Patents by Inventor Michael S. Klnch

Michael S. Klnch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EphA2 T cell epitopes and uses therefor
    Patent number: 8574584
    Abstract: EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: November 5, 2013
    Assignee: University of Pittsburgh —of the Commonwealth System of Higher Education
    Inventors: Walter J. Storkus, Michael S. Klnch