Patents by Inventor Michael Sabio

Michael Sabio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20070135502
    Abstract: Compounds of the formula provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X.
    Type: Application
    Filed: January 4, 2007
    Publication date: June 14, 2007
    Inventors: Andrew Bach, Prasad Kapa, George Lee, Eric Loeser, Michael Sabio, James Stanton, Thalaththani Vedananda
  • 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases
    Publication number: 20070060582
    Abstract: This invention relates to compounds of the formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.
    Type: Application
    Filed: September 23, 2004
    Publication date: March 15, 2007
    Inventors: Cynthia Fink, Lawrence Perez, Timothy Ramsey, Naeem Yusuff, Richard Versace, David Batt, Michael Sabio, Sunkyu Kim
  • 2-Aminopyrimidine derivatives as raf kinase inhibitors
    Publication number: 20060293340
    Abstract: This application discloses compounds that inhibit Raf kinase having the formula (I), wherein R1 is a phenyl radical or a heteroaryl radical; and R2 is a phenyl radical; or an N-oxide or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of proliferative diseases, such as cancer.
    Type: Application
    Filed: June 11, 2004
    Publication date: December 28, 2006
    Applicant: NOVARTIS AG
    Inventors: David Batt, Timothy Ramsey, Michael Sabio
  • Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
    Publication number: 20050080080
    Abstract: The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.
    Type: Application
    Filed: September 29, 2004
    Publication date: April 14, 2005
    Inventors: Frederick Kinder, Kenneth Bair, Timothy Ramsey, Michael Sabio
  • Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
    Publication number: 20050049249
    Abstract: The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.
    Type: Application
    Filed: September 28, 2004
    Publication date: March 3, 2005
    Inventors: Frederick Kinder, Kenneth Bair, Timothy Ramsey, Michael Sabio