Abstract: A sole structure for an article of footwear includes a midsole having a top surface, a bottom surface opposite the top surface, and a peripheral surface extending between the top surface and the bottom surface. The bottom surface includes a recess defining a first opening in the peripheral surface. The sole structure for an article of footwear also includes an insert disposed within the recess and including a first material having a first gloss unit value and a second material disposed on an outer surface of the first material and having a second gloss unit value. The second material is at least partially disposed within the first opening.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a first and a second coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a first reservoir a second reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator is configured to receive the first coating composition from the first reservoir and configured to expel the first coating composition through the first nozzle orifice to the first target area of the substrate. The second high transfer efficiency applicator is configured to receive the second coating composition from the second reservoir and configured to expel the second coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: Methods of coating a substrate are provided. In an exemplary embodiment, a coating composition is applied to the substrate with a high transfer efficiency applicator to produce a coating layer, where the high transfer efficiency applicator and the substrate remain spatially separate while the coating composition is applied. A droplet of the coating composition expelled from the high transfer efficiency applicator has a particle size of about 10 microns or greater. The coating composition has a viscosity of from about 1,000 to about 1,000,000 centipoise when the coating composition is subject to a shear rate of about 0.1 reciprocal seconds (s?1). However, the coating composition is non-Newtonian such that a coating composition viscosity decreases when the shear rate is increased to the coating composition. The coating layer is impinged with a gas such that a coating layer surface moves upon impingement with the gas.

Abstract: A method includes applying a coating composition to a substrate through a high transfer efficiency applicator wherein the coating composition has a pH of greater than about 7 and comprises: A. a resin dispersion comprising a latex, a polyurethane, or combinations thereof; B. an optional cross-linker; C. an optional pigment; D. water; E. a water-soluble solvent; and F. at least one rheology control agent chosen from an alkali swellable emulsion, a layered silicate, and combinations thereof; wherein the coating composition has a viscosity of about 20 to about 100 cps as determined using ASTM 7867-13 with cone-and-plate or parallel plates at a shear rate of 1000 sec-1, and wherein the coating composition has a wet film thickness of at least 20 microns measured at about 45 degrees without visible sag.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A method includes applying a coating composition to a substrate through a high transfer efficiency applicator to form the coating layer on the substrate wherein a loss of volatiles is less than about 0.5 weight, and wherein the coating composition comprises: A. a resin comprising an acrylic, a polyester, or combinations thereof; B. a melamine cross-linker; C. an optional pigment; D. an organic solvent; and E. at least one polyurea crystal sag control agent that is the reaction product of an amine and an isocyanate, that has a melting point of from about 50° C. to about 150° C., and that is present in an amount of from about 0.1 to about 4 weight percent based on a total weight of the coating composition; and wherein the coating composition has a wet film thickness of at least about 30 microns measured at about 45 degrees without visible sag.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: A system for applying a first and a second coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a first reservoir a second reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator is configured to receive the first coating composition from the first reservoir and configured to expel the first coating composition through the first nozzle orifice to the first target area of the substrate. The second high transfer efficiency applicator is configured to receive the second coating composition from the second reservoir and configured to expel the second coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of ?-secretase.

Abstract: This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of ?-secretase.

Abstract: Aspects of the invention relate to substituted aryl propylamino-oxy-analogs and uses thereof. Aspects of the invention relate to compositions that are inhibitors of ?-secretase and uses thereof for treating subjects having, or at risk of developing, Alzheimer's disease.

Abstract: Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-?-peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat ?-amyloid-associated diseases, notably Alzheimer's disease.

Abstract: Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors preferably inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-? peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat ?-amyloid-associated diseases, notably Alzheimer's disease.

Abstract: Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&bgr; peptide. Methods are provided for administering the novel compounds to treat &bgr;-amyloid-associated diseases, notably Alzheimer's disease.

Abstract: Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors preferably inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&bgr; peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat &bgr;-amyloid-associated diseases, notably Alzheimer's disease.

Abstract: Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-&bgr; peptide. Methods are provided for administering the novel compounds to treat &bgr;-amyloid-associated diseases, notably Alzheimer's disease.

Abstract: Alumina fiber modified by stabilized zirconia has improved strength and strength retention after high temperature exposure.