Abstract: The present disclosure relates to use of a protein kinase C (PKC) inhibitor in the treatment or prevention of proliferative diseases. The disclosure also relates to corresponding pharmaceutical formulations, uses, methods, combinations, and related disclosure embodiments. The disclosure further relates to use of a pharmaceutical combination comprising a PKC inhibitor and another therapeutic agent, such as an MDM2 inhibitor, in the treatment or prevention of a proliferative disease.

Abstract: Systems and processes for operating an intelligent automated assistant are provided. In one example process, a natural-language user input is received at an electronic device and a user intent determined. Where an audio recording corresponding to the intent is available, a digital assistant of the electronic device provides a first spoken output introducing the audio recording, the audio recording itself, and a second spoken output indicating the end of the audio recording.

Abstract: A fluid end assembly comprising a housing having multiple conduits formed therein. A tubular sleeve is installed within one of the conduits and is configured to house a plurality of packing seals. A seal is installed within a groove formed in the walls of the housing surrounding the tubular sleeve such that the seal engages an outer surface of the tubular sleeve.

Abstract: A diagnostic system for determining the presence of a target in a sample liquid that includes a diagnostic reader and a microfluidic strip having a microfluidic channel network therein. An actuator within the reader modifies the pressure of a gas in gaseous communication with a liquid-gas interface of a sample liquid within the microfluidic channel network to move and/or mix the sample liquid. The pressure modifications may be continuous and/or oscillatory.

Abstract: Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: A system cures and manufactures a partially-cured tire assembly. The system includes a plurality of elongate spacer members for maintaining corresponding a uniform cavity tension in the partially-cured tire assembly, each spacer member including a first longitudinal body member axially opposed to a second longitudinal body member, two cam bolts for adjusting a radial gap between the first longitudinal body member and the second longitudinal body member, and two springs each attached to the first body member and the second body member for maintaining a radial compressive force against the cam bolts; a first annular curing platen for securing spacer members relative to each other; and a second annular curing platen for securing spacer members relative to each other.

Abstract: The disclosed technology includes a pet collar that can be configured to determine its geolocational position and evaluate that position with respect to the geo-fence of a predetermined, geo-fenced “safe” zone. If the collar determines that its position is inside a safe zone but is near the geo-fence, the collar may be configured to provide a warning correction. If the collar determines that it is outside a predetermined safe zone, the collar can also be configured to provide a stronger correction to discourage the pet from continuing away from the safe zone. The collar may also be configured to guide the pet back to the safe zone such as by varying the strength and/or type of correction provided based at least in part on the distance of the collar from the geo-fence.

Abstract: Manual and automated racking systems and associated methods for loading/unloading glass panels (e.g., insulating glass units (IGU), laminated glass units, glass composites. monolithic glass, and the like) onto/from a transportable rack, and a rack for use with the manual and automated racking systems.

Abstract: According to examples, a test instrument may determine equalization setting values for electrical signals communicated with optical modules. Particularly, the test instrument may automatically determine the equalization setting values that may result in an optimal signal quality metric of electrical signals communicated with an optical module. The test instrument may generate test signals having a plurality of equalization setting value permutations applied to the test signals and may determine respective signal quality metrics of the test signals returned from the optical module. In other examples, the optical module may generate the test signals and the optical module or the test instrument may determine the respective signal quality metrics of the test signals. In either of these examples, the values of the equalization settings may be set to be applied on electrical signals communicated with the optical module to improve a quality of the electrical signal communications with the optical module.

Abstract: Example implementations relate to a pressure regulator assembly for a closed fluid loop of a CDU. The pressure regulator assembly has a cylinder having an internal volume, and first and second hollow pistons slidably connected to the cylinder to split the internal volume into a first volume portion having cooling fluid, a second volume portion having driver fluid, and a third volume portion having compressible matter. The first volume portion is fluidically connected to the closed fluid loop. The first hollow piston is reciprocated by the compressible matter to maintain operating pressure of the cooling fluid in the closed fluid loop. The second hollow piston is driven by the driver fluid in response to predefined pressure drop of the cooling fluid during predefined time period, to inject additional cooling fluid from the first volume portion into the closed fluid loop to restore pressure level of cooling fluid to operating pressure.

Abstract: Distributed firewalls reside at different points across a network. Each distributed firewall can include one or more rules that govern traffic over and/or access to the network. The rules can be discovered, converted into a standardized format, and indexed at a centralized rule database. The rules or data of the rules can be verified. The rules can be certified at the centralized database. The certification process can be based on a direction of traffic to which the rule governs. The certification process may have different levels based on the direction of traffic.

Abstract: Systems and methods for multiple device consumption of shared namespaces of ephemeral storage devices by a consumer of a virtual storage system are provided. In an example, multiple namespaces of respective ephemeral storage devices are shared among multiple of consumers of a virtual storage system by creating multiple partitions within each of the namespaces for use by respective consumers of the multiple consumers. Corresponding partitions of respective shared namespace may then be treated as a stripe set to facilitate multiple device consumption for a subsystem (e.g., operation log journaling) of the virtual storage system by striping data associated with input/output (I/O) requests of a consumer (e.g., a journaling driver) across one or more stripe units of one or more stripes within the stripe set.

Abstract: Compositions, formulations and methods of use thereof for treating, preventing and improving the condition and aesthetic appearance of skin are described. Compositions, formulations and methods of use thereof for treatment of dermis wounds, aged dermis, diseased dermis or damaged dermis are also described. The present compositions and formulations comprise a peptide with an amino acid sequence of QHREDGS (SEQ ID NO: 1) and methods of use thereof.

Abstract: In one embodiment, a device obtains one or more packets of a traffic session in a network. The device determines, for a particular packet of the one or more packets that match a filter, a fingerprint for the particular packet. The device identifies a plurality of traffic sessions whose packets match the fingerprint, wherein each of the plurality of traffic sessions is associated with at least one process. The device updates a process with the traffic session by applying a classifier to the plurality of traffic sessions.

Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.

Abstract: A masking tool system includes a first masking body and a second masking body. The first masking body includes a bore passing through a portion of the first masking body and a first sealing element disposed on a first end of the first masking body. The second masking body includes a bore passing through the second masking body and a second sealing element disposed on a first end of the second masking body. The system may also include a rod configured to pass through the bores of the first and second masking bodies and to secure the first and second masking bodies to a metallic article placed therebetween. A diagonal length of the masking tool system induces a wobbling rotation during processing.

Abstract: A downhole tool includes a housing configured to be connected between two tubular members. The housing includes a chamber and a plug assembly is disposed in the chamber and divides the chamber into an up-hole portion and a downhole portion. The plug assembly includes a glass member having a predetermined residual surface compression, at least a first face, and at least one strength-reducing surface feature on the first face. The strength-reducing surface feature is configured to cause the glass member to disintegrate when the glass member is exposed to a pressure in the up-hole portion of a magnitude that creates a tensile stress on the first face that exceeds the predetermined residual surface compression.

Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.

Abstract: An aerodynamic golf club head producing reduced aerodynamic drag forces. The club head has crown section attributes and material attributes that impart beneficial aerodynamic properties and performance.