Abstract: An example operation may include one or more of changing a status of a current blockchain to a closed and retired status based on expiration of a limited time window, creating a genesis block associated with a new blockchain, storing a world state of the current blockchain in the genesis block, creating one or more smart contracts, storing the one or more smart contracts on the new blockchain, and initiating an open stage on the new blockchain, and the open stage permits one or more potential blockchain transactions to be written to the new blockchain.

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A system includes a plurality of thermostats corresponding to a plurality of HVAC systems that serve a plurality of spaces and a computing system communicable with the plurality of thermostats via a network. The computing system is configured to, for each space of the plurality of spaces, obtain a set of training data relating to thermal behavior of the space, identify a model of thermal behavior of the space based on the set of training data, perform a model predictive control process using the model of thermal behavior of the space to obtain a temperature setpoint for the space, and provide the temperature setpoint to the thermostat corresponding to the HVAC system serving the space. The plurality of thermostats are configured to control the plurality of HVAC systems in accordance with the temperature setpoints.

Abstract: A strut and method for assembling a strut. The strut comprises two strut members attachable by a threading mechanism or the like. A first strut member is screwed into the second strut member. A pin hole is formed at the seam between the strut members and a pin is inserted into the pin hole. A locking ring is formed around the pin hole that includes an angular lip adjacent to the hole. The locking of the pin is accomplished, by swaging the angular lip into the hole and over the pin to lock the pin in the pin hole. The purpose of the pin is to ensure the joint does not untwist during operation.

Abstract: A gas turbine engine includes a combustor having a dual-wall impingement convention effusion combustor tile assembly. The dual-wall tile assembly provides a cooling air flow channel and attachments for securing the tile to the cold skin liner of the combustor. Cooling is more efficient in part due to the dual wall construction and in part due to reduced parasitic leakage, and the design is less sensitive to attachment features which operate at lower temperatures.

Abstract: A gas turbine engine includes a combustor having a dual-wall impingement convention effusion combustor tile assembly. The dual-wall tile assembly provides a cooling air flow channel and attachments for securing the tile to the cold skin liner of the combustor. Cooling is more efficient in part due to the dual wall construction and in part due to reduced parasitic leakage, and the design is less sensitive to attachment features which operate at lower temperatures.

Abstract: A flexible bellows assembly is disclosed for sealing an engine igniter for use with an engine. The bellows assembly includes a mounting arrangement that is operable to be secured to a combustor diffuser instead of the combustor liner. The bellows has a component that impinges upon a surface of the combustor liner so as to form a sealed chamber between a metal diffuser and a ceramic combustion liner. An igniter passes through the sealed chamber and provides ignition to the combustor.

Abstract: A cooling system for use in a mass storage chassis assembly is provided. The cooling system in one example includes a frame including one or more fan bays for receiving one or more fan units, one or more fan bay connectors located in the one or more fan bays and configured to couple to and provide electrical power to the one or more fan units, a plurality of retainer devices positioned in each fan bay, with the plurality of retainer devices configured to receive and hold a plurality of projections extending from each fan unit, and the one or more fan units configured to be installed to the one or more fan bays, with each fan unit including a fan connector that couples to the corresponding fan bay connector.

Abstract: A cooling system for use in a mass storage chassis assembly is provided. The cooling system in one example includes a frame including one or more fan bays for receiving one or more fan units, one or more fan bay connectors located in the one or more fan bays and configured to couple to and provide electrical power to the one or more fan units, a plurality of retainer devices positioned in each fan bay, with the plurality of retainer devices configured to receive and hold a plurality of projections extending from each fan unit, and the one or more fan units configured to be installed to the one or more fan bays, with each fan unit including a fan connector that couples to the corresponding fan bay connector.

Abstract: A flexible bellows assembly is disclosed for sealing an engine igniter for use with an engine. The bellows assembly includes a mounting arrangement that is operable to be secured to a combustor diffuser instead of the combustor liner. The bellows has a component that impinges upon a surface of the combustor liner so as to form a sealed chamber between a metal diffuser and a ceramic combustion liner. An igniter passes through the sealed chamber and provides ignition to the combustor.

Abstract: A gas turbine engine includes a combustor having a dual-wall impingement convention effusion combustor tile assembly. The dual-wall tile assembly provides a cooling air flow channel and attachments for securing the tile to the cold skin liner of the combustor. Cooling is more efficient in part due to the dual wall construction and in part due to reduced parasitic leakage, and the design is less sensitive to attachment features which operate at lower temperatures.

Abstract: A method of biochemical processing may, in certain embodiments, involve the steps of use of a consumable biochemical process element and a consumable biochemical process alterable information memory element associated therewith, such as a substance withdrawal consumable biochemical process alterable information memory element, that may be queried and at least some of whose information may be changed as a result of actions conducted during processing of a biochemical test sequence. Accordingly, advantages relative to knowing how much of a consumable biochemical process element has been used, and how much may be available during a biochemical test sequence, may be achieved.

Abstract: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.

Abstract: A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minute to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.

Abstract: A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract: Positioning apparatus to place a reference point at selected locations in a plane. Two carriages are independently mounted to a carriage rail. The rail bears location references and the carriage carry sensors responsive to them to learn their positions along the carriage rail. Guideways and guide rails are mounted in pairs to a respective carriage and to an interface member bearing the reference point. They form an angle between them such that the interface member moves in the plane as a function of the locations of the carriages along the axis and relative to each other. Drivers drive the carriages in response to commands related to the location of the carriages.