Patents by Inventor Michael Schwaebe

Michael Schwaebe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR SYNTHESIS OF CHK1 INHIBITORS
    Publication number: 20230150994
    Abstract: The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.
    Type: Application
    Filed: April 6, 2021
    Publication date: May 18, 2023
    Inventors: Michael SCHWAEBE, Thorsten ROSNER, Dalian ZHAO, Ross MILLER, Rich DULINA, Michael HUMORA, Stephen E. GOTTSCHLING
  • Quinolone analogs and methods related thereto
    Patent number: 8853234
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: October 7, 2014
    Assignee: Senhwa Biosciences, Inc.
    Inventors: Johnny Yasuo Nagasawa, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • Polymorphs and salts of a kinase inhibitor
    Patent number: 8853235
    Abstract: The present invention relates to novel crystalline polymorphic salt forms of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid, processes for the preparation thereof, compositions thereof and their use in methods of treatment and prevention of conditions mediated by casein kinase (CK) and/or poly(ADP-ribose)polymerase (PARP).
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: October 7, 2014
    Assignee: Senhwa Biosciences, Inc.
    Inventors: David M. Ryckman, Michael Schwaebe
  • SUBSTITUTED QUINOBENZOXAZINE ANALOGS
    Publication number: 20120122804
    Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 17, 2012
    Applicant: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terrance Moran
  • QUINOLONE ANALOGS AND METHODS RELATED THERETO
    Publication number: 20110218184
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 8, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Johnny Yasuo NAGASAWA, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • POLYMORPHS AND SALTS OF A KINASE INHIBITOR
    Publication number: 20110160240
    Abstract: The present invention relates to novel crystalline polymorphic salt forms of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid, processes for the preparation thereof, compositions thereof and their use in methods of treatment and prevention of conditions mediated by casein kinase (CK) and/or poly(ADP-ribose)polymerase (PARD).
    Type: Application
    Filed: November 23, 2010
    Publication date: June 30, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: David M. Ryckman, Michael Schwaebe
  • PYRIDINONE ANALOGS
    Publication number: 20110112086
    Abstract: The present invention provides pyridinone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing pyridinone analogs, and methods of using the same.
    Type: Application
    Filed: June 8, 2007
    Publication date: May 12, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Fabrice Pierre, Michael Schwaebe
  • Quinolone analogs and methods related thereto
    Patent number: 7928100
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: April 19, 2011
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Johnny Yasuo Nagasawa, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • HYDRAZIDE COMPOUNDS AND USES THEREOF
    Publication number: 20110065687
    Abstract: This application relates to certain novel polycyclic compounds that interact with quadruplex-forming regions of polynucleotides and thereby inhibit translation of genetic information into polypeptides. These compounds can thus provide anticancer and antibacterial and antiviral effects. The invention includes novel compounds and pharmaceutical compositions, and methods of using them to treat cancer and other conditions.
    Type: Application
    Filed: April 17, 2008
    Publication date: March 17, 2011
    Inventors: Michael Schwaebe, Johnny Yasuo Nagasawa, Mustapha Haddach
  • Methods of preparing quinolone analogs
    Patent number: 7834180
    Abstract: Compounds having formula 1: are produced by contacting a compound having formula (6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1, W, X, B?, R and n are as defined herein.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: November 16, 2010
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Johnny Y. Nagasawa, Michael Schwaebe, Fabrice Pierre
  • Quinolone analogs
    Patent number: 7816406
    Abstract: The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and methods of using the same.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: October 19, 2010
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Fabrice Pierre, Collin Regan, Michael Schwaebe, Johnny Y. Nagasawa, Peter Chua
  • Methods of preparing quinolone analogs
    Patent number: 7816524
    Abstract: Compounds having formula 1 are produced by contacting a compound having formula(6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1,W, X, B?, R and N are as defined herein.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: October 19, 2010
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Johnny Y. Nagasawa, Michael Schwaebe, Fabrice Pierre
  • TETRACYCLIC IMIDAZOLE ANALOGS
    Publication number: 20100063046
    Abstract: The present invention provides tetracyclic imidazole analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing these compounds, and methods of using the same.
    Type: Application
    Filed: May 17, 2007
    Publication date: March 11, 2010
    Inventors: Jeffrey P. Whitten, Michael Schwaebe
  • Methods for converting quinolone esters into quinolone amides
    Patent number: 7652134
    Abstract: The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a Lewis acid having formula MLn, wherein L is a halogen atom or an organic radical, n is 3-5, and M is a group III elemental atom, a group IV elemental atom, As, Sb, V or Fe, wherein A, B, V, X, Z, W, R1, R2, R5, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8 are substituents. Z4, Z5, Z6, Z7, and Z8 are substituents.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: January 26, 2010
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Fabrice Pierre, Collin Regan, Michael Schwaebe, George Petros Yiannikouros, Michael Jung
  • Substituted quinobenzoxazine analogs
    Patent number: 7612063
    Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: November 3, 2009
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terence Moran
  • QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF
    Publication number: 20090215761
    Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, L, R1, R3, R4 and R5 are substituents. The present invention also relates to methods for using such compounds.
    Type: Application
    Filed: June 30, 2008
    Publication date: August 27, 2009
    Applicant: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Fabrice Pierre, Michael Schwaebe
  • QUINOLONE ANALOGS AND METHODS RELATED THERETO
    Publication number: 20090093455
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 9, 2009
    Inventors: Johnny Yasuo NAGASAWA, Fabrice PIERRE, Mustapha HADDACH, Michael SCHWAEBE, Levan DARJANIA, Jeffrey P. WHITTEN
  • METHODS OF PREPARING QUINOLONE ANALOGS
    Publication number: 20090082565
    Abstract: The present invention relates to the preparation of compounds which are capable of inducing cell death such as apoptotic cell death (apoptosis), and/or for reducing a cell proliferative disorder.
    Type: Application
    Filed: November 19, 2008
    Publication date: March 26, 2009
    Applicant: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. CHUA, Johnny Y. Nagasawa, Michael Schwaebe, Fabrice Pierre
  • Substituted quinobenzoxazine analogs and methods of using thereof
    Patent number: 7507727
    Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein V, A, X, Z, W, U and R5 are substituents. The present invention also relates to methods for using such compounds, such as in screening and for inducing apoptosis.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: March 24, 2009
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terence Moran
  • SUBSTITUTED QUINOBENZOXAZINE ANALOGS
    Publication number: 20080261963
    Abstract: The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.
    Type: Application
    Filed: January 14, 2008
    Publication date: October 23, 2008
    Inventors: Jeffrey P. Whitten, Michael Schwaebe, Adam Siddiqui-Jain, Terence Moran