Patents by Inventor Michael S. Hershfield

Michael S. Hershfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEG-Urate Oxidase Conjugates and Use Thereof
    Publication number: 20100323422
    Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
    Type: Application
    Filed: April 28, 2010
    Publication date: December 23, 2010
    Inventors: L. David WILLIAMS, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
  • PEG-urate oxidase conjugates and use thereof
    Patent number: 7723089
    Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: May 25, 2010
    Assignees: Mountain View Pharmaceuticals, Inc., Duke University
    Inventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
  • PEG-urate oxidase conjugates and use thereof
    Publication number: 20030166249
    Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
    Type: Application
    Filed: April 19, 2001
    Publication date: September 4, 2003
    Inventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman
  • PEG-urate oxidase conjugates and use thereof
    Patent number: 6576235
    Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: June 10, 2003
    Assignees: Mountain View Pharmaceuticals, Inc., Duke University
    Inventors: L. David Williams, Michael S. Hershfield, Susan J. Kelly, Mark G. P. Saifer, Merry R. Sherman