Patents by Inventor Michael Sha
Michael Sha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11935152Abstract: A system for identifying biomarkers in a digital image of a Hematoxylin and Eosin-stained slide of a target tissue includes a processor and an electronic network; and a memory having stored thereon computer-executable instructions that, when executed by the one or more processors, cause the computing system to: process segmented tile images determine a predicted biomarker presence; and transmit the predicted presence. A non-transitory computer-readable medium includes a set of computer-executable instructions that, when executed by one or more processors, cause a computer to: process segmented tile images; determine a predicted biomarker presence; and transmit the predicted presence. A computer-implemented method includes processing segmented tile images; determining a predicted biomarker presence; and transmitting the predicted presence.Type: GrantFiled: March 20, 2023Date of Patent: March 19, 2024Assignee: TEMPUS LABS, INC.Inventors: Stephen Yip, Irvin Ho, Lingdao Sha, Boleslaw Osinski, Aly Azeem Khan, Andrew J. Kruger, Michael Carlson, Abel Greenwald, Caleb Willis
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Publication number: 20240083910Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.Type: ApplicationFiled: December 14, 2021Publication date: March 14, 2024Applicant: Merck Sharp & Dohme LLCInventors: Richard Thaddeus Berger, JR., Christopher Douglas Cox, Brendan M. Crowley, Marc Labroli, Michael Aaron Plotkin, Izzat Tiedje Raheem, Deyou Sha, Anthony W. Shaw, Jason W. Skudlarek, Ling Tong
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Publication number: 20200263227Abstract: A method of transferring material from a first microfabricated device to a second microfabricated device. At least one magnetic bead is loaded into at least one microwell of the first microfabricated device, where a plurality of cells are cultivated. The second microfabricated device is positioned such that the at least one microwell of the first array of microwells is aligned with at least one microwell of the second array of microwells. A magnetic field is applied so as to move the at least one magnetic bead contained in the at least one microwell of the first microfabricated device into the at least one microwell of the second microfabricated device. In this manner, at least one cell from the plurality of cells in the at least one microwell of the first microfabricated device is transferred to the at least one microwell of the second microfabricated device.Type: ApplicationFiled: February 4, 2020Publication date: August 20, 2020Inventors: Alexander Hallock, Michael Sha
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Patent number: 10590461Abstract: A method of transferring material from a first microfabricated device to a second microfabricated device. At least one magnetic bead is loaded into at least one microwell of the first microfabricated device, where a plurality of cells are cultivated. The second microfabricated device is positioned such that the at least one microwell of the first array of microwells is aligned with at least one microwell of the second array of microwells. A magnetic field is applied so as to move the at least one magnetic bead contained in the at least one microwell of the first microfabricated device into the at least one microwell of the second microfabricated device. In this manner, at least one cell from the plurality of cells in the at least one microwell of the first microfabricated device is transferred to the at least one microwell of the second microfabricated device.Type: GrantFiled: June 27, 2017Date of Patent: March 17, 2020Assignee: GENERAL AUTOMATION LAB TECHNOLOGIES INC.Inventors: Alexander Hallock, Michael Sha
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Publication number: 20180023112Abstract: A method of transferring material from a first microfabricated device to a second microfabricated device. At least one magnetic bead is loaded into at least one microwell of the first microfabricated device, where a plurality of cells are cultivated. The second microfabricated device is positioned such that the at least one microwell of the first array of microwells is aligned with at least one microwell of the second array of microwells. A magnetic field is applied so as to move the at least one magnetic bead contained in the at least one microwell of the first microfabricated device into the at least one microwell of the second microfabricated device. In this manner, at least one cell from the plurality of cells in the at least one microwell of the first microfabricated device is transferred to the at least one microwell of the second microfabricated device.Type: ApplicationFiled: June 27, 2017Publication date: January 25, 2018Inventors: Alexander Hallock, Michael Sha
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Patent number: 9129720Abstract: This invention provides non-spherical nanoparticle compositions that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.Type: GrantFiled: October 17, 2012Date of Patent: September 8, 2015Assignee: William Marsh Rice UniversityInventors: Subashini Asokan, Michael Sha-nang Wong
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Publication number: 20130337569Abstract: Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.Type: ApplicationFiled: October 23, 2012Publication date: December 19, 2013Applicant: BECTON, DICKINSON AND COMPANYInventors: Michael J. Natan, Sharron Gaynor Penn, Remy Cromer, Michael Sha
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Patent number: 8605280Abstract: The invention relates to a multimetallic nanoshell sensor which comprises a core that is less conductive that a first metallic layer and having a catalytically active second metallic layer partially or completely surrounding the first metallic layer. The sensor can be used in any surface enhanced spectroscopic applications.Type: GrantFiled: November 6, 2008Date of Patent: December 10, 2013Assignee: William Marsh Rice UniversityInventors: Kimberly Nadia Heck, Nancy Jean Halas, Michael Sha-Nang Wong
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Patent number: 8455392Abstract: A new type of solid acid catalyst, which promises better catalytic performance than conventionally prepared supported metal oxides due to its precisely synthesized nanostructure has been described. The catalyst is nanoparticulate in form and is comprised of monolayers of tungstated zirconia of the formula, WOxZryO4-2y made by impregnating a support with zirconium and tungsten. The support catalyst is further characterized in having a tugsten monolayer between greater than 0001 W/nm2 to about 30 W/nm2.Type: GrantFiled: June 20, 2008Date of Patent: June 4, 2013Assignees: William Marsh Rice University, Lehigh UniversityInventors: Israel E. Wachs, Elizabeth I. Ross-Medgaarden, Michael Sha-nang Wong
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Publication number: 20130040143Abstract: This invention provides non-spherical nanoparticle compositions that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.Type: ApplicationFiled: October 17, 2012Publication date: February 14, 2013Applicant: WILLIAM MARSH RICE UNIVERSITYInventors: Subashini ASOKAN, Michael Sha-nang WONG
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Patent number: 8337809Abstract: Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.Type: GrantFiled: September 11, 2007Date of Patent: December 25, 2012Assignee: William Marsh Rice UniversityInventors: Jie Yu, Michael Sha-nang Wong, Bahman Anvari, Mohammad Abbas Yaseen
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Patent number: 8313714Abstract: Embodiments of the invention provide a method of making non-spherical nanoparticles that includes (a) combining a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; and (b) isolating non-spherical nanoparticles from the resulting reaction mixture. Other embodiments of the invention provide non-spherical nanoparticle compositions, that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.Type: GrantFiled: April 11, 2008Date of Patent: November 20, 2012Assignee: William Marsh Rice UniversityInventors: Subashini Asokan, Michael Sha-nang Wong
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Publication number: 20120164624Abstract: Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful for clinical proteomics. Assay platforms suitable for use within a biological matrix, for example within whole blood or serum are also disclosed. The assay formats described herein may be used to detect any analyte of interest including but not limited to the detection of cells, viruses, bacteria, proteins, DNA, RNA, or small molecules in any type of biological (animal or plant kingdom) or environmental samples including but not limited to whole blood or serum, occult samples, urine, feces, air, drinking water, phage, any organism, multicellular clumps of cells, for example, cancer tissue homogenate.Type: ApplicationFiled: August 1, 2008Publication date: June 28, 2012Applicant: OXONICA, INC.Inventors: Michael J. Natan, Sharron Gaynor Penn, Remy Cromer, Michael Sha
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Publication number: 20110090497Abstract: The invention relates to a multimetallic nanoshell sensor which comprises a core that is less conductive that a first metallic layer and having a catalytically active second metallic layer partially or completely surrounding the first metallic layer. The sensor can be used in any surface enhanced spectroscopic applications.Type: ApplicationFiled: November 6, 2008Publication date: April 21, 2011Applicant: Rice UniversityInventors: Kimberly Nadia Heck, Nancy Jean Halas, Michael Sha-Nang Wong
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Publication number: 20110059842Abstract: A new type of solid acid catalyst, which promises better catalytic performance than conventionally prepared supported metal oxides due to its precisely synthesized nanostructure has been described. The catalyst is nanoparticulate in form and is comprised of monolayers of tungstated zirconia of the formula, WOxZryO4-2y made by impregnating a support with zirconium and tungsten. The support catalyst is further characterized in having a tugsten monolayer between greater than 0001 W/nm2 to about 30 W/nm2.Type: ApplicationFiled: June 20, 2008Publication date: March 10, 2011Applicants: RICE UNIVERSITY, LEHIGH UNIVERSITYInventors: Israel E. Wachs, Elizabeth I. Ross-Medgaarden, Michael Sha-nang Wong
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Publication number: 20100047356Abstract: Novel phototherapeutic methods and compositions are described herein. Nanoparticle-assembled microcapsules as a new type of delivery vehicle for photosensitive compounds may be synthesized through a two-step assembly process. Charged polymer chains and counterions may be combined with a photosensitive compound to form photosensitive aggregates, and then nanoparticles may be combined with the aggregates to form the microcapsules. The shell may be composed of nanoparticles and/or polymer, and the core interior may contain the photosensitive compound. Formation occurs rapidly (on the order of seconds) and the conditions are very mild (at room temperature, in aqueous solution, and at neutral pH). The microcapsule synthesis is highly suitable as an encapsulation method, particularly for a charged photosensitive molecule like ICG.Type: ApplicationFiled: September 11, 2007Publication date: February 25, 2010Applicant: William Marsh Rice UniversityInventors: Jie Yu, Michael Sha-nang Wong, Bahman Anvari, Mohammad Abbas Yaseen
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Publication number: 20100025637Abstract: Embodiments of the invention provide a method of making non-spherical nanoparticles that includes (a) combining a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; and (b) isolating non-spherical nanoparticles from the resulting reaction mixture. Other embodiments of the invention provide non-spherical nanoparticle compositions, that are the reaction product of a source of a Group 12, 13, 14, or 15 metal or metalloid; a source of a Group 15 or 16 element; and a source of a quaternary ammonium compound or phosphonium compound; wherein nanoparticle tetrapods comprise 75-100 number percent of the nanoparticle products.Type: ApplicationFiled: April 11, 2008Publication date: February 4, 2010Applicant: Rice UniversityInventors: Subashini Asokan, Michael Sha-nang Wong
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Publication number: 20090298197Abstract: An assay and method of assay for optical detection of bioagents, a target nucleic acid or a target protein using a surface enhanced Raman scattering (SERS) active biomolecule molecular beacon. The present invention also provides the assay and method in a multiplexed format.Type: ApplicationFiled: November 15, 2006Publication date: December 3, 2009Applicant: OXONICA MATERIALS INC.Inventors: Michael J. Natan, Michael Sha, William E. Doering
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Patent number: 7590565Abstract: Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.Type: GrantFiled: June 30, 2005Date of Patent: September 15, 2009Assignee: Amazon Technologies, Inc.Inventors: Charles L. Ward, Vijay Ravindran, David I. Gellman, Jeffrey A. Holden, Nanyan Nicholls, Michael Sha, Jeffrey P. Bezos
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Patent number: 7590564Abstract: Computer-accessible medium and apparatus for providing subscription-based shipping of items. Embodiments may provide mechanisms that allow customers of an e-commerce Web site to pay a fee to obtain a subscription in a shipping program that provides subscribed customers with free and/or reduced-rate shipping for at least some items ordered via the e-commerce Web site during the period covered by the subscription. The Web site may provide user interface elements on the Web site that may provide one or more shipping and possibly other options only to subscribed customers. Some embodiments may provide mechanisms that allow a subscriber to share a subscription to the shipping program with other customers. One embodiment may provide a mechanism through which a subscribed customer can invite other customers to share a subscription. Some embodiments may provide other exclusive services and/or offers to the subscribers of the shipping program that are not provided or offered to non-subscribers.Type: GrantFiled: June 30, 2005Date of Patent: September 15, 2009Assignee: Amazon Technologies, Inc.Inventors: Charles L. Ward, Vijay Ravindran, David I. Gellman, Jeffrey A. Holden, Nanyan Nicholls, Michael Sha, Jeffrey P. Bezos