Abstract: The disclosure describes embodiments of systems, methods, and non-transitory computer readable storage media that enable network transactions between user accounts belonging to different network transaction platforms and unify user account modifications across user accounts on different network transaction platforms. For instance, the disclosed systems can cause two or more network transaction platforms to transmit and/or receive transactional values from one or more intermediary holding accounts upon receiving network transaction requests between user accounts belonging to the two or more network transaction platforms. In addition, the disclosed system can unify user account data on different network transaction platforms by modifying or updating the user account data (e.g., user attributes) by propagating schematized data messages to the one or more other network transaction platforms with instructions to modify or update the user attributes on other user accounts related to the user account.

Abstract: The present disclosure relates to the treatment of agitation caused by noradrenergic hyperarousal in an agitated subject. The present disclosure provides oromucosal dosage forms comprising effective amounts of latrepirdine either alone or in combination with dexmedetomidine or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable carriers and/excipients. Methods of their use are also provided. The present disclosure also provides a method of treating depression by administering oromucosally a therapeutically effective amount of dexmedetomidine alone or in combination with latrepirdine.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.

Abstract: Aspects of the disclosure relate to controlling a vehicle in an autonomous driving mode. For instance, a first location corresponding to a location where the vehicle is to pick up or drop off a passenger is received. A first cost for the vehicle to reach the first location is determined. A second location based on the first location is identified, and a second cost is determined based on a cost for the vehicle to reach the second location and a cost for the passenger to reach the second location. The first cost is compared to the second cost, and a notification is sent based on the notification. In response to sending the notification, instructions to proceed to the second location are received, and in response to receiving the instructions, the vehicle is controlled in the autonomous driving mode to the second location to pick up or drop off the passenger.

Abstract: The disclosure describes embodiments of systems, methods, and non-transitory computer readable storage media that enable network transactions between user accounts belonging to different network transaction platforms and unify user account modifications across user accounts on different network transaction platforms. For instance, the disclosed systems can cause two or more network transaction platforms to transmit and/or receive transactional values from one or more intermediary holding accounts upon receiving network transaction requests between user accounts belonging to the two or more network transaction platforms. In addition, the disclosed system can unify user account data on different network transaction platforms by modifying or updating the user account data (e.g., user attributes) by propagating schematized data messages to the one or more other network transaction platforms with instructions to modify or update the user attributes on other user accounts related to the user account.

Abstract: Systems and methods are provided for indexing a layup mandrel. One embodiment is a method for indexing a layup mandrel for a composite part. The method includes identifying a surface of a layup mandrel that travels in a process direction during fabrication of a composite part, placing a lamination head in contact with the surface, traversing the surface of the layup mandrel with the lamination head, acquiring a stream of 3D coordinates of the lamination head as the lamination head traverses the surface, characterizing the layup mandrel based on the stream of 3D coordinates, altering a Numerical Control (NC) program that directs layup of fiber reinforced material at the layup mandrel, based on a difference between the alignment of the layup mandrel and a nominal alignment of the layup mandrel.

Abstract: A method includes: hosting, by a computing device, a videoconference among plural users; receiving, by the computing device, input from a sharing user of the plural users, wherein the input initiates a screenshare in the videoconference; creating, by the computing device, document twins of a document shown in the screenshare; and providing, by the computing device and to other users of the plural users, access to respective ones of the document twins in an interface of the videoconference; wherein each of the other users may scroll within a respective one of the document twins independently of other ones of the other users and independently of the screenshare.

Abstract: A computer-implemented method includes: receiving, by a computing device, text extracted from a webpage in a browser and a Uniform Resource Locator (URL) of a linked webpage associated with the text; generating, by the computing device, questions based on the text; retrieving, by the computing device, content of the linked webpage using the URL; generating, by the computing device, answers to the questions using the retrieved content; and returning, by the computing device, the questions and the answers to the browser such that the browser displays the questions and the answers in the webpage.

Abstract: Embodiments of the present invention provide computer-implemented methods, computer program products and computer systems. Embodiments of the present invention can, in response to receiving a request, identify a core component from source material based on topic analysis. Embodiments of the present invention can then generate three-dimensional representations of physical core components associated with the request. Finally, embodiments of the present invention then render the generated three-dimensional representations of the physical core components over the physical core components.

Abstract: A computer-implemented method including: displaying, by a mobile device, a push notification from an application of the mobile device; determining, by the mobile device, an associated notification parameter for the push notification; receiving, by the mobile device, a user input by a user of the mobile device; determining, by the mobile device, the user input indicates interest in the push notification; and maintaining, by the mobile device, presence of the push notification on a display of the mobile device based on determining the user input indicates interest in the push notification and the associated notification parameter.

Abstract: A method includes: hosting, by a computing device, a videoconference among plural users; receiving, by the computing device, input from a sharing user of the plural users, wherein the input initiates a screenshare in the videoconference; creating, by the computing device, document twins of a document shown in the screenshare; and providing, by the computing device and to other users of the plural users, access to respective ones of the document twins in an interface of the videoconference; wherein each of the other users may scroll within a respective one of the document twins independently of other ones of the other users and independently of the screenshare.

Abstract: A computer-implemented method includes: receiving, by a computing device, text extracted from a webpage in a browser and a Uniform Resource Locator (URL) of a linked webpage associated with the text; generating, by the computing device, questions based on the text; retrieving, by the computing device, content of the linked webpage using the URL; generating, by the computing device, answers to the questions using the retrieved content; and returning, by the computing device, the questions and the answers to the browser such that the browser displays the questions and the answers in the webpage.

Abstract: A machine learning model repeatedly scans data exhaust for workstations (for which there are retention requirements regarding data exhaust) over a period of time. The machine learning model analyzes the respective data exhaust and the retention requirements to determine respective data exhaust logging parameters for each workstation. The machine learning model monitors respective data exhaust activity for each workstation over a subsequent period of time. An instance is identified in which logging activity of data exhaust for an identified workstation fails the retention requirements. An ameliorative action designed to satisfy the respective retention requirements for the identified workstation is executed.

Abstract: A computer-implemented method for re-notifying a user about a previous notification is disclosed. The computer-implemented method includes determining a baseline notification rate of the user. The computer-implemented method further includes determining whether the user's current notification rate exceeds a predetermined threshold with respect to the baseline notification rate. The computer-implemented method further includes determining, in response to the user's current notification rate exceeding the predetermined threshold, whether renotification of a notification is required. The computer-implemented method further includes re-notifying, in response to determining that renotification of the notification is required, the user about the notification.

Abstract: A machine learning model repeatedly scans data exhaust for workstations (for which there are retention requirements regarding data exhaust) over a period of time. The machine learning model analyzes the respective data exhaust and the retention requirements to determine respective data exhaust logging parameters for each workstation. The machine learning model monitors respective data exhaust activity for each workstation over a subsequent period of time. An instance is identified in which logging activity of data exhaust for an identified workstation fails the retention requirements. An ameliorative action designed to satisfy the respective retention requirements for the identified workstation is executed.

Abstract: Embodiments of the present invention provide computer-implemented methods, computer program products and computer systems. Embodiments of the present invention can, in response to receiving a request, identify a core component from source material based on topic analysis. Embodiments of the present invention can then generate three-dimensional representations of physical core components associated with the request. Finally, embodiments of the present invention then render the generated three-dimensional representations of the physical core components over the physical core components.

Abstract: A computer-implemented method for re-notifying a user about a previous notification is disclosed. The computer-implemented method includes determining a baseline notification rate of the user. The computer-implemented method further includes determining whether the user's current notification rate exceeds a predetermined threshold with respect to the baseline notification rate. The computer-implemented method further includes determining, in response to the user's current notification rate exceeding the predetermined threshold, whether renotification of a notification is required. The computer-implemented method further includes re-notifying, in response to determining that renotification of the notification is required, the user about the notification.

Abstract: A method for providing active fall prevention assistance to a user. The method includes one or more computer processors mapping a work area where a user performs a plan of tasks. The method further includes determining a safety configuration related to the user and the task. The method further includes instructing an autonomous device to attach a first tether between a first anchor point and a safety harness secured to the user. The method further includes analyzing real-time images of the work area and the user while the user performs the task. The method further includes determining that the user is at risk of falling. The method further includes responding to determining that the user is at risk of falling by instructing the autonomous device to attach a second tether between a second anchor point and the safety harness secured to the user.

Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.

Abstract: Apparatuses and methods for producing, capturing, portioning, and/or distributing smoke or vapor in a manner analogous to liquid consumption that may allow for social and/or more socially acceptable manners of consumption of vapor products. Further, the present disclosure may provide devices and techniques that readily and easily permit transportation, storage, and/or consumption in more socially acceptable and/or less stigmatized manners similar to liquid consumption.