Abstract: This document relates to methods and materials for treating T cell cancers. For example, a composition containing one or more bispecific molecules targeting T cell receptor £ chain constant region (TRBC) can be administered to a mammal having a T cell cancer to treat the mammal. For example, this document provides methods and materials for using one or more bispecific molecules to treat a mammal having a T cell cancer.

Abstract: This document relates to methods and materials for treating T cell cancers. For example, a composition containing one or more bispecific molecules can be administered to a mammal having a T cell cancer to treat the mammal. For example, methods and materials for using one or more bispecific molecules to treat a mammal having a T cell cancer are provided.

Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: A computing device, a system, and a method are provided to receive a number of inputs associated with one or more sensors of the computing device. One or more processors are configured to determine input data based on the number of inputs and authenticate a user account based on the input data. A communication interface is enabled to communicate with one or more devices based on the authentication. Further, the system may aggregate the input data based on the number of inputs. The system may determine identity data of the user account based on the aggregation. The system may transmit an indication of the identity data to the computing device.

Abstract: A computing device, a system, and a method are provided to receive a number of inputs associated with one or more sensors of the computing device. One or more processors are configured to determine input data based on the number of inputs and authenticate a user account based on the input data. A communication interface is enabled to communicate with one or more devices based on the authentication. Further, the system may aggregate the input data based on the number of inputs. The system may determine identity data of the user account based on the aggregation. The system may transmit an indication of the identity data to the computing device.

Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

Abstract: A computing device, a system, and a method are provided to receive a number of inputs associated with one or more sensors of the computing device. One or more processors are configured to determine input data based on the number of inputs and authenticate a user account based on the input data. A communication interface is enabled to communicate with one or more devices based on the authentication. Further, the system may aggregate the input data based on the number of inputs. The system may determine identity data of the user account based on the aggregation. The system may transmit an indication of the identity data to the computing device.

Abstract: Mutant epitopes encoded by cancer genes are virtually always located in the interior of cells, making them invisible to conventional antibodies. We generated single chain variable fragments (scFvs) specific for mutant peptides presented on the cell surface by human leukocyte antigen (HLA) molecules. These scFvs can be converted to full-length antibodies, termed MANAbodies, targeting “Mutation Associated Neo-Antigens” bound to HLA. A phage display library representing a highly diverse array of single-chain variable fragment sequences was first designed and constructed. A competitive selection protocol was then used to identify clones specific for peptides bound to pre-defined HLA types. In this way, we obtained scFvs, including one specific for a peptide encoded by a common KRAS mutant and another by a common EGFR mutant. Molecules targeting MANA can be developed that specifically react with mutant peptide-HLA complexes even when these peptides differ by only one amino acid from the normal, wild-type form.

Abstract: A computing device, a system, and a method are provided to receive a number of inputs associated with one or more sensors of the computing device. One or more processors are configured to determine input data based on the number of inputs and authenticate a user account based on the input data. A communication interface is enabled to communicate with one or more devices based on the authentication. Further, the system may aggregate the input data based on the number of inputs. The system may determine identity data of the user account based on the aggregation. The system may transmit an indication of the identity data to the computing device.

Abstract: A computing device, a system, and a method are provided to receive a number of inputs associated with one or more sensors of the computing device. One or more processors are configured to determine input data based on the number of inputs and authenticate a user account based on the input data. A communication interface is enabled to communicate with one or more devices based on the authentication. Further, the system may aggregate the input data based on the number of inputs. The system may determine identity data of the user account based on the aggregation. The system may transmit an indication of the identity data to the computing device.