Abstract: Disclosed are various embodiments for managing which location-based service zones to monitor within a geographic region. An active zone defining a geographic region and location-based service zones within the geographic region is provided by another computing device. The selection of a subset of the location-based service zones to monitor within an active zone can be based on an estimated current device location and/or other parameters.

Abstract: Disclosed are various embodiments for managing location-based service zones being monitored by a client device. The location-based service zones within a geographic region can be organized in location-based service zone clusters. In response to receiving an active zone from a computing device, a client device can begin monitoring the geographic parameters for the top-level location-based service zone clusters. When the client device detects an entry into a particular location-based service zone cluster, the client device stops monitoring the top-level location-based service zone clusters and begins monitoring the location-based service zones that are within the particular location-based service zone cluster.

Abstract: Disclosed are various embodiments for managing which location-based service zones to monitor within a geographic region. An active zone defining a geographic region and location-based service zones within the geographic region is provided by another computing device. The selection of a subset of the location-based service zones to monitor within an active zone can be based on an estimated current device location and/or other parameters.

Abstract: Disclosed are various embodiments for managing which location-based service zones to monitor when the number location-based service zones within a geographic region exceed the amount the device can support. An active zone defining a geographic region and location-based service zones within the geographic region is provided by another computing device. When the number of location-based service zones meets or exceeds a predefined threshold, a subset of the location-based service zones is selected for monitoring according to a current device location and/or other parameters.

Abstract: Disclosed are various embodiments for managing which location-based service zones to monitor when the number location-based service zones within a geographic region exceed the amount the device can support. An active zone defining a geographic region and location-based service zones within the geographic region is provided by another computing device. When the number of location-based service zones meets or exceeds a predefined threshold, a subset of the location-based service zones is selected for monitoring according to a current device location and/or other parameters.

Abstract: Disclosed are various embodiments for managing which location-based service zones to monitor when the number location-based service zones within a geographic region exceed the amount the device can support. An active zone defining a geographic region and location-based service zones within the geographic region is provided by another computing device. When the number of location-based service zones meets or exceeds a predefined threshold, a subset of the location-based service zones is selected for monitoring according to a current device location and/or other parameters.

Abstract: Cardiac implants include a conduit or scaffold having a first therapeutic agent in at least partial covering relation to at least a first portion of the scaffold, and a second therapeutic agent, different from the first therapeutic agent, in at least partial covering relation to at least a second portion of the scaffold. The first therapeutic agent and second therapeutic agent may include one of: antithrombotic agents, anti-inflammatory agents, antiproliferative agents, antibiotic agents, angiogenic agents, antiplatelet agents, anticoagulant agents, rhestenosis preventing agents, hormones and combinations thereof. Methods for making cardiac implants include providing a scaffold, covering at least a first portion of the scaffold with a first therapeutic agent, and covering at least a second portion of the scaffold, different from the first portion, with a second therapeutic agent different from the first therapeutic agent.

Abstract: Cardiac implants include a conduit or scaffold having a first therapeutic agent in at least partial covering relation to at least a first portion of the scaffold, and a second therapeutic agent, different from the first therapeutic agent, in at least partial covering relation to at least a second portion of the scaffold. The first therapeutic agent and second therapeutic agent may include one of: antithrombotic agents, anti-inflammatory agents, antiproliferative agents, antibiotic agents, angiogenic agents, antiplatelet agents, anticoagulant agents, rhestenosis preventing agents, hormones and combinations thereof. Methods for making cardiac implants include providing a scaffold, covering at least a first portion of the scaffold with a first therapeutic agent, and covering at least a second portion of the scaffold, different from the first portion, with a second therapeutic agent different from the first therapeutic agent.

Abstract: A transmyocardial implant includes a hollow rigid conduit having a vessel portion and a myocardial portion. The vessel portion is sized to be inserted into a blood vessel segment taken from a non-coronary artery or vein. The myocardial portion is sized to extend from the vessel portion and through a myocardium into a heart chamber. The conduit has open vessel and myocardial ends on respective ends of the vessel and myocardial portions to define a blood flow pathway within an interior of the conduit between the vessel and myocardial ends. The myocardial portion is formed of a conduit material sufficiently rigid to resist deformation and closure of the pathway in response to contraction of the myocardium. The vessel portion has a radial compliance approximating a radial compliance of the vessel.

Abstract: Cardiac implants include a conduit or scaffold having a first therapeutic agent in at least partial covering relation to at least a first portion of the scaffold, and a second therapeutic agent, different from the first therapeutic agent, in at least partial covering relation to at least a second portion of the scaffold. The first therapeutic agent and second therapeutic agent may include one of: antithrombotic agents, anti-inflammatory agents, antiproliferative agents, antibiotic agents, angiogenic agents, antiplatelet agents, anticoagulant agents, rhestenosis preventing agents, hormones and combinations thereof. Methods for making cardiac implants include providing a scaffold, covering at least a first portion of the scaffold with a first therapeutic agent, and covering at least a second portion of the scaffold, different from the first portion, with a second therapeutic agent different from the first therapeutic agent.