Abstract: In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. The proximal end of the infusion lumen may be in communication with an infusion pump. In some embodiments, the device inhibits cross contamination between a first fluid in the aspiration lumen and a second fluid in the infusion lumen.

Abstract: A method of treating a subject which may be a human suffering from epilepsy which may be a form of epilepsy resistant to treatment and particular patients which are resistant to treatment with oral medication. The method involves positioning a catheter device in the subject's brain and infusing a liquid formulation of a drug into a portion of the subject's brain through an infusion lumen at a rate of 5, 4, 3, 2, or 1 ml or less per day ±50%. The infusion may be constant and corrected by aspirating fluid from the patient's brain and testing the aspirated fluid for drug concentration. The rate of infusion by the formulation and the concentration of drug may be adjusted based on patient responsiveness.

Abstract: In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. In some embodiments, the container may include a barrier positioned between a proximal opening of the aspiration lumen and at least a portion of the infusion lumen adjacent to and/or associated with the container. The barrier may inhibit penetration of a surgical instrument.

Abstract: In some embodiments, a method may include treating brain cancer sensitive to cytotoxic effect. The method may include intraventricularly administering to a subject via a subject's cerebrospinal fluid an effective amount of a pharmaceutical formulation. The pharmaceutical formulation may include at least one chemical compound. In some embodiments, the pharmaceutical formulation may include at least one aqueous diluent. The at least one chemical compound may include a molecular weight of between about 400 MW and about 10,0000 MW. The at least one chemical compound may include protein binding of greater than 30% and greater than 70 Angstroms in cross sectional area. In some embodiments, the at least one chemical compound includes Irinotecan, SN-38, and/or a related derivative thereof. In some embodiments, the method may include ameliorating and/or inhibiting brain cancer in the subject using the pharmaceutical formulation.

Abstract: A method of treating a subject which may be a human suffering from epilepsy which may be a form of epilepsy resistant to treatment and particular patients which are resistant to treatment with oral medication. The method involves positioning a catheter device in the subject's brain and infusing a liquid formulation of a drug into a portion of the subject's brain through an infusion lumen at a rate of 5, 4, 3, 2, or 1 ml or less per day ±50%. The infusion may be constant and corrected by aspirating fluid from the patient's brain and testing the aspirated fluid for drug concentration. The rate of infusion by the formulation and the concentration of drug may be adjusted based on patient responsiveness.

Abstract: The invention provides for ensuring proper transfer of a fluid to a medical device using a syringe by determining a position of a distal end of the needle relative to the medical device and/or a subject using a sensor. If the position of the distal end of the needle relative to a desired point of injection on a medical device and/or the subject is determined to be within predefined parameters transfer of a content of the syringe to the medical device takes place or may be inhibited by a lockout system.

Abstract: In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. The proximal end of the infusion lumen may be in communication with an infusion pump. In some embodiments, the device inhibits cross contamination between a first fluid in the aspiration lumen and a second fluid in the infusion lumen.

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract: Methods of derating a nonlinear ultrasound field and associated systems are disclosed herein. A method of derating a nonlinear ultrasound field in accordance with an embodiment of the present technology can include, for example, calibrating an ultrasound source to a first source voltage (Vw) and generating a nonlinear acoustic wave from the ultrasound source into water. The method can further include measuring a focal waveform of the nonlinear acoustic wave and determining a second source voltage (Vt) of the ultrasound source that generates the same focal waveform in tissue.

Abstract: A system and method for managing captured network traffic data is provided. The invention comprises a plurality of capture agents, each being configured to capture the network traffic associated with one or more applications. Each application is associated with one or more capture agents according to an application profile that is stored and maintained in a capture server. When analysis of an application's network traffic is required, the capture server contacts the corresponding capture agents according to the application profile. The capture server then effects the identification and archiving of the network traffic that corresponds to a user-defined capture condition. A database at the capture server maintains a record that associates the corresponding network traffic with the user-defined capture condition such that the corresponding network traffic can later be retrieved and analyzed using an analysis engine.

Abstract: A system and method for managing captured network traffic data is provided. The invention comprises a plurality of capture agents, each being configured to capture the network traffic associated with one or more applications. Each application is associated with one or more capture agents according to an application profile that is stored and maintained in a capture server. When analysis of an application's network traffic is required, the capture server contacts the corresponding capture agents according to the application profile. The capture server then effects the identification and archiving of the network traffic that corresponds to a user-defined capture condition. A database at the capture server maintains a record that associates the corresponding network traffic with the user-defined capture condition such that the corresponding network traffic can later be retrieved and analyzed using an analysis engine.

Abstract: Methods of derating a nonlinear ultrasound field and associated systems are disclosed herein. A method of derating a nonlinear ultrasound field in accordance with an embodiment of the present technology can include, for example, calibrating an ultrasound source to a first source voltage (Vw) and generating a nonlinear acoustic wave from the ultrasound source into water. The method can further include measuring a focal waveform of the nonlinear acoustic wave and determining a second source voltage (Vt) of the ultrasound source that generates the same focal waveform in tissue.

Abstract: A system and method for managing captured network traffic data is provided. The invention comprises a plurality of capture agents, each being configured to capture the network traffic associated with one or more applications. Each application is associated with one or more capture agents according to an application profile that is stored and maintained in a capture server. When analysis of an application's network traffic is required, the capture server contacts the corresponding capture agents according to the application profile. The capture server then effects the identification and archiving of the network traffic that corresponds to a user-defined capture condition. A database at the capture server maintains a record that associates the corresponding network traffic with the user-defined capture condition such that the corresponding network traffic can later be retrieved and analyzed using an analysis engine.

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract: A graphic user interface facilitates the hierarchical analysis of timing parameters related to network-based applications. At the top level of the hierarchy, the user is presented a summary of the delays incurred while running an application, or while simulating the running of an application, organized by delay categories, including processing delays at each node, as well as propagation delays at each link between nodes. The interface enables a user to “drill down” into lower levels of the timing information hierarchy by ‘clicking’ on currently displayed information. The information is presented in a form most appropriate to the level of analysis. The presentation forms include, for example, pie-charts, multi-variable timing diagrams (in both absolute and relative forms), data exchange charts, and so on, and ‘zoom’ capabilities are provided as appropriate to the particular display form.