Patents by Inventor Michael S Su

Michael S Su has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallization of C-Jun N-Terminal Kinase 3 (JNK3)
    Patent number: 8002891
    Abstract: The present invention relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: August 23, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Xiaoling Xie, Yong Gu, William Markland, Michael S. Su, Paul R. Caron, Edward Fox, Keith P. Wilson
  • Crystallizable JNK complexes
    Publication number: 20090186394
    Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.
    Type: Application
    Filed: April 25, 2008
    Publication date: July 23, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Xiaoling Xie, Yong Gu, William Markland, Michael S. Su, Paul R. Caron, Edward Fox, Keith P. Wilson
  • Methods of designing inhibitors for JNK kinases
    Patent number: 7383135
    Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site-binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: June 3, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Xiaoling Xie, Yong Gu, William Markland, Michael S Su, Paul R Caron, Edward Fox, Keith P Wilson