehicle suspension system shoulder joint is disclosed. A vehicle includes a plurality of wheel assemblies; a plurality of rotating shoulder joints, each wheel assembly being mounted to a respective one of the shoulder joints and rotatable in a plane by the respective shoulder joint; and a chassis to which the shoulder joints are mounted. The shoulder joint for use in a vehicle suspension system includes a housing to which a wheel assembly may be attached for in-plane rotation; a drive; and a transmission engaged with the housing and the drive to reduce the speed of the drive motor as it drives the housing.

Abstract: A hub drive includes an in-hub motor and a shifting in-hub transmission coupled with the motor. A hub drive wheel assembly includes a wheel comprising a hub, an in-hub motor, and a shifting in-hub transmission having an input attached to the motor and an output attached to the wheel. A vehicle includes a chassis, a wheel comprising a hub, an in-hub motor, and a shifting in-hub transmission having an input attached to the motor and an output attached to the wheel for rotating the wheel with respect to the chassis. A method includes providing a shifting transmission and a motor coupled with the transmission in a hub of a wheel, providing electrical power to the motor, and rotating the motor with the electrical power. The method further includes rotating the transmission with the motor and rotating the wheel with the transmission.

Abstract: A virtual sensor mast for a ground vehicle and a method for operating a ground vehicle using a virtual sensor mast are disclosed. The virtual sensor mast includes an unmanned airborne vehicle capable of lifting itself from the ground vehicle upon deployment therefrom; a sensor suite mounted to the unmanned airborne vehicle; and a tether between the unmanned airborne vehicle and the ground vehicle over which the sensor suite is capable of communicating sensed data upon deployment. The method includes elevating a tethered unmanned airborne vehicle from the ground vehicle to a predetermined height; sensing environmental conditions surrounding the ground vehicle; and terminating the deployment.

Abstract: A method of controlling traction in a vehicle having an articulated suspension includes determining a performance characteristic of the vehicle; determining a performance characteristic of at least one of a plurality of wheel assemblies of the articulated suspension; comparing the performance characteristic of the vehicle and the performance characteristic of the at least one of the plurality of wheel assemblies; and altering the performance of the vehicle based upon the comparison to affect the vehicle's traction. A method of controlling traction in a vehicle having an articulated suspension includes determining a load on each of a plurality of wheel assemblies of the articulated suspension and adjusting the articulated suspension such that each of the loads is within a predetermined range.

Abstract: A method of controlling stability of a vehicle having an articulated suspension includes determining at least one dynamic property of the vehicle and manipulating the articulated suspension based on the at least one dynamic property to affect the stability of the vehicle. A method of controlling stability of a vehicle having an articulated suspension includes determining a damping scenario and adjusting damping levels of a plurality of active dampers of the articulated suspension. A method of controlling stability of a vehicle having an articulated suspension includes determining a load on each of a plurality of wheel assemblies of the articulated suspension and manipulating at least one component of the vehicle to affect at least one of a center of gravity of the vehicle and the vehicle's stability limits.

Abstract: A ground vehicle and a method for articulating a payload module for mobility assist are disclosed. The ground vehicle comprises a chassis; and a payload module capable of articulating relative to the chassis to assist the mobility of the ground vehicle. The method comprises articulating a payload module relative to a chassis.

Abstract: An articulated vehicle suspension system shoulder joint is disclosed. A vehicle includes a plurality of wheel assemblies; a plurality of rotating shoulder joints, each wheel assembly being mounted to a respective one of the shoulder joints and rotatable in a plane by the respective shoulder joint; and a chassis to which the shoulder joints are mounted. The shoulder joint for use in a vehicle suspension system includes a housing to which a wheel assembly may be attached for in-plane rotation; a drive; and a transmission engaged with the housing and the drive to reduce the speed of the drive motor as it drives the housing.

Abstract: A hub drive includes an in-hub motor and a shifting in-hub transmission coupled with the motor. A hub drive wheel assembly includes a wheel comprising a hub, an in-hub motor, and a shifting in-hub transmission having an input attached to the motor and an output attached to the wheel. A vehicle includes a chassis, a wheel comprising a hub, an in-hub motor, and a shifting in-hub transmission having an input attached to the motor and an output attached to the wheel for rotating the wheel with respect to the chassis. A method includes providing a shifting transmission and a motor coupled with the transmission in a hub of a wheel, providing electrical power to the motor, and rotating the motor with the electrical power. The method further includes rotating the transmission with the motor and rotating the wheel with the transmission.