Patents by Inventor Michael Schelle

Michael Schelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260022359
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.
    Type: Application
    Filed: September 29, 2025
    Publication date: January 22, 2026
    Inventors: David Rabuka, Allison Sharrar, Michael Schelle, Luisa Mayumi Arake de Tacca
  • Publication number: 20260015598
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-250 and at least one gRNA for target nucleic acid modification.
    Type: Application
    Filed: June 9, 2023
    Publication date: January 15, 2026
    Inventors: David Rabuka, Michael Schelle, Allison Sharrar
  • Patent number: 12385025
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.
    Type: Grant
    Filed: February 18, 2025
    Date of Patent: August 12, 2025
    Assignee: ACRIGEN BIOSCIENCES
    Inventors: David Rabuka, Allison Sharrar, Michael Schelle, Luisa Mayumi Arake de Tacca
  • Publication number: 20250179456
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.
    Type: Application
    Filed: February 18, 2025
    Publication date: June 5, 2025
    Inventors: David Rabuka, Allison Sharrar, Michael Schelle, Luisa Mayumi Arake de Tacca
  • Publication number: 20250179455
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.
    Type: Application
    Filed: February 18, 2025
    Publication date: June 5, 2025
    Inventors: David Rabuka, Allison Sharrar, Michael Schelle, Luisa Mayumi Arake de Tacca
  • Publication number: 20240392272
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.
    Type: Application
    Filed: September 28, 2022
    Publication date: November 28, 2024
    Inventors: David Rabuka, Allison Sharrar, Michael Schelle, Luisa Mayumi Arake de Tacca
  • Publication number: 20240309349
    Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity, at least 80% identity, at least 90% identity, at least 95% identity or at least 99% identity to any of SEQ ID NOs: 1-23 or 32-35 and at least one gRNA.
    Type: Application
    Filed: July 8, 2022
    Publication date: September 19, 2024
    Inventors: David Rabuka, Allison Sharrar, Michael Schelle, Luisa Mayumi Arake De Tacca, Mia Christina Pulos-Holmes
  • Publication number: 20230374502
    Abstract: Provided are compositions and methods that utilize Acr proteins with CRISPR Cas proteins to achieve a balance in which Cas proteins retain activity to perform on-target nucleic acid targeting functions (e.g., DNA cleavage for gene editing applications), but are inhibited by one or more Acr proteins to a degree that decreases off-target activity—thus resulting in an increased ratio of on-target to off-target nucleic acid targeting events. For example, provided is a system that includes one or more nucleic acids that comprise: a first nucleotide sequence encoding a Cas effector protein and a second nucleotide sequence encoding an Acr protein, wherein the first, second or both nucleotide sequences are operably linked to a translational control element.
    Type: Application
    Filed: September 30, 2021
    Publication date: November 23, 2023
    Inventors: David Rabuka, Michael Schelle, Luisa Mayumi Arake de Tacca
  • Patent number: 11785960
    Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: October 17, 2023
    Assignee: Ripple Foods, PBC
    Inventors: Lance Kizer, Neil Renninger, Michael Schelle
  • Publication number: 20230125846
    Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.
    Type: Application
    Filed: December 22, 2022
    Publication date: April 27, 2023
    Applicant: Ripple Foods, PBC
    Inventors: Lance Kizer, Neil Renninger, Michael Schelle
  • Patent number: 11571002
    Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: February 7, 2023
    Assignee: Ripple Foods, PBC
    Inventors: Lance Kizer, Neil Renninger, Michael Schelle
  • Publication number: 20200323231
    Abstract: Non-dairy cheese analogs and/or semi-soft non-dairy analogs that are derived substantially from or wholly from non-animal sources and have, among other things, improved cohesiveness, compressibility characteristics and/or rupture characteristics. Certain exemplary embodiments are directed to formulations that may be used to produce non-dairy analogs as well as non-dairy cheese analogs comprising high acyl gellan gum. Also provided are processes for production of such non-dairy cheese analogs and formulations.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 15, 2020
    Applicant: Ripple Foods, PBC
    Inventors: Michael SCHELLE, Sutton COWPERTHWAITE, Lance KIZER, Neil RENNINGER
  • Publication number: 20190142024
    Abstract: Provided are non-dairy yogurt analogs that have qualities similar to those of dairy-based yogurts. Certain embodiments are to plant-based yogurt analogs comprising fermented plant protein isolates and/or gelled plant protein isolates. Also provided are processes for production of such non-dairy yogurt analogs. For instance, a method for producing a plant-based yogurt mixture capable of being used to make a plant-based yogurt analog comprising the steps of: a) obtaining an essentially dairy-free base for a yogurt formulation that includes a plant-based derivative, such as a paste; and b) adding an acid to said formulation.
    Type: Application
    Filed: April 24, 2017
    Publication date: May 16, 2019
    Inventors: Lance Kizer, Neil Renninger, Michael Schelle
  • Patent number: 9828591
    Abstract: Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and Trichoderma host cells having a modification comprising or consisting essentially of disruption or deletion of nucleotide(s) for expression of this cellulose, whereby EGV expression is prevented.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: November 28, 2017
    Assignee: DANISCO US INC
    Inventors: Andrei Miasnikov, Michael Schelle, Michael Ward
  • Publication number: 20160040144
    Abstract: Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and Trichoderma host cells having a modification comprising or consisting essentially of disruption or deletion of nucleotide(s) for expression of this cellulose, whereby EGV expression is prevented.
    Type: Application
    Filed: August 20, 2015
    Publication date: February 11, 2016
    Applicant: DANISCO US INC.
    Inventors: Andrei Miasnikov, Michael Schelle, Michael Ward
  • Publication number: 20150057434
    Abstract: The invention relates to a recovery and/or purification process of hydrophobins involving organic solvents and does not require separation techniques. In particular, the invention relates to a method for selective alcohol precipitation of hydrophobin II.
    Type: Application
    Filed: April 16, 2012
    Publication date: February 26, 2015
    Applicant: DANISCO US INC.
    Inventor: Michael Schelle
  • Publication number: 20120107872
    Abstract: Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and Trichoderma host cells having a modification comprising or consisting essentially of disruption or deletion of nucleotide(s) for expression of this cellulose, whereby EGV expression is prevented.
    Type: Application
    Filed: October 19, 2011
    Publication date: May 3, 2012
    Inventors: Andrei Miasnikov, Michael Schelle, Michael Ward