Patents by Inventor Michael S. Fleming

Michael S. Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoconjugate formulations
    Patent number: 9114179
    Abstract: The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: August 25, 2015
    Assignee: ImmunoGen, Inc.
    Inventors: Wei Zhang, Michael S. Fleming, Godfrey Amphlett, Hung-wei Chih, Elizabeth Bartlett
  • POLYMERIC MICROSPHERES
    Publication number: 20090232901
    Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.
    Type: Application
    Filed: October 30, 2008
    Publication date: September 17, 2009
    Applicant: TUFTS UNIVERSITY
    Inventors: David R. Walt, Tarun K. Mandal, Michael S. Fleming
  • Polymeric microspheres
    Publication number: 20040219360
    Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.
    Type: Application
    Filed: April 12, 2004
    Publication date: November 4, 2004
    Inventors: David R. Walt, Tarun K. Mandal, Michael S. Fleming
  • Polymeric microspheres
    Patent number: 6720007
    Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: April 13, 2004
    Assignee: Tufts University
    Inventors: David R. Walt, Tarun K. Mandal, Michael S. Fleming
  • Polymeric microspheres
    Publication number: 20020172716
    Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.
    Type: Application
    Filed: October 25, 2001
    Publication date: November 21, 2002
    Inventors: David R. Walt, Tarun K. Mandal, Michael S. Fleming