Abstract: Various examples are provided for simultaneous bilateral brain stimulation. In one example, a method includes applying a first stimulation signal at a first frequency through a feature-side implanted neural stimulator (INS) on a first side of a brain, applying a second stimulation signal at a second frequency through a non-feature-side INS on a second side of the brain, and detecting a stimulation interference signal with the non-feature-side INS. The first stimulation signal can be a pulsed signal and the second simulation signal can be a continuous signal at a low stimulation voltage, and the stimulation interference signal at an interference frequency based upon the first and second frequencies. In another example, a neural stimulation system including a feature-side neural stimulator and a non-feature-side neural stimulator implanted on first and second sides of the brain and neural stimulation circuitry coupled to the neural stimulators.

Abstract: The present disclosure provides methods for reducing Lewy Bodies in the central nervous system of a subject in need thereof by administering a T cell that is specific for an ?-synuclein mutant to the subject.

Abstract: New methods for deep brain stimulation (DBS) surgery using two or more electrical leads are provided. The methods are useful for treating a wide variety of brain-associated disorders including movement-related disorders, psychiatric disorders, metabolic/eating disorders, memory disorders, and pain. Methods featuring stimulation of distinct target areas of a subject's brain, such as the thalamic ventralis intermedius (VIM) and the ventralis oralis (VOA/VOP) using multiple electrical leads for treatment of tremor provide superior clinical outcomes to stimulation with single leads implanted in these target areas.

Abstract: This invention provides computerized image guidance systems for deep brain stimulation (DBS) surgery and related methods that improve accuracy of positioning of electrodes in the brains of subjects. Image guidance systems in accordance with the present invention incorporate advanced features such as capability of displaying, in any desired plane of view, a digitized three-dimensional neuroanatomical brain map that can be form fitted to a patient's medical images, such as brain MR images, and capability of displaying on the patient's medical images both the contours of anatomic structures from a digitized brain map, and digitized electrode recording data obtained intra-operatively.

Abstract: A system and method for neurosurgery candidacy assessment includes multiple data sources, wherein results of tests from at least some of the multiple data sources are integrated. A neurosurgery candidacy assessment report including a recommendation regarding candidacy for neurosurgery is provided based on the integrated results. The multiple data sources may include cognitive tests, a background data source, a medical data source, an anxiety/depression data source, and a motor skills data source. The medical data source may include a FLASQ-PD questionnaire.

Abstract: New methods for deep brain stimulation (DBS) surgery using two or more electrical leads are provided. The methods are useful for treating a wide variety of brain-associated disorders including movement-related disorders, psychiatric disorders, metabolic/eating disorders, memory disorders, and pain. Methods featuring stimulation of distinct target areas of a subject's brain, such as the thalamic ventralis intermedius (VIM) and the ventralis oralis (VOA/VOP) using multiple electrical leads for treatment of tremor provide superior clinical outcomes to stimulation with single leads implanted in these target areas.