Abstract: Methods, systems and techniques for the accurate measurement breath-borne biomarkers are disclosed. Such methods, systems and techniques may be used for the purposes of detection and/or measurement in breath samples of biomarkers.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away from the printed part, resulting in a part having surface cavities.

Abstract: Systems and methods for distributed key generation is provided. In some embodiments, a public key and a private key are generated using elliptical curve cryptography (ECC) at a group of trusted parties. In some cases, an elliptical curve digital signature algorithm may be employed. Each party also generates a commitment and a blinding factor. The blinding factor may be a randomized polynomial integer. The parties use the commitments from the other parties to validate the public keys before receipt and combining the public keys into a group/aggregate public key. Content encryption keys (CEK) are then encrypted at each of the trusted parties using these aggregate public keys to generate wrapped content encryption keys (WCEK). Private keys are sharded and a sharded private key is generated at each party using the pieces of shards received by the trusted party. Subsequently, criteria may be received that allows for the release of these sharded private keys back to a trusted environment/enclave.

Abstract: A frame apparatus, a kit of parts which includes multiple frames and a connector bracket for connecting the frames together, and a method of interconnecting a plurality of frames and hanging the same from a support surface. The frame apparatus may be a front-loading frame whereby display items are inserted into a display cavity of the frame through an opening in the front surface of the frame through which the display cavity is viewed. The frame may include an outer annular wall that defines the display cavity, an inner annular wall that is spaced apart from the outer annular wall, and a floor that extends between the inner and outer annular walls. The floor may comprise a plurality of apertures to allow for attachment of the frame to various accessories including hanging brackets, connector brackets, trays, and the like.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: An aircraft windscreen comprises a plurality of liquid crystal display (LCD) films positioned on or within various portions of the windscreen to define a corresponding plurality of zones. The opacity of the LCD films are individually and separately controllable by control circuitry in communication with user controls to allow a user to darken or lighten portions of the various LCD films to achieve a desired level of gradient tint in the defined zones to block external light, such as sunlight, from the aircraft.

Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: In one aspect, a mounting assembly for mounting an architectural covering to a support structure may include a bracket configured to be coupled to the support structure and a bracket adapter configured to be coupled to the bracket. In addition, the mounting assembly may include an end mount configured to be coupled to both an adjacent end of the covering and the bracket adapter. In accordance with aspects of the present subject matter, the various components of the mounting assembly may be configured or adapted to provide one or more advantages over known mounting assemblies.

Abstract: A method for operating and maintaining a wind farm comprising a plurality of wind turbines includes determining an odometer for one or more components of at least one of the pluralities of wind turbines in the wind farm, the odometer representing operational usage of the component(s). The method also includes tracking the operational usage for the component(s) using the odometer and a usage threshold. Further, the method includes predicting an expected time frame for one or more preventative maintenance actions based on a comparison of the tracked operational usage and the usage threshold. Moreover, the method includes triggering scheduling of the one or more preventative maintenance actions when the prediction indicates that the tracked operational usage will exceed the usage threshold. In addition, the method includes shutting down the wind turbine or idling the wind turbine once the one or more preventative maintenance actions are scheduled.

Abstract: In a wireless communication system, Distributed Units (DUs) wirelessly receive test data from wireless access points and transfer the test data to a Central Unit (CU). The CU receives the test data from the DUs and estimates data throughputs for combinations of the DUs and the wireless access points based on the test data. The CU selects some of the combinations of the DUs and the wireless access points based on the estimated data throughputs. The CU exchanges user data with the user communication devices and exchanges the user data with the DUs in the selected combinations of the DUs and the wireless access points. The DUs in the selected combinations of the DUs and the wireless access points exchange the user data with the CU and wirelessly exchange the user data with the wireless access points in the selected combinations of the DUs and the wireless access points.

Abstract: A flangeless fluid end comprising a fluid end body releasably attached to a connect plate. The connect plate is attached to a power source using stay rods. The flow bores of the fluid end are sealed without threading a retainer nut into the walls of each bore. Instead, the flow bores are sealed by bolting a retainer to the fluid end body. Plungers to drive fluid through the fluid end body are installed within removable stuffing box sleeves. These sleeves are maintained within the plunger bores by the bolted retainers. A number of features, including the location of seals within bore walls and carbide inserts within valve structures, aid in reducing or transferring wear.

Abstract: Embodiments are directed to systems and techniques to provide smart access control devices with legacy access control systems.

Abstract: Dynamic refresh rate (DRR) switching is used to dynamically update a refresh rate of content presented on an interface. When a first application and a second application are presented on a user interface at a first refresh rate; a request may be received to temporarily boost the first refresh rate to a second, higher, refresh rate. DRR switching is initiated as the first refresh rate is temporarily boosted to a second refresh rate. Applications that are opted in to the second refresh rate receive signals to refresh content at the second refresh rate, while applications that are not opted in to the second refresh rate receive signals to refresh content at a virtualized refresh rate that matches the first refresh rate. Thus, the first application refreshes content at the first refresh rate and the second application refreshes content at the second, higher refresh rate, providing a smooth user experience without unnecessarily utilizing power consumption.

Abstract: Systems and methods for processing geographical zones are provided. The method involves operating at least one processor to: define a bounding box surrounding a geographical zone; iteratively partition the bounding box into a plurality of bounding boxes by, starting with the bounding box in the first iteration: determine whether the bounding box contains more than a predetermined maximum number of vertices; divide the bounding box into two additional bounding boxes if the bounding box contains more than the predetermined maximum number of vertices, repeat the steps of determining and dividing the bounding box for the additional bounding boxes in the next iteration until each additional bounding box does not contain more than the predetermined maximum number of vertices; generate a binary tree data structure representing the geographical zone; search the binary tree data structure to determine whether a vehicle is located within one of the bounding boxes.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Methods for preparing imaging samples by applying a liquid or semiliquid substance to a substrate surface in order to mitigate the deleterious effects of vacuum and other conditions used for sample preparation, thereby preserving the structure of at least a portion of deposited samples. These methods are useful for MS-based electron microscopy (EM) sample preparation at room temperature, but are also applicable to other imaging methods. These methods also enable transmission electron microscopy (TEM) structural confirmation of ions passing through a mass spectrometer. Additionally, only entry-level negative staining techniques for TEM are required, making this technique much more widely available than cryogenic electron microscopy (cryo-EM).

Abstract: A method for reducing a clearance gap between a plurality of rotor blades and a shroud assembly of an engine includes determining, with a flight control system, that an airplane is in a first flight condition. The method also includes adjusting the clearance gap to a first clearance gap distance associated with the first flight condition. Further, the method includes receiving, with the flight control system, a demand for a second flight condition. During the second flight condition, the method includes adjusting at least two independently controllable parameters, the at least two independently controllable parameters comprising, at least, a first parameter for optimizing the clearance gap and a second parameter for satisfying a thrust demand of the engine, the first parameter having a first impact on the clearance gap, the second parameter having a second impact on the clearance gap, the first impact being greater than the second impact.

Abstract: Digital content coediting techniques are described. In an implementation, an edit input specifying an edit to digital content and an action identifier is assigned to the edit. An element identifier of an element of the digital content that is a subject of the edit of the element is obtained along with a previous action identifier identifying a previous edit associated with the element, e.g., as a pair. An edited content region is detected of the digital content corresponding to the edit a candidate edit event is generated including the action identifier, the element identifier, the previous action identifier, and the edited content region.

Abstract: A package of one or more compressed absorbent articles with a tactile indicium is disclosed. The package encloses one or more compressed absorbent articles. The package comprises a plurality of panels forming an outer surface. The outer surface comprises a tactile indicium.

Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.