Abstract: Systems and methods for assembling structural components are disclosed wherein a selectively configurable fixture is placed on an assembly surface of an assembly table. An assembly table interface couples about a pin of a pin slot of the assembly table and, by means of linkage assembly, translates movement of the pin to a positioning member. The positioning member, by the translated movement of the pin, abuts an element of structural component and supports the element while a fastener is applied to join multiple elements of the structural component. A selectively configurable fixture may be used in isolation, or in combination with other fixtures.

Abstract: This disclosure provides methods and systems useful in array-based analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies). The disclosure also provides methods and systems useful in the diagnosis of genetic abnormalities in a mixed nucleic acid population taken non-invasively from an organism, such as a sample of blood, plasma, serum, urine stool or saliva. The disclosed methods and systems find use in multiple applications, including prenatal testing and cancer diagnostics. The disclosure is based on the hybridisation of amplified fragments from the sample, e.g. a maternal sample, which may employ molecular inversion probes MIP to an oligonucleotide array and the detection of the alleles based on different signals from the different alleles of the SNP.

Abstract: There is disclosed a polymer-based foam composition comprising a polymer and up to 20 M.-% particles of one or more inorganic particulate materials, based on the total weight of the composition, wherein the one or more inorganic particulate materials comprise less than 20 wt.-% Al, calculated as Al2O3-content. According to one aspect, the one or more inorganic particulate materials comprise phyllosilicates. Also part of the present invention is the use of such polymer-based foam compositions and their method of production.

Abstract: Systems and methods of epidemiological modeling using machine learning are provided, and can include receiving values for an occurrence of the infectious disease during a first time period, generating, from a model trained by a machine learning system, predictions for the occurrence of the infectious disease over a second time period, performing, by a simulator using the predictions, one or more simulations of the occurrence of the infectious disease in one or more geographic regions during one or more time periods subsequent to the second time period, and providing, to a user interface, a first simulation of the one or more simulations performed by the simulator for a first geographic region of the one or more geographic regions during a time period of the one or more time periods.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: A method and apparatus of processing a user initiated request for information is disclosed. The method may provide receiving a user initiated request including a uniform resource locator (URL) submitted to a web browser application and receiving a response that the URL is an invalid URL that cannot be resolved to a corresponding webpage. The method may also include blocking a subsequent attempt to transmit the user initiated request as a browser modified search request that includes modifications to the user initiated request.

Abstract: Aspects of this invention inter alia relate to novel systems for targeting, editing or manipulating DNA in a cell, comprising one or more heterologous vector(s) encoding a SluCas9 nuclease from Staphylococcus lugdunensis or variants thereof, and one or more guide RNAs (gRNAs), or a SluCas9 nuclease or variant thereof and one or more gRNAs.

Abstract: A visual-programming tool processes nodes of a graph corresponding to operations or functions in program code associated with a plurality of programs, (e.g., games), stored as graph of nodes with logical connections signifying inputs, outputs, and/or units of connected nodes. The visual-programming tool resolves valid types and/or units associated with respective connected nodes and can propagate valid types and/or units throughout the graph.

Abstract: A power machine can include operator input devices and a control system configured to command movement of actuators based on operator inputs received from the operator input devices. Movement of one or more of the actuators can be commanded based on input at one or more of the operator input devices and a response curve selected from a plurality of different response curves. Movement of one or more of the actuators can be based on a selected control mode for the power machine that corresponds to a selected control-function mapping of the operator input devices to the one or more actuators. A lift arm can be variously controlled to execute automatic or other operations. An excavator can be operated in a sustained-speed travel mode. Actuation of a bucket or other implement can be implemented based on signals from a material sensor.

Abstract: Process for making a granule containing (A) at least one chelating agent selected from alkali metal salts of methyl glycine diacetic acid (MGDA) and of iminodisuccinic acid (IDS), and, optionally, (B) at least one homo- or copolymer of (meth)acrylic acid, partially or fully neutralized with alkali, said process comprising the steps of (a) providing an aqueous solution or slurry containing chelating agent (A) and, if applicable, (co)polymer (B), (b) removing most of said water by spray granulation in a fluidized bed, (c) treating the resultant granule in a vessel of which at least one part rotates around a horizontal axis and wherein said vessel is selected from paddle mixers, free-fall mixers and plough share mixers.

Abstract: An adapter for a bike mount including a coupling plate, a first adapter section coupled to the coupling plate, and a second adapter section coupled to the coupling plate. The first adapter section is configured to receive a first bike axle. The second adapter section is configured to receive a second bike axle different than the first bike axle.

Abstract: An apparatus includes a support, including an outer surface and configured for insertion into a body of a subject. The apparatus further includes multiple atoms of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer of a polymer, which covers the atoms so as to protect the atoms from being washed away, yet allows diffusion of the daughter radionuclide through the layer. Other embodiments are also described.

Abstract: Apparatus and associated methods relate to presenting for selection, services comprising at least one bundled set of healthcare services to be performed separately by respective providers, determining a bundle price for the at least one bundled set of healthcare services and in response to receiving payment in an amount of the bundle price, generating a persistent purchase data record with a unique confirmation number that is selectively redeemable by the user to receive each of the healthcare services in the bundled set. The bundle price may be discounted and/or based on the location or time at which at least one service will be performed. The bundle price may also be based on the user's remaining health insurance deductible. A single payment may be disbursed to multiple providers of the bundled set of healthcare services. The received and/or disbursed payment may be in virtual funds.

Abstract: This disclosure provides methods and kits useful in analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications, and aneuploidies). The disclosure also provides methods and systems useful in the diagnosis of genetic abnormalities in a mixed nucleic acid population taken non-invasively from an organism, such as a sample of blood, plasma, serum, urine stool or saliva. The disclosed methods and systems find use in multiple applications, including prenatal testing and cancer diagnostics. The method is based on the hybridization of amplified fragments obtained from the sample, e.g., using molecular inversion probes (MIP) to an oligonucleotide array and the detection of the alleles based on different signals from the different alleles of the SNP.

Abstract: The invention relates to a method for selectively configuring a container that contains an application, wherein user-authentication data are received by a container management component and forwarded via a container applicant to an authorisation server. This server transmits an authorisation response, on the basis of which a decision is made as to whether the application is allowed to be run in the container.

Abstract: The present invention relates to radiolabeled compounds of formula I wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, 11C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.

Abstract: A power machine can include operator input devices and a control system configured to command movement of actuators based on operator inputs received from the operator input devices. Movement of one or more of the actuators can be commanded based on input at one or more of the operator input devices and a response curve selected from a plurality of different response curves. Movement of one or more of the actuators can be based on a selected control mode for the power machine that corresponds to a selected control-function mapping of the operator input devices to the one or more actuators. A lift arm can be variously controlled to execute automatic or other operations. An excavator can be operated in a sustained-speed travel mode.

Abstract: A method is for providing an aggregate algorithm for processing medical data. In an embodiment, a multitude of local algorithms are trained by machine learning. The training of each respective local algorithm is performed on a respective local system using respective local training data. A respective algorithm dataset concerning the respective local algorithm is transferred to an aggregating system that generates the aggregate algorithm based on the algorithm datasets.

Abstract: An inhaler vaporizer cartridge includes a housing body with a flow channel, a liquid storage tank, and a vaporizer unit. The vaporizer unit has a wick member and heating member and is liquid-permeable such that liquid is conveyed from the tank through the vaporizer unit to the flow channel. The housing body has a cavity forming the tank and a wick member receiving chamber, and housing is divided by an intermediate wall and a flow channel section. An access opening from the receiving chamber to the flow channel is formed in the intermediate wall and covered by the heating member. Granular grains in the receiving chamber form the wick member and bear against the heating member. The grains form microchannels and are retained by a cover element. An access opening, covered with a liquid-permeable grid structure, establishes a liquid connection from the tank to receiving chamber in the intermediate wall.

Abstract: Described embodiments include an apparatus (20, 21), which includes a support (22), including an outer surface (24) and configured for insertion into a body of a subject. The apparatus further includes multiple atoms (26) of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer (28, 33) of a polymer, which is permeable to the daughter radionuclide, that covers the atoms. Other embodiments are also described.