Abstract: The present disclosure provides a magnetic multi-turn sensor comprising a continuous coil of magnetoresistive elements and a method of manufacturing said sensor. The continuous coil is formed on a substrate such as a silicon wafer that has been fabricated so as to form a trench and bridge arrangement that enables the inner and outer spiral to be connected without interfering with the magnetoresistive elements of the spiral winding in between. Once the substrate has been fabricated with the trench and bridge arrangement, a film of the magnetoresistive material can be deposited to form a continuous coil on the surface of the substrate, wherein a portion of the coil is formed in the trench and a portion of the coil is formed on the bridge.

Abstract: In one implementation, a computer-implemented method includes receiving, at a computer system, information that indicates that a fire has been detected in a building and that a fire suppression system within the building has begun dousing the fire; monitoring sensor information from one or more sensors located within the building; determining, by the computer system and based on the sensor information, whether the fire has been extinguished; activating, in response to determining that the fire has been extinguished, a feature to turn off a water supply to the building, the feature being presented on a computing device for a user who is associated with the building; receiving, after activating the feature and from the computing device, a command to turn off the water supply; and transmitting, by the computer system, a control signal that causes an electromechanical device to close a water valve within the building.

Abstract: Aspects of this disclosure relate to one or more particles that move within a container in response to a magnetic field. A measurement circuit is configured to output an indication of the magnetic field based on position of the one or more particles.

Abstract: A composition contains n-heptyl-glyceryl ether and at least one further carefully chosen and synergistically active preservative.

Abstract: Aspects of this disclosure relate to particles that can move in response to a magnetic field. A system can include a container, particles within the container, and a magnetic structure integrated with the container. The magnetic structure can magnetically interact with both an external magnetic field and the particles. Related methods are disclosed including magnetic field detection methods based on detection of particles within a container.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.

Abstract: Raw sensor data from a device of a user is collected. The raw data does not include location data for the device. The data is preprocessed to identify driving trips in which the user had the device. The trip data is provided to machine-learning models (MLMs) as input and the MLMs provide as output predictions for each trip's estimated speeds, estimated number of hard brakes and a degree of each hard brake, and estimated degrees of distracted driving. A duration, time of day, and calendar date of each trip is identified. The predictions, duration, time of day, and calendar date are modified into four factor values. The four modified factor values are combined into an overall driver characteristic value and provided to a network service associated with the user for purposes of providing or modifying services provided to the user through the network service based on the overall characteristic value.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.

Abstract: An electrical stimulation training and neuromuscular rehabilitation system including a machine-washable stimulation suit with multiple electrodes to provide controlled stimulation of various muscle groups is provided. The stimulation suit may also include one or more integrated biosensors to provide diagnostic capability in addition to stimulation. The system may also include a software platform executable on a user computing device (such as a tablet) that may facilitate control of the stimulation programs (e.g., intensity level, duration, isolation of individual muscle groups vs. full body stimulation) of one or more stimulation suits by the wearer or a fitness practitioner or trainer and/or that may facilitate intervention by a medical provider through a remote telemedicine platform.

Abstract: In some examples, a roll unwinder for a flying roll change includes a roll station for receiving a first material roll to be unwound, and a roll station for receiving a second material roll to be unwound after a roll change has occurred. A cut-off tool can sever a first web unwound from the first material roll, and includes a pressing element, to press the web against the outer surface of the second material roll. A supporting device can be transferred from an idle state into a working state in which the supporting device supports the web to be unwound, at least at the time of the severing process. The supporting device supports the web in a web path upstream from the cut-off tool. A receiving unit at a frame that carries the cut-off tool is movably mounted in the stand of the roll unwinder.

Abstract: The present invention relates to a process for the production of 2,2,4,6,6-pentamethyl-1,2,5,6-tetrahydro-pyrimidine comprising (i) providing a reactor containing a catalyst comprising a zeolitic material, wherein the zeolitic material comprises YO2 and optionally comprises X2O3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element; (ii) preparing a reaction mixture comprising acetone and ammonia; (iii) contacting the catalyst in the reactor with the reaction mixture prepared in (ii) for obtaining a reaction product comprising 2,2,4,6,6-pentamethyl-1,2,5,6-tetrahydro-pyrimidine; wherein the temperature programmed desorption of ammonia (NH3-TPD) profile of the zeolitic material comprised in the catalyst provided in (i) optionally displays one or more bands associated with medium acid sites, said one or more bands having maxima in the temperature range of from 250 to 500° C., wherein the integration of said one or more bands affords a total value of 0.

Abstract: A predictive model is described that can predict parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can be used to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.

Abstract: This invention relates methods of using a non-fucosylated anti-CD40 antibody for treatment of uveal melanoma.

Abstract: An electrical stimulation training and neuromuscular rehabilitation system including a machine-washable stimulation suit with multiple electrodes to provide controlled stimulation of various muscle groups is provided. The stimulation suit may also include one or more integrated biosensors to provide diagnostic capability in addition to stimulation. The system may also include a software platform executable on a user computing device (such as a tablet) that may facilitate control of the stimulation programs (e.g., intensity level, duration, isolation of individual muscle groups vs. full body stimulation) of one or more stimulation suits by the wearer or a fitness practitioner or trainer and/or that may facilitate intervention by a medical provider through a remote telemedicine platform.

Abstract: This disclosure relates to methods of treating cancer using a combination of an anti-CD40 antibody such as SEA-CD40, and an anti-PD-1 antibody such as pembrolizumab. The treatment can further include a chemotherapy.

Abstract: In some examples, a roll unwinder for a flying roll change includes a roll station for receiving a first material roll to be unwound, and a roll station for receiving a second material roll to be unwound after a roll change has occurred. A cut-off tool can sever a first web unwound from the first material roll, and includes a pressing element, to press the web against the outer surface of the second material roll. A supporting device can be transferred from an idle state into a working state in which the supporting device supports the web to be unwound, at least at the time of the severing process. The supporting device supports the web in a web path upstream from the cut-off tool. A receiving unit at a frame that carries the cut-off tool is movably mounted in the stand of the roll unwinder.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.

Abstract: A predictive model is described that can predict parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can be used to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.

Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.