Abstract: A method includes applying a coating composition to a substrate through a high transfer efficiency applicator, wherein the coating composition comprises a polyamide wax; wherein the coating composition has a wet film thickness of at least about 30 microns measured at about 45 degrees without visible sag after cure, wherein the viscosity measured at a shear rate of about 1 s-1 recovers, after a high shear rate of about 10000 s-1 is applied for about 20 seconds, to within about 95% of a steady state viscosity achieved at greater than about 100 seconds of continuous shearing at about 1 s-1, in less than about 5 seconds; and wherein the coating composition has a complex viscosity measured at a temperature of about 60° C. that is reduced to from about 60 to about 500 mPa-s when the complex viscosity measured at about 30° C. is from about 800 to about 8000 mPa-s.

Abstract: A method of preparing a multi-layer coated article is disclosed. The method utilizes a high transfer efficiency applicator comprising a plurality of nozzles configured to apply a stream or droplets of a coating composition. The method includes providing a substrate bearing a partially-dehydrated aqueous coating layer, preparing a compatible coating composition, and applying the compatible coating composition to the substrate. The compatible coating composition is prepared by providing a test layer of the partially-dehydrated aqueous coating layer, applying a plurality of candidate cosolvents to the test layer, identifying at least one compatible cosolvent, and formulating the compatible coating composition as a waterborne fluid suitable for overspray-free application.

Abstract: Coating application systems and methods of using the same are provided. In an exemplary embodiment, a coating application system includes a support system defined in an XYZ coordinate system, where the XYZ coordinate system includes an X axis, a Y axis, and a Z axis that are all perpendicular to each other. The X and Y axes define an XY plane at a zero Z axis position. The support system includes a first and second bar both of which run in the X direction of the XY plane. A traveling rod is connected to the first and second bars and is configured to run in the X direction. A plurality of printheads are connected to the traveling rod, where the plurality of printheads include a first and second printhead that are configured to articulate independent of each other.

Abstract: A method of applying a coating composition to a substrate utilizing a high transfer efficiency applicator is disclosed and provides coated article. The high transfer efficiency applicator comprises a plurality of nozzles, each being configured to apply a stream or stream of droplets of the coating composition to a substrate substantially without atomization, and an infrared emitter. The method includes providing a coating composition for overspray-free application to the high transfer efficiency applicator, and applying the coating composition via disposing a plurality of lines of the coating composition onto the substrate via the plurality of nozzles. The method also includes irradiating the coating composition via the infrared emitter during and/or after application to give an irradiated coating composition, and thereby form an overspray free coating layer on the substrate.

Abstract: A method of preparing a coated article is disclosed. The method includes providing a substrate bearing a partially-dehydrated aqueous coating layer. The method further includes providing a coating composition to a high transfer efficiency applicator, the high transfer efficiency applicator comprising a plurality of nozzles each being configured to apply a stream of the coating composition to a substrate substantially without atomization. The coating composition is a waterborne fluid that exhibits a near-Newtonian viscosity profile, and comprises a binder, a crosslinker, and a thickener. The method further includes applying the coating composition to the substrate with the high transfer efficiency applicator via disposing a plurality of lines of the coating composition onto the partially-dehydrated aqueous coating layer of the substrate via the plurality of nozzles, thereby forming an overspray free coating layer thereon.

Abstract: This disclosure provides a method of applying a first coating composition and a second coating composition to a substrate. The method includes providing the substrate defining a first target area and a second target area which define a gap there between of less than about 2 mm; applying the first coating composition via a first high transfer efficiency applicator to the first target area at a wet film thickness of from about 5 to about 150 microns; and applying the second coating composition via a second high transfer efficiency applicator to the second target area at a wet film thickness of from about 5 to about 150 microns to form a continuous layer of a combination of the first and second coating compositions that extends across the gap and also extends across at least an additional portion of the substrate.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a first and a second coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a first reservoir a second reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator is configured to receive the first coating composition from the first reservoir and configured to expel the first coating composition through the first nozzle orifice to the first target area of the substrate. The second high transfer efficiency applicator is configured to receive the second coating composition from the second reservoir and configured to expel the second coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: Methods of coating a substrate are provided. In an exemplary embodiment, a coating composition is applied to the substrate with a high transfer efficiency applicator to produce a coating layer, where the high transfer efficiency applicator and the substrate remain spatially separate while the coating composition is applied. A droplet of the coating composition expelled from the high transfer efficiency applicator has a particle size of about 10 microns or greater. The coating composition has a viscosity of from about 1,000 to about 1,000,000 centipoise when the coating composition is subject to a shear rate of about 0.1 reciprocal seconds (s?1). However, the coating composition is non-Newtonian such that a coating composition viscosity decreases when the shear rate is increased to the coating composition. The coating layer is impinged with a gas such that a coating layer surface moves upon impingement with the gas.

Abstract: A method includes applying a coating composition to a substrate through a high transfer efficiency applicator wherein the coating composition has a pH of greater than about 7 and comprises: A. a resin dispersion comprising a latex, a polyurethane, or combinations thereof; B. an optional cross-linker; C. an optional pigment; D. water; E. a water-soluble solvent; and F. at least one rheology control agent chosen from an alkali swellable emulsion, a layered silicate, and combinations thereof; wherein the coating composition has a viscosity of about 20 to about 100 cps as determined using ASTM 7867-13 with cone-and-plate or parallel plates at a shear rate of 1000 sec-1, and wherein the coating composition has a wet film thickness of at least 20 microns measured at about 45 degrees without visible sag.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A method includes applying a coating composition to a substrate through a high transfer efficiency applicator to form the coating layer on the substrate wherein a loss of volatiles is less than about 0.5 weight, and wherein the coating composition comprises: A. a resin comprising an acrylic, a polyester, or combinations thereof; B. a melamine cross-linker; C. an optional pigment; D. an organic solvent; and E. at least one polyurea crystal sag control agent that is the reaction product of an amine and an isocyanate, that has a melting point of from about 50° C. to about 150° C., and that is present in an amount of from about 0.1 to about 4 weight percent based on a total weight of the coating composition; and wherein the coating composition has a wet film thickness of at least about 30 microns measured at about 45 degrees without visible sag.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a first and a second coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a first reservoir a second reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator is configured to receive the first coating composition from the first reservoir and configured to expel the first coating composition through the first nozzle orifice to the first target area of the substrate. The second high transfer efficiency applicator is configured to receive the second coating composition from the second reservoir and configured to expel the second coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of ?-secretase.

Abstract: This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of ?-secretase.

Abstract: Aspects of the invention relate to substituted aryl propylamino-oxy-analogs and uses thereof. Aspects of the invention relate to compositions that are inhibitors of ?-secretase and uses thereof for treating subjects having, or at risk of developing, Alzheimer's disease.

Abstract: Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-?-peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat ?-amyloid-associated diseases, notably Alzheimer's disease.