Abstract: The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.

Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.

Abstract: An electrical connector adapted to protect its signal circuits against power surges for at least ESD protection, having a conductive shell (60) with a transverse flange (64) on which are mounted components such as diodes (100) having first electrodes soldered thereto for grounding. A plurality of discrete straps (114) extend from second electrodes of the diodes to respective the contacts (20) and define circuits electrically connecting the contacts to the diodes. The dielectric housing (30) includes slots (46) along side surfaces within which intermediate strap sections 118 of the straps are retained, and a lateral flange (42) of the housing coextends along the transverse shell flange on each side and has recesses (54) within which the diodes are disposed, with channels (48) extending inwardly along the lateral flanges to the slots to retain transverse contact sections of said straps therein.

Abstract: An electrical connector adapted to protect its signal circuits against power surges for at least ESD protection, having a conductive shell (60) with a transverse flange (64) on which are mounted components such as diodes (100) having first electrodes soldered thereto for grounding. A plurality of discrete straps (114) extend from second electrodes of the diodes to respective the contacts (20) and define circuits electrically connecting the contacts to the diodes. The dielectric housing (30) includes slots (46) along side surfaces within which intermediate strap sections 118 of the straps are retained, and a lateral flange (42) of the housing coextends along the transverse shell flange on each side and has recesses (54) within which the diodes are disposed, with channels (48) extending inwardly along the lateral flanges to the slots to retain transverse contact sections of said straps therein.