Patents by Inventor Michael S. Krangel

Michael S. Krangel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • &ggr;, &dgr; T cell receptor and methods for detection
    Patent number: 6313263
    Abstract: The present invention provides purified polypeptides which comprise at least a portion of a &dgr; T cell receptor polypeptide, a &ggr; T cell receptor polypeptide, a &ggr;, &dgr; T cell receptor complex or a &ggr;, &ggr; T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: November 6, 2001
    Assignees: Astra AB, President and Fellows of Harvard College, Dana-Farber Cancer Institute
    Inventors: Michael B. Brenner, Jack L. Strominger, Johnathan Seidman, Stephen H. Ip, Michael S. Krangel
  • .gamma., .delta. T cell receptor and methods for detection
    Patent number: 5601822
    Abstract: The present invention provides purified polypeptides which comprise at least a portion of a .delta. T cell receptor polypeptide, a .gamma. T cell receptor polypeptide, a .gamma., .delta. T cell receptor complex or a .gamma., .gamma. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: February 11, 1997
    Assignees: T Cell Sciences, Inc., President and Fellows of Harvard College, Dana Farber Cancer Institute
    Inventors: Michael B. Brenner, Jack L. Strominger, Johnathan Seidman, Stephen H. Ip, Michael S. Krangel
  • .GAMMA., .delta.T cell receptor and methods and detection
    Patent number: 5340921
    Abstract: The present invention provides purified polypeptides which comprise at least a portion of a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide, a .gamma., .delta.T cell receptor complex or a .gamma., .gamma.T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: August 23, 1994
    Assignees: T Cell Sciences, Inc., The Dana-Farber Cancer Institute, President & Fellows of Harvard College
    Inventors: Michael B. Brenner, Jack L. Strominger, Johnathan Seidman, Stephen H. Ip, Michael S. Krangel
  • Method for detecting the .gamma.,.delta. T cell receptor
    Patent number: 5286653
    Abstract: The present invention provides purified polypeptides which comprise at least a portion of a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide or a .gamma.,.delta. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided. Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: February 15, 1994
    Assignees: T Cell Diagnostics, Inc., Dana Farber Cancer Institute, President and Fellows of Harvard College
    Inventors: Michael B. Brenner, Jack L. Strominger, Jonathan Seidman, Stephen H. Ip, Michael S. Krangel
  • Methods for detection of human gamma, .gamma. T cell receptor
    Patent number: 5260223
    Abstract: The present invention provides purified polypeptides which comprise at least a portion of a .delta. T cell receptor polypeptide, a .gamma. T cell receptor polypeptide, a .gamma., .gamma. T cell receptor complex or a .gamma., .delta. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.Additionally, methods for detecting T cells which have within them or on tThis invention was supported by several NIH grants, and the Government has certain rights to the invention.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: November 9, 1993
    Assignees: President & Fellows of Harvard College, Dana Farber Cancer Institute & T Cell Diagnostics, Inc.
    Inventors: Michael B. Brenner, Jack L. Strominger, John G. Seidman, Stephen H. Ip, Michael S. Krangel
  • Human .gamma., .delta.T cell antigen receptor polypeptides and nucleic acids
    Patent number: 5185250
    Abstract: The present invention is directed to purified polypeptides comprising the .gamma. T cell antigen receptor (TCR) polypeptide, the .delta. TCR polypeptide, a .gamma., .delta. TCR complex, or a fragment thereof containing an epitope. The invention also relates to nucleic acid sequences encoding such polypeptides, and subsequences thereof. In specific embodiments, the invention relates to nucleic acid sequences comprising variable, diversity, joining, or constant regions of the .delta. TCR gene sequence. The invention also relates to monoclonal antibodies specifically reactive with an epitope of the gamma or delta TCR polypeptides. In specific embodiments, these antibodies are reactive with the delta constant region, the delta variable region, or gamma constant region. Such antibodies can be identified by detecting co-modulation of the CD3 antigen. In another embodiment, the invention relates to compositions comprising substantially purified cells which express both a .gamma., .delta. TCR and the CD4 antigen.
    Type: Grant
    Filed: January 13, 1989
    Date of Patent: February 9, 1993
    Assignees: T Cell Sciences, Inc., Dana Farber Cancer Institute, President & Fellows of Harvard College
    Inventors: Michael B. Brenner, Jonathan Seidman, Jack L. Strominger, Stephen H. Ip, Michael S. Krangel, Hamid Band
  • Nucleic acids encoding the delta chain of the T cell antigen receptor
    Patent number: 5024940
    Abstract: The present invention provides purified polypeptides which comprises at least a portion of a a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide, a .gamma..delta.T cell receptor complex or a .gamma..delta.T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.Additonally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: June 18, 1991
    Assignees: T Cell Sciences, Inc., Dana-Farber Cancer Institute, President & Fellows of Harvard College
    Inventors: Michael B. Brenner, Jack L. Strominger, Jonathan Seidman, Stephen H. Ip, Michael S. Krangel