Abstract: Provided are labeled antibody conjugates for use in a method of diagnosing ALS or monitoring drug therapy and/or progression of ALS by in vivo detecting and tracing misfolded SOD1 by immunoimaging in a subject, compositions and kits comprising said conjugates and methods of in vivo immunoimaging of superoxide dismutase (SOD1) useful as a marker of amyotrophic lateral sclerosis (ALS) or efficacy of drug therapy of ALS in subject using these conjugates. Furthermore, SOD1-antibodies specific for misfolded and/or aggregated SOD1 are provided for use in treatment of bone and/or joint related diseases.

Abstract: Transthyretin (TTR) is a soluble protein involved in thyroxin and retinol transport in the body. Under specific conditions the TTR protein adopts misfolded, misassembled and/or aggregated TTR conformations and becomes toxic, which can lead to transthyretin-mediated amyloidosis (ATTR). Provided herein are, inter alia, compositions (e.g., pharmaceutical compositions) and related articles of manufacture that contain an anti-TTR antibody or antigen fragment thereof. Additionally, provided herein are, inter alia, methods of treating or preventing ATTR using the pharmaceutical compositions described herein.

Abstract: Provided are pharmaceutical formulations and dosing regimen for antibody-based treatment of amyotrophic lateral sclerosis (ALS).

Abstract: An assembly carrier of a vehicle door has at least one break-out element, which is connected to the material of the assembly carrier via at least one peripheral weakened region. The weakened region has a lower material thickness than the remainder of the assembly carrier material. The weakened region acts as a predetermined breaking point and forms a periphery of a service opening. The weakened region is arranged in a ring all around the break-out element. The break-out element is jointly formed with the assembly carrier in a common injection mold.

Abstract: Provided is a novel high sensitive method for assaying misfolded SOD1 in a body fluid of a subject, in particular in the cerebrospinal fluid. This method is based on a novel highly sensitive immunoassay making use of a unique epitope of SOD1 and corresponding anti-SOD1 antibodies. In addition, kits comprising the components of the immunoassay are provided.

Abstract: An assembly carrier of a vehicle door has at least one break-out element, which is connected to the material of the assembly carrier via at least one peripheral weakened region. The weakened region has a lower material thickness than the remainder of the assembly carrier material. The weakened region acts as a predetermined breaking point and forms a periphery of a service opening. The weakened region is arranged in a ring all around the break-out element. The break-out element is jointly formed with the assembly carrier in a common injection mold.

Abstract: A carrier component for a vehicle, e.g. in the form of an assembly or module carrier for a vehicle door is provided. The carrier component comprises a sealing channel at least in a protruding region in which a portion for a functional component protruding beyond the edge of the carrier base surface or for a functional component arranged to protrude from the carrier component extends across the sealing channel in cross-section is formed by at least two legs which each define an outer edge of the sealing channel and whose ends lie in a channel plane which extends inclined relative to a carrier plane defined by the carrier base surface, so that the sealing channel is open in a direction in space defining the carrier plane and a seal also can easily be injection-molded to the carrier component in the protruding region.

Abstract: A carrier component for a vehicle, e.g. in the form of an assembly or module carrier for a vehicle door is provided. The carrier component comprises a sealing channel at least in a protruding region in which a portion for a functional component protruding beyond the edge of the carrier base surface or for a functional component arranged to protrude from the carrier component extends across the sealing channel in cross-section is formed by at least two legs which each define an outer edge of the sealing channel and whose ends lie in a channel plane which extends inclined relative to a carrier plane defined by the carrier base surface, so that the sealing channel is open in a direction in space defining the carrier plane and a seal also can easily be injection-molded to the carrier component in the protruding region.

Abstract: An assembly carrier for installation into a motor vehicle includes a large-area carrier body molded at least partially from fiber-reinforced plastic, fastening points, which are provided on the carrier body, for fastening functional components of a motor vehicle to the carrier body, and a gate mark which projects from the carrier body and which represents a section of the path along which the molding compound for molding the assembly carrier was conducted into a cavity, which forms the carrier body, of a molding die. The gate mark has at least one longitudinally extended gate section which is curved in cross section through the carrier body and the gate mark and whose longitudinal sides which are situated opposite, and which face away from, one another run in each case along a curved path and merge in each case along the respective path into the carrier body.

Abstract: A window lift system includes a motor drive assembly (10) constructed and arranged to control movement window glass of a vehicle, and a door module (35) to which the drive assembly is coupled. The door module has surface features (36) disrupting a surface (37) of the door module to reduce the transfer of vibration energy from the door module to the drive assembly or vise versa. In an embodiment, the door module includes a diaphragm (34) and the surface features are annular, undulating, wave-like features in the diaphragm.

Abstract: A window lift system includes a motor drive assembly (10) constructed and arranged to control movement window glass of a vehicle, and a door module (35) to which the drive assembly is coupled. The door module has surface features (36) disrupting a surface (37) of the door module to reduce the transfer of vibration energy from the door module to the drive assembly or vise versa. In an embodiment, the door module includes a diaphragm (34) and the surface features are annular, undulating, wave-like features in the diaphragm.

Abstract: An assembly carrier for installation into a motor vehicle is provided. The assembly carrier comprising a large-area carrier body which is molded at least partially from fiber-reinforced plastic, fastening points, which are provided on the carrier body, for fastening functional components of a motor vehicle to the carrier body, and a gate mark which projects from the carrier body and which represents a section of the path along which the molding compound for molding the assembly carrier was conducted into a cavity, which forms the carrier body, of a molding die. The gate mark has at least one longitudinally extended gate section which is curved—in cross section through the carrier body and the gate mark—and whose longitudinal sides which are situated opposite, and which face away from, one another run in each case along a curved path and merge in each case along the respective path into the carrier body.