Abstract: Methods and apparatus of some aspects of the invention relate to the synthesis of high fidelity polynucleotides. In particular, aspects of the invention relate to concurrent enzymatic removal of amplification sequences and ligation of processed oligonucleotides into nucleic acid assemblies. According to some embodiments, the invention provides a method for producing a target nucleic acid having a predefined sequence. In some embodiments, the method comprises the step of providing a plurality of oligonucleotides, wherein each oligonucleotides comprises (i) an internal sequence identical to a different portion of a sequence of a target nucleic acid, (ii) a 5? sequence flanking the 5? end of the internal sequence and a 3? flanking sequence flanking the 3? end of the internal sequence, each of the flanking sequence comprising a primer recognition site for a primer pair and a restriction enzyme recognition site.

Abstract: The present disclosure provides methods, devices, and systems for the butt welding of two, e.g., planar, workpieces composed of glass, e.g., quartz glass, by a pulsed laser beam, e.g., an ultrashort pulse (“USP”) laser beam, which is directed into the workpiece material parallel to the joining surface of the two workpieces and which is focused into the workpiece material in the region of the joining surface to locally melt the two workpieces in the region of their joining surface, wherein the laser focus of the laser beam focused into the workpiece material is moved in or counter to the beam direction of the laser beam to produce in the region of the joining surface a weld seam extending along the beam direction.

Abstract: Described is a process for the refinement of a quartz powder, comprising the step of separating microparticles of refractory minerals, in particular minerals containing rare earth metal compounds, from the quartz powder by an elutriation step.

Abstract: The present invention relates to specific compounds for use in the prevention or treatment of viral infections caused by RNA viruses.

Abstract: A system for transferring parcels made in accordance with the present invention includes: a first conveyor for conveying a bulk flow of parcels; a second conveyor positioned adjacent to the first conveyor; a robot positioned adjacent to the first conveyor and the second conveyor; and a rejection member. The robot engages and transfers select parcels in the bulk flow of parcels on the first conveyor to the second conveyor. The rejection member is positioned as to receive parcels offloaded from the first conveyor and/or the second conveyor and directs such parcels out of the system. Parcels within the bulk flow of parcels with characteristics which make it difficult for one or more of the components of the system or downstream systems to handle or process can be directed to the rejection member by operation of the first conveyor and/or the second conveyor to reduce system processing delays and stoppages.

Abstract: The present invention relates to MEK inhibitors for use in a method for the treatment of a coronavirus infection and/or the treatment or prevention of COVID-19 cytokine storm. Also provided are compositions comprising such inhibitors for use in the treatment of a corona virus infection, such as COVID-19.

Abstract: The present invention relates to a novel agent for the prophylactic and therapeutic treatment of a coronavirus infection and/or a disease caused by said infection, a pharmaceutical composition containing said agent, and a method for the prophylactic and/or therapeutic treatment of a coronavirus infection and/or a disease caused by said infection.

Abstract: The present invention relates to new peptides the amino acid sequences of which are derived from HD-5, for use in the treatment and/or prevention of Herpesviridae infections, in particular for treating and/or preventing a Betaherpesviridae infection, such as a HCMV-infection.

Abstract: The present invention relates to a cytotoxic agent for the prophylaxis and/or treatment of a viral infection which is configured for the selective binding to a membrane receptor of virus-infected T lymphocytes, a pharmaceutical composition containing said cytotoxic agent, the use of the cytotoxic agent for the prophylaxis and/or treatment of viral infections, a method of finding cytotoxic agents, the use of a membrane receptor of virus-infected T lymphocytes which is overexpressed in comparison to non-infected T lymphocytes for the diagnosis of a viral infection.

Abstract: A circuit arrangement for deactivating an occupant protection device is indicated, comprising a first switch having a first ohmic resistor connected in series with the first switch. The first ohmic resistor together with the first switch and a second ohmic resistor lying parallel to both form a first parallel connection. The circuit arrangement includes a second switch having a third ohmic resistor connected in series with the second switch. The third ohmic resistor together with the second switch and a fourth ohmic resistor lying parallel to both form a second parallel connection, the first parallel connection and the second parallel connection are connected in series with one another. A resistance value of the first ohmic resistor is greater than the resistance value of the third ohmic resistor, and a resistance value of the second ohmic resistor is greater than the resistance value of the first ohmic resistor.

Abstract: The present invention relates to a cytotoxic agent for the prophylaxis and/or treatment of a viral infection which is configured for the selective binding to a membrane receptor of virus-infected T lymphocytes, a pharmaceutical composition containing said cytotoxic agent, the use of the cytotoxic agent for the prophylaxis and/or treatment of viral infections, a method of finding cytotoxic agents, the use of a membrane receptor of virus-infected T lymphocytes which is overexpressed in comparison to non-infected T lymphocytes for the diagnosis of a viral infection.

Abstract: Described is a process for the refinement of a quartz powder, comprising the step of separating microparticles of refractory minerals, in particular minerals containing rare earth metal compounds, from the quartz powder by an elutriation step.

Abstract: A circuit arrangement for deactivating an occupant protection device is indicated, comprising a first switch having a first ohmic resistor connected in series with the first switch. The first ohmic resistor together with the first switch and a second ohmic resistor lying parallel to both form a first parallel connection. The circuit arrangement includes a second switch having a third ohmic resistor connected in series with the second switch. The third ohmic resistor together with the second switch and a fourth ohmic resistor lying parallel to both form a second parallel connection, the first parallel connection and the second parallel connection are connected in series with one another. A resistance value of the first ohmic resistor is greater than the resistance value of the third ohmic resistor, and a resistance value of the second ohmic resistor is greater than the resistance value of the first ohmic resistor.

Abstract: The present invention relates to a cytotoxic agent for the prophylaxis and/or treatment of a viral infection which is configured for the selective binding to a membrane receptor of virus-infected T lymphocytes, a pharmaceutical composition containing said cytotoxic agent, the use of the cytotoxic agent for the prophylaxis and/or treatment of viral infections, a method of finding cytotoxic agents, the use of a membrane receptor of virus-infected T lymphocytes which is overexpressed in comparison to non-infected T lymphocytes for the diagnosis of a viral infection.

Abstract: A method of separating heavy mineral particles, such as zircon, monazites, xenotime etc., from a sample of quartz crystal powder, comprises the steps of: a. conditioning the quartz powder suspected of containing heavy mineral particles as an aqueous pulp using a froth-flotation agent; b. subjecting the conditioned pulp to froth flotation to obtain a tailing; c. combining the tailing with an aqueous solution having a density greater than that of quartz and less than that of a heavy mineral which it is desired to separate; and d. centrifuging the combination. The separated heavy mineral crystals can then be characterized using a micro-analysis technique.

Abstract: A method of constructing a carrier for bottles (such as two or four craft beer bottles), wherein the layout fits through a digital printer, is disclosed. A flat of beverage board is printed upon (on one side or both, though all exterior surfaces are derived from one side of the board) with individualized and/or short-run graphics. The flat is die-cut and folded into a square or rectangle closed by a tab that is glued on the back of one of side panels, and bottom flaps are folded and glued into place. A riser extends up from each of a pair of opposite sides to support a handle flap, and the handle flaps are glued together across the top of the rectangle.

Abstract: A method of constructing a carrier for bottles (such as two or four craft beer bottles), wherein the layout fits through a digital printer, is disclosed. A flat of beverage board is printed upon (on one side or both, though all exterior surfaces are derived from one side of the board) with individualized and/or short-run graphics. The flat is die-cut and folded into a square or rectangle closed by a tab that is glued on the back of one of side panels, and bottom flaps are folded and glued into place. A riser extends up from each of a pair of opposite sides to support a handle flap, and the handle flaps are glued together across the top of the rectangle.

Abstract: A method of separating heavy mineral particles, such as zircon, monazites, xeno time etc., from a sample of quartz crystal powder, comprises the steps of: a. conditioning the quartz powder suspected of containing heavy mineral particles as an aqueous pulp using a froth-flotation agent; b. subjecting the conditioned pulp to froth flotation to obtain a tailing; c. combining the tailing with an aqueous solution having a density greater than that of quartz and less than that of a heavy mineral which it is desired to separate; and d. centrifuging the combination. The separated heavy mineral crystals can then be characterised using a micro-analysis technique.

Abstract: The present invention relates to the use of the ALS inhibitor herbicides for controlling unwanted vegetation in ALS inhibitor herbicide tolerant Brassica plants, more especially, the present invention relates to the use of ALS inhibitor herbicides for control of unwanted vegetation in Brassica growing areas which Brassica plants comprise non-transgenic mutations of their endogenous acetolactate synthase (ALS) genes I and III.

Abstract: Bicyclic (thio)carbonylamidines of the formula (I) in which Q, B, Y, R1 and A are as defined in the description their preparation and their use for controlling plant pests and pests encountered in veterinary medicine.