Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.

Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity, at least 80% identity, at least 90% identity, at least 95% identity or at least 99% identity to any of SEQ ID NOs: 1-23 or 32-35 and at least one gRNA.

Abstract: Provided are compositions and methods that utilize Acr proteins with CRISPR Cas proteins to achieve a balance in which Cas proteins retain activity to perform on-target nucleic acid targeting functions (e.g., DNA cleavage for gene editing applications), but are inhibited by one or more Acr proteins to a degree that decreases off-target activity—thus resulting in an increased ratio of on-target to off-target nucleic acid targeting events. For example, provided is a system that includes one or more nucleic acids that comprise: a first nucleotide sequence encoding a Cas effector protein and a second nucleotide sequence encoding an Acr protein, wherein the first, second or both nucleotide sequences are operably linked to a translational control element.

Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.

Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.

Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.

Abstract: Disclosed are gene signatures that may be used to predict the recurrence of colorectal cancer in a human patient. These signatures can be used to determine when to treat a patient with post-operative adjuvant chemotherapy, i.e., when a high risk of colorectal cancer recurrence is predicted.

Abstract: The invention relate to a bus bar holder having a bottom part and a top part detachably connected to the bottom part, between which, when they are connected together, at least one busbar passage is formed, wherein the top part and the bottom part have, on mutually opposite contact surfaces, sliding faces along which they bear against one another and are movable between an open position, in which the top part can be lifted off the bottom part, and a closed position, in which the top part is secured to the bottom part via a tongue-and-groove connection, wherein a releasable latching pawl secures the top part and the bottom part in the closed position. Also described is a corresponding arrangement made up of at least one such busbar holder and at least one busbar.

Abstract: Disclosed are gene signatures that may be used to predict the recurrence of colorectal cancer in a human patient. These signatures can be used to determine when to treat a patient with post-operative adjuvant chemotherapy, i.e., when a high risk of colorectal cancer recurrence is predicted.

Abstract: The invention relate to a bus bar holder having a bottom part and a top part detachably connected to the bottom part, between which, when they are connected together, at least one busbar passage is formed, wherein the top part and the bottom part have, on mutually opposite contact surfaces, sliding faces along which they bear against one another and are movable between an open position, in which the top part can be lifted off the bottom part, and a closed position, in which the top part is secured to the bottom part via a tongue-and-groove connection, wherein a releasable latching pawl secures the top part and the bottom part in the closed position. Also described is a corresponding arrangement made up of at least one such busbar holder and at least one busbar.

Abstract: Apparatus for the touch-safe contacting of a busbar system having multiple busbars, wherein the arrangement has a touch protection housing made of electrically insulating material comprising receptacles for busbars, wherein the touch protection housing has a base having the receptacles and also a cover, which closes the receptacles and is optionally detachable from the base, having an installation side, wherein the arrangement furthermore has a multipole busbar adapter for the electrical contacting of the busbars, which is installed with an adapter housing on the installation side and for this purpose passes through the cover with at least one retaining foot engaging behind the busbars and also with at least one contact element in each case for every busbar to be electrically contacted.

Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.

Abstract: The invention describes an arrangement for the touch-safe contacting of a busbar system comprising multiple busbars, wherein the arrangement has a touch protection housing made of electrically insulating material comprising receptacles for busbars, wherein the touch protection housing has a base having the receptacles and also a cover, which closes the receptacles and is optionally detachable from the base, having an installation side, wherein the arrangement furthermore has a multipole busbar adapter for the electrical contacting of the busbars, which is installed with an adapter housing on the installation side and for this purpose passes through the cover with at least one retaining foot engaging behind the busbars and also with at least one contact element in each case for every busbar to be electrically contacted.

Abstract: Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and Trichoderma host cells having a modification comprising or consisting essentially of disruption or deletion of nucleotide(s) for expression of this cellulose, whereby EGV expression is prevented.

Abstract: Disclosed are gene signatures that may be used to predict the recurrence of colorectal cancer in a human patient. These signatures can be used to determine when to treat a patient with post-operative adjuvant chemotherapy, i.e., when a high risk of colorectal cancer recurrence is predicted.

Abstract: Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and Trichoderma host cells having a modification comprising or consisting essentially of disruption or deletion of nucleotide(s) for expression of this cellulose, whereby EGV expression is prevented.

Abstract: The invention relates to a recovery and/or purification process of hydrophobins involving organic solvents and does not require separation techniques. In particular, the invention relates to a method for selective alcohol precipitation of hydrophobin II.

Abstract: A control box arrangement including at least one control box, the inside of which is sub-divided, or can be sub-divided, into a plurality of compartments which are arranged one above the other and can be closed in a sealing manner by associated doors with a peripheral sealing arrangement acting on the inside of the doors. The doors are connected, by one of the vertical sides thereof, to a frame of the control box in question by hinges in an articulated manner, and can be closed by a closing mechanism on the opposite vertical side. A first hinge section is fixed to a vertical section of the frame by a fixing section, and the door is mounted on an articulated section of the first hinge section in an articulated manner by a second hinge section applied thereto.

Abstract: A control box arrangement including at least one control box which is sub-divided, or can be sub-divided, by vertical wall sections with a horizontal sub-division, into a plurality of cuboid compartments surrounded on all sides. A variable structural design of compartments, particularly functional compartments, for example for low voltage systems, is obtained by providing wall sections including lateral wall sections adapted to the same or different compartment heights, adapted rear wall sections embodied as mounting plates, and horizontal partition bottoms, in order to produce a plurality of horizontal compartments, in the form of pigeonholes, arranged one above the other.

Abstract: A control box arrangement including at least one control box which has a frame constructed from vertical and horizontal frame pieces and which is fitted with, or can be fitted with, mounting parts including mounting rails, for the variable design of the inside of the control box for the division thereof. The frame pieces have rows of mounting holes in a defined pattern. The division of the inside of the control box can be varied by single-component connection pieces for connecting the mounting rails to the frame pieces. The connection pieces include a coupling section which protrudes at a right angle from the connection plane of the associated frame piece when applied. The coupling section has a quadratic or rectangular cross-section and has at least one transversally extending threaded borehole. The four planes of the coupling section are parallel to the vertical plane and the horizontal plane of the control box.