Abstract: A device for accurately guiding and positioning a surgical instrument bearing suture material to a predetermined area within the body for closing an open wound includes an elongated conically shaped guide that is wider at the top and which has two openings in the side wall thereof. The top has two openings that communicate with the openings in the side wall through generally linear passageways that pass through the guide and which allow surgical instruments carrying suture material to pass therethrough. A thin elongated rod extends upwardly from the top wall approximately two inches and includes a handle at the top thereof. Raising the handle above the guide increases the field of view of the surgeon.

Abstract: The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.

Abstract: A device for accurately guiding and positioning a surgical instrument bearing suture material to a predetermined area within the body for closing an open wound includes an elongated conically shaped guide that is wider at the top and which has two openings in the side wall thereof. The top has two openings that communicate with the openings in the side wall through generally linear passageways that pass through the guide and which allow surgical instruments carrying suture material to pass therethrough. A thin elongated rod extends upwardly from the top wall approximately two inches and includes a handle at the top thereof. Raising the handle above the guide increases the field of view of the surgeon.

Abstract: The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.

Abstract: The invention relates to an adjustment device for a valve pin on an injection molding machine, and particularly on a multi-cavity machine, having a plurality of valve pins mounted on a common yoke plate which is actuated by a common actuator. The adjustment device includes a pin holder for holding the valve pin, and a locking member. The pin holder has two threaded portions. The first threaded portion is adjustable within a threaded receiving hole in the yoke plate. The second threaded portion is received by the locking member. The locking member has a bottom shoulder which butts against the yoke plate, and retains the pin holder in place.

Abstract: The invention relates to an adjustment device for a valve pin on an injection molding machine, and particularly on a multi-cavity machine, having a plurality of valve pins mounted on a common yoke plate which is actuated by a common actuator. The adjustment device includes a pin holder for holding the valve pin, and a locking member. The pin holder has two threaded portions. The first threaded portion is adjustable within a threaded receiving hole in the yoke plate. The second threaded portion is received by the locking member. The locking member has a bottom shoulder which butts against the yoke plate, and retains the pin holder in place.