Abstract: Systems, devices and methods that improve the placement of orthopedic components and/or instrumentation during surgery. In one particular embodiment, the systems, devices and methods provide drill guides that remove the need for three-handed placement of implant components and reduce complications of implant and fixation member placement. Also disclosed is a sheath with a rounded tip that engages a spherical recess of a patient matched cutting block to reduce the ability of the first fixation pin to communicate unintentional moment/torque to the patient matched instrument through a new articulation between the pin and the guide. Once the first fixation pin has been placed to secure the patient matched instrument to the bone, the effect of subsequent pins is greatly diminished. Subsequent pins may or may not also be decoupled rotationally.