Abstract: The invention relates to a novel fermentative process for the preparation of acarbose. By monitoring and controlling the osmolality in the fermentation solution, a substantial improvement in yield from the fermentation is achieved.

Abstract: An aprotinin with a deletion of the amino acid proline in position 2 or an addition of alanine-(-2)-glutamine-(-1). Such aprotinin is useful as an active ingredient in medicaments.

Abstract: An aprotinin with a deletion of the amino acid proline in position 2 or an addition of alanine-(-2)- glutamine-(-1). Such aprotinin is useful as an active ingredient in medicaments.

Abstract: A process has been developed for the preparation of compounds of the formula ##STR1## wherein R is hydrogen or an optionally substituted alkyl radical, which comprises reacting glucose with a compound of the formula H.sub.2 N-R wherein R has the meaning given above to form a 1-amino-sorbitol of the formula ##STR2## wherein R has the meaning given above,reacting said 1-aminosorbitol with a compound providing a protective group which can be split off under acid conditions and is stable in the subsequent microbiological oxidation process, aerobically oxidizing the compound thus obtained microbiologically to give a protected 6-aminosorbose, splitting off the protective group under acid conditions and hydrogenating the 6-aminosorbose salt thus obtained either after being isolated or in one operation, to give the compound of the formula (I). The products obtained by the process of the invention are useful as .alpha.-glucoside inhibitors.

Abstract: The invention relates to a process for the production of compounds of the formula ##STR1## in which R is hydrogen or optionally substituted alkyl, alkenyl, aralkyl or aryl, by microbiological transformation of ##STR2## follow by catalytic hydrogenation. The compounds obtained are useful for the treatment of diabetes, hyperlipoproteinaemia and adiposity which comprises aerobically cultivates, in the presence of an assimilable source of carbon nitrogen, at a temperature of 20.degree. to 45.degree. C. and pH between 2 and 10 and in the presence of an effective amount of a compound of the formula ##STR3## in which R has the above-given meaning and,R.sub.1 denotes an optionally substituted benzyl radical or an optionally substituted .beta.-alkenyl group,an aerobic microorganism or an extract of aerobic microorganism capable, in a nutrient medium containing a compound of the formula (X), or accumulating an amount of a compound of the formula ##STR4## in which R and R.sub.

Abstract: The invention relates to a process for the production of 6-amino-6-deoxy-L-sorbose which comprises culturing an aerobic micro-organism capable of oxidizing 1-amino-1-deoxy-D-glucitol or an enzymatic extract obtained from said aerobic micro-organism under aerobic conditions and at a suitable temperature in an aqueous nutrient medium containing 1-amino-1-deoxy-D-glucitol or a salt thereof and also containing assimilable sources of carbon, nitrogen and essential trace element to impart said 6-amino-6-deoxy-L-sorbose to said aqueous nutrient medium.