Abstract: Pharmaceutical formulations with a tropomyosin-related kinase inhibitor (“Trk inhibitor”) are disclosed. The pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine in microcrystalline suspension formulations in its monohydrate form, which shows improved characteristics over the anhydrate form, and in extended release formulations. The extended release pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine-loaded microspheres.

Abstract: Provided herein are compositions that include a benzenesulfonamide-containing NSAID, silk fibroin, and a gelling agent. Also provided are kits that include any of these compositions, and methods of making any of these compositions. Also provided are methods of treating an inflammatory and/or pain condition in a subject and methods of reducing inflammation, pain, or fever in a subject in need thereof, that include administering a therapeutically effective amount of any of these compositions.

Abstract: Various splice connector assemblies are disclosed. The splice connector assembly can include a connection unit mating a female and male terminals. The splice connector assembly can include an outer housing with an inner passage configured to receive the terminals. A first securing mechanism can be engaged with a first end of the outer housing and a second securing mechanism can be engaged with a second end of outer housing. The first and second securing mechanisms can each include a coupling nut engaged with the housing, a washer that is non-rotatably connected to the housing, and a sealing gland that comprises an aperture having a non-concentric cross sectional shape.

Abstract: Various connection interfaces are disclosed. In some embodiments, the connection interface includes a receptacle and a connector. The receptacle can be configured to be positioned in the wall of an electrical device. The receptacle can comprise a first set of electrical contacts and a channel. The connector can be configured to be matingly engaged with the receptacle in an engaged state and to be separated from the receptacle in a disengaged state. The connector can comprise a second set of electrical contacts. Some embodiments are configured such that angled surfaces of the channel and boss interact as the connector is moved into engagement with the receptacle. This can guide the connector into the receptacle such that the first and second sets of electrical contacts are in electrical communication with each other.

Abstract: Various interconnect assemblies are disclosed. The interconnect assembly can include an insert having a hook protrusion that fits into a slot of a receiving region. The hook protrusion can have a curved surface that helps the hook protrusion slide into a slot as the insert is rocked toward the receiving region to seat the insert in the receiving region. The receiving region can have a latch that snaps over a key portion of the insert to keep the insert seated in the receiving region.

Abstract: Pharmaceutical formulations with a tropomyosin-related kinase inhibitor (“Trk inhibitor”) are disclosed. The pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine in microcrystalline suspension formulations in its monohydrate form, which shows improved characteristics over the anhydrate form, and in extended release formulations. The extended release pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine-loaded microspheres.

Abstract: A crimp contact is provided where the axes of the contact form a non-linear angle, such as a 90° angle. The crimp contact can be a multi-part contact with a front contact portion that is attached in a removable or fixed manner to the rear crimp contact portion. The front contact portion can be attached to the rear crimp contact portion using a threaded connector to form a threaded attachment.

Abstract: Various connection interfaces are disclosed. In some embodiments, the connection interface includes a receptacle and a connector. The receptacle can be configured to be positioned in the wall of an electrical device. The receptacle can comprise a first set of electrical contacts and a channel. The connector can be configured to be matingly engaged with the receptacle in an engaged state and to be separated from the receptacle in a disengaged state. The connector can comprise a second set of electrical contacts. Some embodiments are configured such that angled surfaces of the channel and boss interact as the connector is moved into engagement with the receptacle. This can guide the connector into the receptacle such that the first and second sets of electrical contacts are in electrical communication with each other.

Abstract: A crimp contact is provided where the axes of the contact form a non-linear angle, such as a 90° angle. The crimp contact can be a multi-part contact with a front contact portion that is attached in a removable or fixed manner to the rear crimp contact portion. The front contact portion can be attached to the rear crimp contact portion using a threaded connector to form a threaded attachment.

Abstract: The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and/or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.

Abstract: A pair of electrical connectors (10, 12) can be mated by inserting a pair of guide pins (50a, 50b) lying on side axes (22, 24) of a first connector, into a pair of guide sleeve passages (70a, 70b) that lie on side axes of a second connector. The first and second connectors each can be adjusted to laterally shift front parts of the guide pins and front parts of the guide sleeves, so the distance A? between the two pins and the distance B? between the two sleeves is slightly reduced or slightly increased to prevent one of the connectors from mating with a third connector.

Abstract: A compact electrical connector has first contacts (32) with a first characteristic impedance (50 ohms) and second contacts (34) with a second characteristic impedance (100 ohms), with each set of contacts having a separate electrical ground (G1, G2). The first contacts lie in passages of a first insulative holder (24), with the first contacts arranged in three rows (62, 64, 66) wherein the middle row is offset from the top and bottom rows to maintain a constant contact spacing. The second contacts (34) lie in two vertically elongated insulative holders (26, 28) that each lies at one end of the first holder, with each holder having a grounded second contact (56) and with each holder projecting into a recess (84) at the end of the frame that receives the first holder.

Abstract: A connector system includes first and second mateable connectors (12, 14) with coaxial contacts, wherein the first connector has movable center and outer contacts (20, 22) that are each biased forward by a separate spring (24, 26) to engage stationary contact pads (34, 36) of the mating second connector. A stationary tubular insulator (100) surrounds much of the movable center contact, and a stationary sheet metal shield (102) lies around the tubular insulator and within the outer contact. The front end of the movable outer contact forms an internal flange (80) with a hole (84) that allows the front end of the movable center contact to pass through. The shield front-end has an internal flange (112) that lies between the front end of the tubular insulator and the movable outer contact internal flange, to maintain a constant impedance through out the first connector.

Abstract: A battery holder frame (12) that facilitates the removal of a fully installed battery (30) (electrical cell). The frame has top (20), bottom (22), opposite side (24, 26), and back walls (28) that form a cavity (14) that receives a battery by moving the battery rearward into the cavity until the battery abuts the back wall. The back wall upper portion has a bottom edge (66) and leaves an opening (62) below the bottom edge through which the bottom of the battery can move rearward out of the cavity. To remove a fully installed battery, the battery bottom is pushed rearward to cause the battery to pivot so its upper portion (152) moves forward out of the cavity and can be grasped to pull the battery out of the cavity.

Abstract: Coaxial contacts of a second connector (14) are in the form of static pads (34, 36), while coax contacts of a first connector (12) are in the form of spring contacts (40, 42) with pins (52) that engage the static pads. The first connector includes a coax center spring contact (40) positioned to engage a center static pad (34) of the second connector, and the first connector includes a plurality of outer coax spring contacts (42A, 42B, 42C, 42D) positioned to engage the outer static pad (36) of the second connector. When fully mated, a static pad region (90) on the first connector lies facewise adjacent to the outer static pad. The connectors are constructed to mate by pivoting the first connector against the second one, to assure that an outer coax spring contact makes engagement before the center spring contact makes engagement.

Abstract: The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and/or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.