Patents by Inventor Michael S. Placzek

Michael S. Placzek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delivery of therapeutic alkaloid compounds
    Patent number: 12269800
    Abstract: Disclosed are prodrug compounds that can be converted to mesembrine under biologically relevant conditions, such as hydrolysis in vivo; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.
    Type: Grant
    Filed: January 5, 2024
    Date of Patent: April 8, 2025
    Assignee: Sensorium Therapeutics, Inc.
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20250059156
    Abstract: Disclosed are compounds that are derivatives of mesembrine or mesembrenone, and related methods of preparing and using the compounds. The disclosed compounds inhibit PDE4.
    Type: Application
    Filed: August 9, 2024
    Publication date: February 20, 2025
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20250051277
    Abstract: Disclosed are prodrug compounds that can be converted to mesembrine under biologically relevant conditions, such as hydrolysis in vivo; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.
    Type: Application
    Filed: October 28, 2022
    Publication date: February 13, 2025
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20250011281
    Abstract: Disclosed are compounds that are derivatives of mesembranol or mesembrenol, and related methods of preparing and using these compounds. The disclosed compounds may inhibit SERT.
    Type: Application
    Filed: August 22, 2024
    Publication date: January 9, 2025
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20240409566
    Abstract: Disclosed are compounds that can be converted to mesembrine under biologically relevant conditions, such as acid hydrolysis at body temperature; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.
    Type: Application
    Filed: August 16, 2024
    Publication date: December 12, 2024
    Inventors: Michael S. Placzek, Simon N. Pettit
  • DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20240408119
    Abstract: Disclosed are compounds that can be converted to mesembrine under physiologically relevant conditions, and related methods of preparing and using the compounds.
    Type: Application
    Filed: August 9, 2024
    Publication date: December 12, 2024
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • INHIBITING SEROTONIN TRANSPORTER PROTEIN (5-HTT)
    Publication number: 20240398759
    Abstract: Disclosed are compositions comprising mesembranol, such as (?) mesembranol or (?) 6-epi-mesembranol. The disclosed compositions can be used in methods of inhibiting SERT. Methods of treatment for anxiety or depression are also provided, including methods comprising the oral administration to a subject in need thereof a therapeutically effective amount of certain pharmaceutical compositions.
    Type: Application
    Filed: August 16, 2024
    Publication date: December 5, 2024
    Inventors: Michael S. Placzek, Jacob M. Hooker
  • DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20240246910
    Abstract: Disclosed are prodrug compounds that can be converted to mesembrine under biologically relevant conditions, such as hydrolysis in vivo; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.
    Type: Application
    Filed: January 5, 2024
    Publication date: July 25, 2024
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • Delivery of therapeutic alkaloid compounds
    Patent number: 11999694
    Abstract: Disclosed are prodrug compounds that can be converted to mesembrine under biologically relevant conditions, such as hydrolysis in vivo; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: June 4, 2024
    Assignee: Sensorium Therapeutics, Inc.
    Inventors: Jacob M. Hooker, Michael S. Placzek
  • DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
    Publication number: 20230159455
    Abstract: Disclosed are prodrug compounds that can be converted to mesembrine under biologically relevant conditions, such as hydrolysis in vivo; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.
    Type: Application
    Filed: October 28, 2022
    Publication date: May 25, 2023
    Inventors: Jacob M. Hooker, Michael S. Placzek