Patents by Inventor Michael S. Dappen

Michael S. Dappen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of Polymer Conjugates of Therapeutic, Agricultural, and Food Additive Compounds
    Publication number: 20140073788
    Abstract: Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 13, 2014
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Andrei W. Konradi, Jenifer L. Smith, Michael S. Dappen, Christopher M. Semko
  • Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    Patent number: 8569426
    Abstract: Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: October 29, 2013
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Andrei W. Konradi, Jenifer L. Smith, Michael S. Dappen, Christopher M. Semko
  • Preparation of Polymer Conjugates of Therapeutic, Agricultural, and Food Additive Compounds
    Publication number: 20130018187
    Abstract: Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.
    Type: Application
    Filed: September 18, 2012
    Publication date: January 17, 2013
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Andrei W. Konradi, Jenifer L. Smith, Michael S. Dappen, Christopher M. Semko
  • N-sulfonamido polycyclic pyrazolyl compounds
    Patent number: 8283358
    Abstract: The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: October 9, 2012
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Andrei W. Konradi, Xiaocong Michael Ye, Simeon Bowers, Albert W. Garofalo, Danielle L. Aubele, Darren Dressen, Raymond Ng, Gary Probst, Christopher M. Semko, Minghua Sun, Anh P. Truong, Michael S. Dappen
  • Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    Patent number: 8268935
    Abstract: Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: September 18, 2012
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Andrei W. Konradi, Jenifer L. Smith, Michael S. Dappen, Christopher M. Semko
  • N-Substituted Benzene Sulfonamides
    Publication number: 20110212920
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Application
    Filed: May 9, 2011
    Publication date: September 1, 2011
    Inventors: Martin Neitzel, Michael S. Dappen, Jennifer Marugg
  • N-substituted benzene sulfonamides
    Patent number: 7939657
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: May 10, 2011
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Martin Neitzel, Michael S. Dappen, Jennifer Marugg
  • Process for the Production of Fused, Tricyclic Sulfonamides
    Publication number: 20110034691
    Abstract: The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5-(aryl-sulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention.
    Type: Application
    Filed: March 24, 2010
    Publication date: February 10, 2011
    Inventors: Michael S. Dappen, Jacek J. Jagodzinski, Lee H. Latimer, Jing Wu, Jollie Duaine Godfrey, JR., Robert Michael Matunas, Thomas W. Drabb, Gary Probst
  • N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS
    Publication number: 20100081680
    Abstract: The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.
    Type: Application
    Filed: September 4, 2009
    Publication date: April 1, 2010
    Inventors: Andrei W. Konradi, Xiaocong Michael Ye, Simeon Bowers, Albert W. Garofalo, Danielle L. Aubele, Darren Dressen, Raymond Ng, Gary Probst, Christopher M. Semko, Minghua Sun, Anh P. Truong, Michael S. Dappen
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Patent number: 7635775
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: December 22, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
    Patent number: 7288526
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: October 30, 2007
    Assignees: Elan Pharmaceuticals, Inc., Wyeth
    Inventors: Eugene D. Thorsett, Christopher M. Semko, Michael A. Pleiss, Louis John Lombardo, Francine S. Grant, Darren B. Dressen, Michael S. Dappen
  • N-substituted benzene sulfonamides
    Patent number: 7208488
    Abstract: Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. In Formula (I), R1, R2, R3, R4, R3?, R10 and R11 are as described herein. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: April 24, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Martin Neitzel, Michael S. Dappen, Jennifer Marugg
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Patent number: 7183281
    Abstract: Disclosed are sulfonylquinoxalone derivatives of the general formula: These compounds are useful as bradykinin antagonists.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: February 27, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • Compounds which inhibit leukocyte adhesion mediated by VLA-4
    Patent number: 7166580
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: January 23, 2007
    Assignees: Elan Pharmaceuticals, Inc., Wyeth
    Inventors: Michael S. Dappen, Darren B. Dressen, Francine S. Grant, Michael A. Pleiss, Cynthia Y. Robinson, Dimitrios Sarantakis, Eugene D. Thorsett
  • Sulfonylquinoxalone derivatives as bradykinin antagonists
    Patent number: 7056937
    Abstract: Disclosed are 1-sulfonylquioxalone acetamides and derivatives thereof. The compounds are exemplified by compounds of the formula: Such compounds, derivatives and related compounds are useful as bradykinin antagonists.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: June 6, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Ryan Holcomb, Michael A. Pleiss, Eugene D. Thorsett, Michael Ye, Jon E. Hawkinson
  • Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists
    Publication number: 20040147520
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Application
    Filed: May 2, 2003
    Publication date: July 29, 2004
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • Sulfonylquinoxalone acetamide derivatives as bradykinin antagonists
    Publication number: 20040147519
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Application
    Filed: May 2, 2003
    Publication date: July 29, 2004
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Ryan Holcomb, Michael A. Pleiss, Eugene D. Thorsett, Michael Ye, Jon E. Hawkinson
  • Compounds which inhibit leukocyte adhesion mediated by VLA-4
    Publication number: 20030166575
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Application
    Filed: October 7, 2002
    Publication date: September 4, 2003
    Inventors: Michael S. Dappen, Darren B. Dressen, Francine S. Grant, Michael A. Pleiss, Cynthia Y. Robinson, Dimitrios Sarantakis, Eugene D. Thorsett
  • Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
    Patent number: 6586602
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, wherein the disease may be, for example, asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: July 1, 2003
    Inventors: Eugene D. Thorsett, Christopher M. Semko, Michael A. Pleiss, Louis John Lombardo, Andrei W. Konradi, Francine S. Grant, Darren B. Dressen, Michael S. Dappen
  • Compounds which inhibit leukocyte adhesion mediated by VLA-4
    Patent number: 6559127
    Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: May 6, 2003
    Assignees: Athena Neurosciences, Inc., American Home Products Corp.
    Inventors: Michael S. Dappen, Darren B. Dressen, Francine S. Grant, Michael A. Pleiss, Cynthia Y. Robinson, Dimitrios Sarantakis, Eugene D. Thorsett