Abstract: This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules.

Abstract: This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules.

Abstract: This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules.

Abstract: A miniaturized Surface Plasmon Resonance (SPR) imaging system (20) is provided, which includes a light source (21), a sensor substrate (26c) arranged to receive light at an incident angle from the light source, and a detector (31) for detecting an image from the sensor substrate. The system further includes a folded light path structure (23) arranged between the light source and the detector. The folded light path structure includes the sensor substrate (26c), and is configured so as to receive the light from the light source, to redirect the received light to be incident on the sensor substrate (26c) at the incident angle (first redirection), and to further redirect the light reflected from the sensor substrate (26c) toward the detector (second redirection). The folded light path structure allows for a minimal instrumentation footprint, which in turn allows for the construction of a miniaturized, hand-portable SPR imaging system.

Abstract: This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules.

Abstract: The register file of a processor includes embedded operand queues. The configuration of the register file into registers and operand queues is defined dynamically by a computer program. The programmer determines the trade-off between the number and size of the operand queue(s) versus the number of registers used for the program. The programmer partitions a portion of the registers into one or more operand queues. A given queue occupies a consecutive set of registers, although multiple queues need not occupy consecutive registers. An additional address bit is included to distinguish operand queue addresses from register addresses. Queue state logic tracks status information for each queue, including a header pointer, tail pointer, start address, end address and number of vacancies value. The program sets the locations and depth of a given operand queue within the register file.