Abstract: Provided herein is A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

Abstract: The invention provides hyperspectral imaging-based methods that enable effective, efficient and non-invasive detection and characterization of thermal and ionizing radiation exposure in tissue. The methods allow for complete visualization and quantification of oxygenation and perfusion changes in thermal burn or ionizing radiation impacted skin and enables rapid identification of individuals exposed to such exposures and allows early prediction of extent of injury in normal tissue after exposure.

Abstract: The invention is based on the discovery of hyperspectral imaging-based methods that enable effective, efficient and non-invasive detection and characterization of ionizing radiation exposure in tissue. Methods of the invention allow for complete visualization and quantification of oxygenation and perfusion changes in irradiated skin. The invention enables rapid identification of individuals exposed to ionizing radiation after a radiological attack or accident. Methods of the invention can offer quantitative metrics to identify people exposed to higher doses of ionizing radiation well before the appearance of any dermal injury and permit appropriate triage to healthcare facilities.