Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: Various embodiments are directed to systems and methods for tracking and managing compliance for a plurality of insurance policies on a plurality of properties or other collateral. Insurance, loan, and compliance information may be received and stored in a database. The database may be updated periodically based on new loan, insurance, and compliance information. Users may manage and track the changing compliance status of each loan and policy. Alerts may input, stored, and/or auto-generated to flag compliance issues. Communications such as compliance letters may be automatically generated according to a predetermined schedule based on compliance status. Supporting documents associated with compliance requirements may be stored and displayed to users to facilitate compliance tracking and management.

Abstract: Devices and methods disclosed herein can include a conductive foam having pores disposed within the conductive foam. The conductive foam can be compressible between an uncompressed thickness and a compressed thickness. The compressed thickness can be ninety-five percent or less of the uncompressed thickness. In one example, a filler can be disposed in the pores of the conductive foam. The filler can include a first thermal conductivity. The first thermal conductivity can be greater than a thermal conductivity of air.

Abstract: The present invention generally relates to the field of antimicrobial peptides (AMPs), and more specifically to cationic intrinsically disordered antimicrobial peptides (CIDAMPs) and their use as disinfectants and therapeutic agents for the treatment of infections, especially as a therapeutic alternative for the treatment of infectious diseases caused by antibiotic resistant microorganisms.

Abstract: Vulnerable code allows outside actors to interfere with the normal operation of current systems. To help defend against these outside actors, it is desirable to identify vulnerabilities in existing systems, including systems where the original source code is not available for study. Described herein are methods for identifying functional attributes that change the intended operation of a compiled binary extracted from a target system.

Abstract: Embodiments herein relate to systems, apparatuses, processing, and techniques related to may generally relate to a printed circuit board (PCB) with one or more strain gauges integrated into the PCB, where the strain gauges are to facilitate an evaluation of PCB integrity during operation of the PCB. The strain gauge may include discrete strain gauges integrated into the PCB at potentially critical stress points within the PCB. The strain gauge may include an electrically conductive daisy chain formation of solder bumps where a change in electrical resistance along the daisy chain formation indicates a strain on the PCB. The strain gauge may include one or more traces included in the PCB, where a change in electrical resistance along the one or more traces is to indicate a strain on the PCB.

Abstract: A belting connection for attaching a first end and a second end of belting. The belting has a thickness. The belting connection mechanism includes a first stepped region, a second stepped region and a first fastener. The first stepped region is proximate the first end. The first stepped region has a first aperture formed therein. The first stepped region has a first thickness. The second stepped region is proximate the second end. The second stepped region has a second aperture formed therein. The second stepped region has a second thickness. The first fastener extends through the first aperture and the second aperture to attach the first end to the second end. The first stepped region at least partially overlaps the second stepped region when the first end is attached to the second end. When the first end is attached to the second end, the first stepped region and the second stepped region have a combined thickness that is no greater than the thickness of the belting.

Abstract: Particular techniques involve a device for wetting multiple threads with a fluid, and a dosing pump which is connected to the wetting means by multiple conveying lines. The dosing pump has multiple conveying means for generating multiple dosing flows of the fluid and has multiple pump outlets, to which the delivery lines are connected. The conveying means are formed by at least one planetary gear set arranged between housing plates. To achieve, as far as possible, a uniform throughflow without a significant dead space volume, multiple planet gears of the planetary gear set are guided freely by a centering plate between adjacent housing plates. The planet gears of the planetary gear set have in each case one passage opening, which are connected by a channel system to a central pump inlet. It is thus possible to realize close fits and flushing of gaps.

Abstract: Vulnerable code allows outside actors to interfere with the normal operation of current systems. To help defend against these outside actors, it is desirable to identify vulnerabilities in existing systems, including systems where the original source code is not available for study. Described herein are methods for identifying functional attributes that change the intended operation of a compiled binary extracted from a target system.

Abstract: Vulnerable code allows outside actors to interfere with the normal operation of current systems. To help defend against these outside actors, it is desirable to identify vulnerabilities in existing systems, including systems where the original source code is not available for study. Described herein are methods for identifying functional attributes that change the intended operation of a compiled binary extracted from a target system.

Abstract: A belting connection for attaching a first end and a second end of belting. The belting has a thickness. The belting connection mechanism includes a first stepped region, a second stepped region and a first fastener. The first stepped region is proximate the first end. The first stepped region has a first aperture formed therein. The first stepped region has a first thickness. The second stepped region is proximate the second end. The second stepped region has a second aperture formed therein. The second stepped region has a second thickness. The first fastener extends through the first aperture and the second aperture to attach the first end to the second end. The first stepped region at least partially overlaps the second stepped region when the first end is attached to the second end. When the first end is attached to the second end, the first stepped region and the second stepped region have a combined thickness that is no greater than the thickness of the belting.

Abstract: A ski boot frame that is attachable to a soft shell snow boot, for example a snowboard boot, for downhill skiing. The ski boot frame is constructed of multiple rigid materials to provide a user with proper support for downhill skiing. The ski boot frame further includes adjustable toe clip and heel clips for attachment to a standard downhill ski binding. The toe and heel clips are preferably adjustable to fit the frame to a plurality of sizes of ski bindings. The ski boot frame further includes a calf support that provides for a progressive forward resistance critical for downhill skiing.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: A system, such as a security monitoring system, includes one or more devices at a physical space. Each device performs a function (e.g., security monitoring) at the physical space, and at least one is able to interact, via a network, with a mobile device. The system is automatically controlled based on a location of the mobile device. The system tracks the mobile device with a first tracking technique when located outside both a home region associated with the physical space and an active monitoring region that surrounds the home region, determines, based on the tracking information, whether the mobile device is within the active monitoring region, and switches to a second, different, tracking technique if it is determined that the mobile device is within the active monitoring region.

Abstract: Devices and methods disclosed herein can include a conductive foam having pores disposed within the conductive foam. The conductive foam can be compressible between an uncompressed thickness and a compressed thickness. The compressed thickness can be ninety-five percent or less of the uncompressed thickness. In one example, a filler can be disposed in the pores of the conductive foam. The filler can include a first thermal conductivity. The first thermal conductivity can be greater than a thermal conductivity of air.

Abstract: A system, such as a security monitoring system, includes one or more devices at a physical space. Each device performs a function (e.g., security monitoring) at the physical space, and at least one is able to interact, via a network, with a mobile device. The system is automatically controlled based on a location of the mobile device. The system tracks the mobile device with a first tracking technique when located outside both a home region associated with the physical space and an active monitoring region that surrounds the home region, determines, based on the tracking information, whether the mobile device is within the active monitoring region, and switches to a second, different, tracking technique if it is determined that the mobile device is within the active monitoring region.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP2.

Abstract: A ski boot frame that is attachable to a soft shell snow boot, for example a snowboard boot, for downhill skiing. The ski boot frame is constructed of multiple rigid materials to provide a user with proper support for downhill skiing. The ski boot frame further includes adjustable toe clip and heel clips for attachment to a standard downhill ski binding. The toe and heel clips are preferably adjustable to fit the frame to a plurality of sizes of ski bindings. The ski boot frame further includes a calf support that provides for a progressive forward resistance critical for downhill skiing.

Abstract: Embodiments disclosed herein include fiber optic cable crimp assemblies employing integrally connected cable strain relief boots to provide a single component crimp assembly. Related fiber optic connectors, cables, and methods are also disclosed. A fiber optic cable crimp assembly is employed for securing a fiber optic connector assembly to a fiber optic cable to form a terminated fiber optic connector. The fiber optic cable crimp assembly includes a cable strain relief boot configured to receive an end portion of a fiber optic cable to provide bend and strain relief for the end portion of the fiber optic cable. A fiber optic cable crimp band is integrally connected to the cable strain relief boot. The fiber optic crimp assembly is further configured to secure the end portion of the fiber optic cable to a fiber optic connector assembly.

Abstract: A tube conveyor belt system for use in conjunction with a support. At least a portion of the support has a concave shape. The tube conveyor belt system has a belt and at least one cleat. The belt has a surface. The at least one cleat extends from the surface of the belt. The at least one cleat includes a plurality of paddle regions and a plurality of web regions. The plurality of paddle regions is in a spaced-apart configuration. The web regions have a flexibility that is greater than a flexibility of the paddle regions. One of the web regions is positioned between adjacent paddle regions.