Patents by Inventor Michael Sha

Michael Sha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200263227
    Abstract: A method of transferring material from a first microfabricated device to a second microfabricated device. At least one magnetic bead is loaded into at least one microwell of the first microfabricated device, where a plurality of cells are cultivated. The second microfabricated device is positioned such that the at least one microwell of the first array of microwells is aligned with at least one microwell of the second array of microwells. A magnetic field is applied so as to move the at least one magnetic bead contained in the at least one microwell of the first microfabricated device into the at least one microwell of the second microfabricated device. In this manner, at least one cell from the plurality of cells in the at least one microwell of the first microfabricated device is transferred to the at least one microwell of the second microfabricated device.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 20, 2020
    Inventors: Alexander Hallock, Michael Sha
  • Patent number: 10590461
    Abstract: A method of transferring material from a first microfabricated device to a second microfabricated device. At least one magnetic bead is loaded into at least one microwell of the first microfabricated device, where a plurality of cells are cultivated. The second microfabricated device is positioned such that the at least one microwell of the first array of microwells is aligned with at least one microwell of the second array of microwells. A magnetic field is applied so as to move the at least one magnetic bead contained in the at least one microwell of the first microfabricated device into the at least one microwell of the second microfabricated device. In this manner, at least one cell from the plurality of cells in the at least one microwell of the first microfabricated device is transferred to the at least one microwell of the second microfabricated device.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: March 17, 2020
    Assignee: GENERAL AUTOMATION LAB TECHNOLOGIES INC.
    Inventors: Alexander Hallock, Michael Sha
  • Publication number: 20180023112
    Abstract: A method of transferring material from a first microfabricated device to a second microfabricated device. At least one magnetic bead is loaded into at least one microwell of the first microfabricated device, where a plurality of cells are cultivated. The second microfabricated device is positioned such that the at least one microwell of the first array of microwells is aligned with at least one microwell of the second array of microwells. A magnetic field is applied so as to move the at least one magnetic bead contained in the at least one microwell of the first microfabricated device into the at least one microwell of the second microfabricated device. In this manner, at least one cell from the plurality of cells in the at least one microwell of the first microfabricated device is transferred to the at least one microwell of the second microfabricated device.
    Type: Application
    Filed: June 27, 2017
    Publication date: January 25, 2018
    Inventors: Alexander Hallock, Michael Sha
  • Patent number: 9129720
    Abstract: This invention provides non-spherical nanoparticle compositions that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: September 8, 2015
    Assignee: William Marsh Rice University
    Inventors: Subashini Asokan, Michael Sha-nang Wong
  • Publication number: 20130337569
    Abstract: Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
    Type: Application
    Filed: October 23, 2012
    Publication date: December 19, 2013
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventors: Michael J. Natan, Sharron Gaynor Penn, Remy Cromer, Michael Sha
  • Patent number: 8605280
    Abstract: The invention relates to a multimetallic nanoshell sensor which comprises a core that is less conductive that a first metallic layer and having a catalytically active second metallic layer partially or completely surrounding the first metallic layer. The sensor can be used in any surface enhanced spectroscopic applications.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: December 10, 2013
    Assignee: William Marsh Rice University
    Inventors: Kimberly Nadia Heck, Nancy Jean Halas, Michael Sha-Nang Wong
  • Patent number: 8455392
    Abstract: A new type of solid acid catalyst, which promises better catalytic performance than conventionally prepared supported metal oxides due to its precisely synthesized nanostructure has been described. The catalyst is nanoparticulate in form and is comprised of monolayers of tungstated zirconia of the formula, WOxZryO4-2y made by impregnating a support with zirconium and tungsten. The support catalyst is further characterized in having a tugsten monolayer between greater than 0001 W/nm2 to about 30 W/nm2.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: June 4, 2013
    Assignees: William Marsh Rice University, Lehigh University
    Inventors: Israel E. Wachs, Elizabeth I. Ross-Medgaarden, Michael Sha-nang Wong
  • Publication number: 20130040143
    Abstract: This invention provides non-spherical nanoparticle compositions that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.
    Type: Application
    Filed: October 17, 2012
    Publication date: February 14, 2013
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Subashini ASOKAN, Michael Sha-nang WONG
  • Patent number: 8337809
    Abstract: Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: December 25, 2012
    Assignee: William Marsh Rice University
    Inventors: Jie Yu, Michael Sha-nang Wong, Bahman Anvari, Mohammad Abbas Yaseen
  • Patent number: 8313714
    Abstract: Embodiments of the invention provide a method of making non-spherical nanoparticles that includes (a) combining a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; and (b) isolating non-spherical nanoparticles from the resulting reaction mixture. Other embodiments of the invention provide non-spherical nanoparticle compositions, that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: November 20, 2012
    Assignee: William Marsh Rice University
    Inventors: Subashini Asokan, Michael Sha-nang Wong
  • Publication number: 20120164624
    Abstract: Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.
    Type: Application
    Filed: August 1, 2008
    Publication date: June 28, 2012
    Applicant: OXONICA, INC.
    Inventors: Michael J. Natan, Sharron Gaynor Penn, Remy Cromer, Michael Sha
  • Publication number: 20110090497
    Abstract: The invention relates to a multimetallic nanoshell sensor which comprises a core that is less conductive that a first metallic layer and having a catalytically active second metallic layer partially or completely surrounding the first metallic layer. The sensor can be used in any surface enhanced spectroscopic applications.
    Type: Application
    Filed: November 6, 2008
    Publication date: April 21, 2011
    Applicant: Rice University
    Inventors: Kimberly Nadia Heck, Nancy Jean Halas, Michael Sha-Nang Wong
  • Publication number: 20110059842
    Abstract: A new type of solid acid catalyst, which promises better catalytic performance than conventionally prepared supported metal oxides due to its precisely synthesized nanostructure has been described. The catalyst is nanoparticulate in form and is comprised of monolayers of tungstated zirconia of the formula, WOxZryO4-2y made by impregnating a support with zirconium and tungsten. The support catalyst is further characterized in having a tugsten monolayer between greater than 0001 W/nm2 to about 30 W/nm2.
    Type: Application
    Filed: June 20, 2008
    Publication date: March 10, 2011
    Applicants: RICE UNIVERSITY, LEHIGH UNIVERSITY
    Inventors: Israel E. Wachs, Elizabeth I. Ross-Medgaarden, Michael Sha-nang Wong
  • Publication number: 20100047356
    Abstract: Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.
    Type: Application
    Filed: September 11, 2007
    Publication date: February 25, 2010
    Applicant: William Marsh Rice University
    Inventors: Jie Yu, Michael Sha-nang Wong, Bahman Anvari, Mohammad Abbas Yaseen
  • Publication number: 20100025637
    Abstract: Embodiments of the invention provide a method of making non-spherical nanoparticles that includes (a) combining a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; and (b) isolating non-spherical nanoparticles from the resulting reaction mixture. Other embodiments of the invention provide non-spherical nanoparticle compositions, that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.
    Type: Application
    Filed: April 11, 2008
    Publication date: February 4, 2010
    Applicant: Rice University
    Inventors: Subashini Asokan, Michael Sha-nang Wong
  • Publication number: 20090298197
    Abstract: An assay and method of assay for optical detection of bioagents, a target nucleic acid or a target protein using a surface enhanced Raman scattering (SERS) active biomolecule molecular beacon. The present invention also provides the assay and method in a multiplexed format.
    Type: Application
    Filed: November 15, 2006
    Publication date: December 3, 2009
    Applicant: OXONICA MATERIALS INC.
    Inventors: Michael J. Natan, Michael Sha, William E. Doering
  • Patent number: 7590564
    Abstract: Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: September 15, 2009
    Assignee: Amazon Technologies, Inc.
    Inventors: Charles L. Ward, Vijay Ravindran, David I. Gellman, Jeffrey A. Holden, Nanyan Nicholls, Michael Sha, Jeffrey P. Bezos
  • Patent number: 7590565
    Abstract: Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: September 15, 2009
    Assignee: Amazon Technologies, Inc.
    Inventors: Charles L. Ward, Vijay Ravindran, David I. Gellman, Jeffrey A. Holden, Nanyan Nicholls, Michael Sha, Jeffrey P. Bezos
  • Publication number: 20060173749
    Abstract: Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.
    Type: Application
    Filed: June 30, 2005
    Publication date: August 3, 2006
    Inventors: Charles Ward, Vijay Ravindran, David Gellman, Jeffrey Holden, Nanyan Nicholls, Michael Sha, Jeffrey Bezos
  • Publication number: 20050048546
    Abstract: Encoded metal nanoparticles conjugated to oligonucleotides, and methods for their use are described.
    Type: Application
    Filed: July 12, 2004
    Publication date: March 3, 2005
    Inventors: Sharron Penn, Michael Sha